- Preschool Age Anthropometric Evaluation of the Nose After Bilateral Complete Cleft Lip Repair. [Journal Article]
- JCJ Craniofac Surg 2019; 30(5):1475-1478
- CONCLUSIONS: This treatment protocol for bilateral cleft lip was able to achieve most of the aesthetic goals in terms of NTH, CH, DH, ratio of CH to NW, and ratio of DH to CH. However, more surgical correction of NW and CLAs may be needed.
- Elucidating pyrolysis behaviour of activated sludge in granular and flocculent form: Reaction kinetics and mechanism. [Journal Article]
- WRWater Res 2019 Jul 01; 162:409-419
- The pyrolysis kinetics of sewage sludge was studied to determine the constituent of sludge and explore the feasibility of pyrolytic post-treatment. Both flocculent sludge and granular sludge were pyr…
The pyrolysis kinetics of sewage sludge was studied to determine the constituent of sludge and explore the feasibility of pyrolytic post-treatment. Both flocculent sludge and granular sludge were pyrolysed in a thermogravimetric analyser under inert atmospheric conditions. The pyrolysis of granular sludge and flocculent sludge were described by three parallel reactions model with three individual pseudo-components. The decomposition activation energy values of the three pseudo-components were determined by iso-conversional methods to be 263.97 kJ/mol, 257.18 kJ/mol and 153.61 kJ/mol in flocculent sludge and 139.89 kJ/mol, 228.78 kJ/mol and 142.78 kJ/mol in granular sludge, respectively. Granular sludge exhibited better thermal stability but lower devolatilisation activation energy than flocculent sludge, which could be attributed by enriched alkali and alkaline metals during granulation. Master plots of experimental data sets suggested that the decomposition of all organic pseudo-components of flocculent sludge followed the nth-order mechanism while the pyrolytic mechanism of the first organic fraction in granular sludge coincided with random nucleation and nuclei growth. By investigating the pyrolytic behaviour, this study sheds light on the composition of granular sludge and the impact of sludge components on granular sludge pyrolysis, and lays the foundation for the treatment of waste granular sludge with potential for resource and energy recovery in the near future.
- Effective non-adiabatic Hamiltonians for the quantum nuclear motion over coupled electronic states. [Journal Article]
- JCJ Chem Phys 2019 Jul 07; 151(1):014113
- The quantum mechanical motion of the atomic nuclei is considered over a single- or a multidimensional subspace of electronic states which is separated by a gap from the rest of the electronic spectru…
The quantum mechanical motion of the atomic nuclei is considered over a single- or a multidimensional subspace of electronic states which is separated by a gap from the rest of the electronic spectrum over the relevant range of nuclear configurations. The electron-nucleus Hamiltonian is block-diagonalized up to O(εn+1) through a unitary transformation of the electronic subspace, and the corresponding nth-order effective Hamiltonian is derived for the quantum nuclear motion. Explicit but general formulas are given for the second- and the third-order corrections. As a special case, the second-order Hamiltonian corresponding to an isolated electronic state is recovered which contains the coordinate-dependent mass-correction terms in the nuclear kinetic energy operator. For a multidimensional, explicitly coupled electronic band, the second-order Hamiltonian contains the usual Born-Oppenheimer terms and nonadiabatic corrections, but generalized mass-correction terms appear as well. These, earlier neglected terms, perturbatively account for the outlying (discrete and continuous) electronic states not included in the explicitly coupled electronic subspace.
- Reverse and toroidal flux of light fields with both phase and polarization higher-order singularities in the sharp focus area. [Journal Article]
- OEOpt Express 2019 Jun 10; 27(12):16689-16702
- Based on the Richards-Wolf formalism, we obtain for the first time a set of explicit analytical expressions that completely describe a light field with a double higher-order singularity (phase and po…
Based on the Richards-Wolf formalism, we obtain for the first time a set of explicit analytical expressions that completely describe a light field with a double higher-order singularity (phase and polarization), as well as distributions of its intensity and energy flux near the focus. A light field with the double singularity is an optical vortex with a topological charge m and with nth-order cylindrical polarization (azimuthal or radial). From the theory developed, rather general predictions follow. 1) For any singularity orders m and n, the intensity distribution near the focus has a symmetry of order 2(n - 1), while the longitudinal component of the Poynting vector has always an axially symmetric distribution. 2) If n = m + 2, there is a reverse energy flux on the optical axis near the focus, which is comparable in magnitude with the forward flux. 3) If m ≠0, forward and reverse energy fluxes rotate along a spiral around the optical axis, whereas at m = 0 the energy flux is irrotational. 4) For any values of m and n, there is a toroidal energy flux in the focal area near the dark rings in the distribution of the longitudinal component of the Poynting vector.
