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243 results
  • Protamine withdrawal from human sperm nuclei following heterologous ICSI into hamster oocytes. [Journal Article]
    Protein Pept Lett 2011; 18(8):811-6Jones EL, Zalensky AO, Zalenskaya IA
  • During late stages of spermatogenesis in mammals, most histones bound to DNA are replaced by protamines (PRM), which results in formation of supercondensed and genetically inert sperm chromatin. At fertilization, mature spermatozoon penetrates oocyte and chromatin is remodeled "back" from nucleoprotamine to nucleohistone state. While being crucial for activation of male genome and ultimately for …
  • Spermatozoal RNAs: what about their functions? [Review]
    Microsc Res Tech 2009; 72(8):536-51Dadoune JP
  • The profound architectural changes that transform spermatids into spermatozoa result in a high degree of DNA packaging within the sperm head. However, the mature sperm chromatin that harbors imprinted genes exhibits a dual nucleoprotamine/nucleohistone structure with DNase-sensitive regions, which could be implicated in the establishment of efficient epigenetic information in the developing embry…
  • Sperm chromatin released by nucleases. [Journal Article]
    Syst Biol Reprod Med 2008 Jan-Feb; 54(1):37-46Nazarov IB, Shlyakhtenko LS, … Zalensky AO
  • In human spermatozoa, 15-20% of histones are retained in the nucleus to coexist with protamines. Hypothetically, nucleohistone regions of sperm chromatin mark DNA sequences for distinctive processing during fertilization and early embryogenesis. The structural organization and molecular composition of nucleohistones in human spermatozoa is poorly studied. Here, we isolate and characterize fractio…
  • Relationship between chromatin organization, mRNAs profile and human male gamete quality. [Review]
    Asian J Androl 2007; 9(5):587-92Galeraud-Denis I, Lambard S, Carreau S
  • Spermiogenesis is a complex process leading to the formation of motile spermatozoa characterized by a highly stable chromatin compaction that transfers the paternal genome into the oocyte. It is commonly held that these haploid cells are devoid of transcriptional and translational activities and that the transcripts represent remnants of stored mRNAs. Recently, the chromatin organization of matur…
  • Protamines and male infertility. [Review]
    Hum Reprod Update 2006 Jul-Aug; 12(4):417-35Oliva R
  • Protamines are the major nuclear sperm proteins. The human sperm nucleus contains two types of protamine: protamine 1 (P1) encoded by a single-copy gene and the family of protamine 2 (P2) proteins (P2, P3 and P4), all also encoded by a single gene that is transcribed and translated into a precursor protein. The protamines were discovered more than a century ago, but their function is not yet full…
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