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22,020 results
  • Applications of CRISPR/Cas9 Technology in the Treatment of Lung Cancer. [Review]
    Trends Mol Med 2019Jiang C, Lin X, Zhao Z
  • Since its emergence, the application of CRISPR-associated nuclease 9 (Cas9) technology in cancer research has accelerated studies to investigate many aspects of treatment approaches for lung cancer, including the identification of target genes, construction of animal tumor models, and identification of drug resistance-related genes. Moreover, CRISPR/Cas9 can be used in gene therapy for lung cance…
  • Nucleosome positions alone can be used to predict domains in yeast chromosomes. [Journal Article]
    Proc Natl Acad Sci U S A 2019Wiese O, Marenduzzo D, Brackley CA
  • We use molecular dynamics simulations based on publicly available micrococcal nuclease sequencing data for nucleosome positions to predict the 3D structure of chromatin in the yeast genome. Our main aim is to shed light on the mechanism underlying the formation of chromosomal interaction domains, chromosome regions of around 0.5 to 10 kbp which show enriched self-interactions, which were experime…
  • Assessing Oligonucleotide Binding to Double-Stranded DNA. [Journal Article]
    Methods Mol Biol 2019; 2036:91-112Mozafari N, Umek T
  • Sequence-specific targeting of double-stranded DNA (dsDNA) using synthetic oligonucleotides (ONs) has been under investigation in different therapeutic approaches. Several methods can be used to evaluate ONs effect and binding capacity to their target sequence. Here we describe some of the methods, which have been frequently used for assessing ONs binding to dsDNA.
  • Plasmid DNA nicking- a Novel Activity of Soybean Trypsin Inhibitor and Bovine Aprotinin. [Journal Article]
    Sci Rep 2019; 9(1):11596Islam MR, Ihenacho K, … Islam IS
  • Protease inhibitors, such as trypsin inhibitor, serum alpha-1 antitrypsin, or liver aprotinin, are a class of proteins that competitively bind and block the catalytic activity of proteolytic enzymes with wide ranging biological functions. A significant number of protease inhibitors have also been shown to possess antimicrobial activity, presumed to contribute in defense against pathogenic microor…
  • Stochastic RNA Walkers for Intracellular MicroRNA Imaging. [Journal Article]
    Anal Chem 2019Xiao M, Wang X, … Pei H
  • Nucleic acid-based machines have sparked tremendous attention because of their potential applications in biosensing, drug delivery, and biocomputing. Herein, we construct an enzyme-propelled stochastic RNA walker that autonomously walks on a single wall carbon nanotube (SWCNT)-based one-dimensional (1D) track for miRNA imaging in living cells. Driven by duplex-specific nuclease (DSN) with the cap…
  • Valency-Controlled Molecular Spherical Nucleic Acids with Tunable Biosensing Performances. [Journal Article]
    Anal Chem 2019Hu X, Ke G, … Zhang XB
  • Spherical nucleic acids (SNAs) play critical roles in many fields, such as molecular diagnostics, disease therapeutics, and materials application. Due to the important role of DNA density on the properties of SNAs, the controlled synthesis of monodisperse SNAs with precise DNA density is an important approach for the structure-function relationship study and finite functions regulation of SNAs. I…
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