- High-dimensional geometry of population responses in visual cortex. [Journal Article]
- NatNature 2019; 571(7765):361-365
- A neuronal population encodes information most efficiently when its stimulus responses are high-dimensional and uncorrelated, and most robustly when they are lower-dimensional and correlated. Here we…
A neuronal population encodes information most efficiently when its stimulus responses are high-dimensional and uncorrelated, and most robustly when they are lower-dimensional and correlated. Here we analysed the dimensionality of the encoding of natural images by large populations of neurons in the visual cortex of awake mice. The evoked population activity was high-dimensional, and correlations obeyed an unexpected power law: the nth principal component variance scaled as 1/n. This scaling was not inherited from the power law spectrum of natural images, because it persisted after stimulus whitening. We proved mathematically that if the variance spectrum was to decay more slowly then the population code could not be smooth, allowing small changes in input to dominate population activity. The theory also predicts larger power-law exponents for lower-dimensional stimulus ensembles, which we validated experimentally. These results suggest that coding smoothness may represent a fundamental constraint that determines correlations in neural population codes.
- Hemoperitoneum in cirrhotic patients in the absence of abdominal trauma. [Journal Article]
- ERExpert Rev Gastroenterol Hepatol 2019 Jun 17; :1-10
- Introduction: Hemoperitoneum can be a life-threating condition in cirrhotic patients who have a limited compensatory reserve during hemorrhagic shock. We aim to review the literature on the different…
Introduction: Hemoperitoneum can be a life-threating condition in cirrhotic patients who have a limited compensatory reserve during hemorrhagic shock. We aim to review the literature on the different etiologies associated with non-traumatic hemoperitoneum (NTH), summarizing the most relevant conditions associated with spontaneous and iatrogenic peritoneal and retroperitoneal bleeding that may occur in cirrhotic patients and to illustrate the most relevant diagnostic strategies and optimal management. Area covered: This review encompasses the current literature in hemoperitoneum in cirrhotic patients in the absence of abdominal trauma. Established diagnostic procedures, therapeutic interventions and potential novel targets are reported and discussed. Expert opinion: To ensure the optimal management regardless of the underlying etiology of NTH, the first goal for the clinician is to obtain immediate hemodynamic stabilization with supportive measures and to control the source of bleeding. The latter can be achieved with angiographic embolization, which is usually the first choice, or with open surgery. Other therapeutic options according to specific etiologies include transjugular intrahepatic portosystemic shunt (TIPS), balloon-occluded retrograde transvenous obliteration (BRTO), balloon-occluded anterograde transvenous obliteration (BATO) or intra operative radio frequency (RF).
- Basement membrane-like structures containing NTH α1(IV) are formed around the endothelial cell network in a novel in vitro angiogenesis model. [Journal Article]
- AJAm J Physiol Cell Physiol 2019 Jun 12
- Angiogenesis is a process through which new blood vessels are formed by sprouting and elongating from existing blood vessels. Several methods have been used to replicate angiogenesis in vitro, includ…
Angiogenesis is a process through which new blood vessels are formed by sprouting and elongating from existing blood vessels. Several methods have been used to replicate angiogenesis in vitro, including culturing vascular endothelial cells on Matrigel, and co-culturing with endothelial cells and fibroblasts. However, the angiogenesis elongation process has not been completely clarified in these models. We therefore propose a new in vitro model of angiogenesis, suitable for observing vascular elongation, by seeding a spheroid co-cultured from endothelial cells and fibroblasts into a culture dish. In this model, endothelial cells formed tubular networks elongated from the spheroid with a lumen structure and were connected with tight junctions. A basement membrane (BM)-like structure was observed around the tubular network, similarly to blood vessels in vivo. These results suggested that blood vessel-like structure could be reconstituted in our model. Laminin and type IV collagen, main BM components, were highly localized around the network, along with non-triple helical form of type IV collagen α1 chain (NTH α1[IV]). In an ascorbic acid-depleted condition, laminin and NTH α1(IV) were observed around the network but not the triple-helical form of type IV collagen, and the network was unstable. These results suggest that laminin and NTH α1(IV) are involved in the formation of tubular network, and type IV collagen is necessary to stabilize the network.
