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41 results
  • Detection of Sentinel Lymph Nodes with Near-Infrared Imaging in Malignancies. [Review]
    Mol Imaging Biol 2019; 21(2):219-227Zeng HC, Hu JL, … Zhang GJ
  • Optical molecular imaging, a highly sensitive and noninvasive technique which is simple to operate, inexpensive, and has the real-time capability, is increasingly being used in the diagnosis and treatment of carcinomas. The near-infrared fluorescence dye indocyanine green (ICG) is widely used in optical imaging for the dynamic detection of sentinel lymph nodes (SLNs) in real time improving the de…
  • History, Discovery, and Classification of lncRNAs. [Historical Article]
    Adv Exp Med Biol 2017; 1008:1-46Jarroux J, Morillon A, Pinskaya M
  • The RNA World Hypothesis suggests that prebiotic life revolved around RNA instead of DNA and proteins. Although modern cells have changed significantly in 4 billion years, RNA has maintained its central role in cell biology. Since the discovery of DNA at the end of the nineteenth century, RNA has been extensively studied. Many discoveries such as housekeeping RNAs (rRNA, tRNA, etc.) supported the…
  • [The substance of genetic information--nucleic acids]. [Historical Article]
    Klin Onkol 2012; 25(5):329-32Brdička R
  • If we look at the history of our knowledge of nucleic acids, we would see in the distant past of 140 years Friedrich Miescher who had identified the acidic substance within the cell nucleus, which he called nuclein. About 70 years after his initial observation, this substance was connected with genetic information. This very substantial finding happened during the World War II. This was the impul…
  • [DNA: from Miescher to Venter and beyond]. [Historical Article]
    Postepy Biochem 2009; 55(3):342-54Gabryelska MM, Szymański M, Barciszewski J
  • DNA, one of the most famous molecules is 140-years-old. Its history has engaged three centuries of experiments, leading us to a point, where the Homo sapiens genome sequence is known. The "DNA breakthrough" is dated on 1953, when James Watson and Francis Crick proposed the model of molecular structure of DNA. But the origin of that great achievement goes back to 1869 and early efforts of Friedric…
  • Some major landmarks in the path from nuclein to human genome (1). [Journal Article]
    Toxicol Mech Methods 2006; 16(2-3):137-59Choudhuri S
  • The completion of sequencing of the human genome as well as the genomes of other species is a spectacular achievement of 20th-century biology. It is appropriately regarded as a turning point in biology and medicine for the 21st century. Knowledge of the human genome will presumably help us understand the genetic instructions that make us human. By learning about the gene sequences, the functional…
  • Function and significance of very low density lipoprotein receptor subtype II. [Journal Article]
    J Huazhong Univ Sci Technolog Med Sci 2005; 25(3):229-33Tian J, Bi H, … Qu S
  • To explore the functions of very low density lipoprotein receptor (VLDL-R) subtype II in lipoprotein metabolism and foam cells formation, the recombinant plasmid with the two subtypes cDNA was constructed respectively, the 1dl-A7 cell lines were transfected and two cell lines expressing VLDL-R were obtained: one stably expressing the VLDLR with the O-linked sugar region (type I VLDLR) and the oth…
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