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3,068 results
  • Pharmacogenomics in chronic pain therapy: from disease to treatment and challenges for clinical practice. [Journal Article]
    Pharmacogenomics 2019; 20(13):971-982Yamamoto PA, Conchon Costa AC, … de Moraes NV
  • Pharmacogenomics (PGx) has emerged as an encouraging tool in chronic pain therapy. Genetic variations associated with drug effectiveness or adverse reactions (amitriptyline/nortriptyline/codeine/oxycodone/tramadol-CYP2D6, amitriptyline-CYP2C19, carbamazepine-HLA-A, carbamazepine/oxcarbazepine-HLA-B) can be used to guide chronic pain management. Despite this evidence, many obstacles still need to …
  • Interventions to increase adherence to medications for tobacco dependence. [Journal Article]
    Cochrane Database Syst Rev 2019; 8:CD009164Hollands GJ, Naughton F, … Aveyard P
  • CONCLUSIONS: In people who are stopping smoking and receiving behavioural support, there is moderate-certainty evidence that enhanced behavioural support focusing on adherence to smoking cessation medications can modestly improve adherence. There is only low-certainty evidence that this may slightly improve the likelihood of cessation in the shorter or longer-term. Interventions to increase adherence can aim to address the practicalities of taking medication, change perceptions about medication, such as reasons to take it or concerns about doing so, or both. However, there is currently insufficient evidence to confirm which approach is more effective. There is no evidence on whether such interventions are effective for people who are stopping smoking without standard behavioural support.
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