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(nucleocapsid)
20,586 results
  • Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo. [Journal Article]
    JCI Insight 2020Miyagawa K, Ohata Y, … Kurihara N
  • We reported that transgenic mice expressing measles virus nucleocapsid protein (MVNP) in OCLs (MVNP mice) are a Paget's disease (PD) model, and that osteoclasts (OCLs) from PD patients and MVNP mice express high levels of OCL-derived IGF1 (OCL-IGF1). To determine OCL-IGF1's role in PD and normal bone remodeling, we generated WT and MVNP mice with targeted deletion of Igf1 in OCLs (Igf1-cKO) and M…
  • Characterization of a New Orthotospovirus from Chilli Pepper in Yunnan Province, China. [Journal Article]
    Plant Dis 2020; :PDIS09191925REZheng K, Chen TC, … Dong J
  • Chilli pepper (Capsicum annuum L.) is one of the most important crops in Yunnan Province, China. An orthotospovirus isolate 14YV855 was isolated from a diseased chilli pepper plant exhibiting yellow ringspots and necrosis on leaves in Shiping County, Honghe Hani and Yi Autonomous Prefecture, Yunnan Province in 2014. The complete genome sequence of 14YV855 was determined. The small, medium, and la…
  • HIV protease cleaves the antiviral m6A reader protein YTHDF3 in the viral particle. [Journal Article]
    PLoS Pathog 2020; 16(2):e1008305Jurczyszak D, Zhang W, … Simon V
  • N6-methyladenosine (m6A) is the most abundant HIV RNA modification but the interplay between the m6A reader protein YTHDF3 and HIV replication is not well understood. We found that knockout of YTHDF3 in human CD4+ T-cells increases infection supporting the role of YTHDF3 as a restriction factor. Overexpression of the YTHDF3 protein in the producer cells reduces the infectivity of the newly produc…
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