- Numerical method for nonlinear optical spectroscopies: Ultrafast ultrafast spectroscopy. [Journal Article]
- JCJ Chem Phys 2019 Jun 07; 150(21):214105
- We outline a novel numerical method, called Ultrafast Ultrafast (UF2) spectroscopy, for calculating the nth-order wavepackets required for calculating n-wave mixing signals. The method is simple to i…
We outline a novel numerical method, called Ultrafast Ultrafast (UF2) spectroscopy, for calculating the nth-order wavepackets required for calculating n-wave mixing signals. The method is simple to implement, and we demonstrate that it is computationally more efficient than other methods in a wide range of use cases. The resulting spectra are identical to those calculated using the standard response function formalism but with increased efficiency. The computational speed-ups of UF2 come from (a) nonperturbative and costless propagation of the system time-evolution, (b) numerical propagation only at times when perturbative optical pulses are nonzero, and (c) use of the fast Fourier transform convolution algorithm for efficient numerical propagation. The simplicity of this formalism allows us to write a simple software package that is as easy to use and understand as the Feynman diagrams that organize the understanding of n-wave mixing processes.
- The polyubiquitin gene MrUBI4 is required for conidiation, conidial germination, and stress tolerance in the filamentous fungus Metarhizium robertsii. [Journal Article]
- GGenes (Basel) 2019 May 29; 10(6)
- The polyubiquitin gene is a highly conserved open reading frame that encodes different numbers of tandem ubiquitin repeats from different species, which play important roles in different biological p…
The polyubiquitin gene is a highly conserved open reading frame that encodes different numbers of tandem ubiquitin repeats from different species, which play important roles in different biological processes. Metarhizium robertsii is a fungal entomopathogen that is widely applied in the biological control of pest insects. However, it is unclear whether the polyubiquitin gene is required for fungal development, stress tolerance, and virulence in the entomopathogenic fungus. In the present study, the polyubiquitin gene (MrUBI4, MAA_02160) was functionally characterized via gene deletion in M. robertsii. Compared to the control strains, the MrUBI4 deletion mutant showed delayed conidial germination and significantly decreased conidial yields (39% of the wild-type 14 days post-incubation). Correspondingly, the transcript levels of several genes from the central regulatory pathways associated with conidiation, including brlA, abaA, and wetA, were significantly downregulated, which indicated that MrUBI4 played an important role in asexual sporulation. Deletion of MrUBI4 especially resulted in increased sensitivity to ultraviolet (UV) and heat-shock stress based on conidial germination analysis between mutant and control strains. The significant increase in sensitivity to heat-shock was accompanied with reduced transcript levels of genes related to heat-shock protein (hsp), trehalose, and mannitol accumulation (tps, tpp, nth, and mpd) in the MrUBI4 deletion mutant. Deletion of MrUBI4 has no effect on fungal virulence. Altogether, MrUBI4 is involved in the regulation of conidiation, conidial germination, UV stress, and heat-shock response in M. robertsii.
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- DNA nanotetrahedron linked dual-aptamer based voltammetric aptasensor for cardiac troponin I using a magnetic metal-organic framework as a label. [Journal Article]
- MAMikrochim Acta 2019 May 23; 186(6):374
- An ultrasensitive voltammetric aptasensor was constructed to analyze cardiac troponin I (cTnI). It is based on DNA nanotetrahedron (NTH) linked dual-aptamer (dAPT) and magnetic metal organic framewor…
An ultrasensitive voltammetric aptasensor was constructed to analyze cardiac troponin I (cTnI). It is based on DNA nanotetrahedron (NTH) linked dual-aptamer (dAPT) and magnetic metal organic frameworks (mMOFs) of type Fe3O4@UiO-66. Firstly, the DNA NTH linked dAPT (Tro4 and Tro6) were immobilized on a gold electrode for improving the capture efficiency of cTnI. The novel mMOFs Fe3O4@UiO-66 was then decorated by Au@Pt nanoparticles (Au@PtNPs), horseradish peroxidase (HRP), G-quadruplex/hemin (GQH) DNAzyme, and two types of aptamers to form signaling nanoprobes. In the presence of cTnI, an aptamer-protein-nanoprobe sandwich-type structure is formed. Afterward, the nanoprobes including enzyme, GQH DNAzyme and Fe3O4@UiO-66/Au@PtNP were utilized to catalyze the oxidation of hydroquinone by hydrogen peroxide for the electrochemical signals amplification, typically at a working potential of -0.1 V (vs. Ag/AgCl). The voltammetric signal increases linearly in the 0.01 to 100 ng·mL-1 cTnI concentration range, and the detection limit is 5.7 pg·mL-1. Graphical abstract An ultrasensitive voltammetric aptasensor was constructed to analyze cardiac troponin I (cTnI) based on DNA nanotetrahedron linked dual-aptamer and magnetic metal organic frameworks of type Fe3O4@UiO-66. The results indicated the aptasensor has a wide linear response range (0.01 to 100 ng/mL) and low detection limit (5.74 pg/mL) for cTnI. GE: gold electrode; MCH: 6-Mmercapto-1-hexanol; HRP: horseradish peroxidase; HQ: hydroquinone; BQ: benzoquinone.