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2,709 results
  • NusG prevents transcriptional invasion of H-NS-silenced genes. [Journal Article]
    PLoS Genet 2019; 15(10):e1008425Bossi L, Ratel M, … Figueroa-Bossi N
  • Evolutionarily conserved NusG protein enhances bacterial RNA polymerase processivity but can also promote transcription termination by binding to, and stimulating the activity of, Rho factor. Rho terminates transcription upon anchoring to cytidine-rich motifs, the so-called Rho utilization sites (Rut) in nascent RNA. Both NusG and Rho have been implicated in the silencing of horizontally-acquired…
  • New protein-DNA complexes in archaea: a small monomeric protein induces a sharp V-turn DNA structure. [Journal Article]
    Sci Rep 2019; 9(1):14253Loth K, Largillière J, … Paquet F
  • MC1, a monomeric nucleoid-associated protein (NAP), is structurally unrelated to other DNA-binding proteins. The protein participates in the genome organization of several Euryarchaea species through an atypical compaction mechanism. It is also involved in DNA transcription and cellular division through unknown mechanisms. We determined the 3D solution structure of a new DNA-protein complex forme…
  • Regulation of cell division in bacteria by monitoring genome integrity and DNA replication status. [Review]
    J Bacteriol 2019Burby PE, Simmons LA
  • All organisms regulate cell cycle progression by coordinating cell division with DNA replication status. In eukaryotes, DNA damage or problems with replication fork progression induce the DNA damage response (DDR) causing cyclin-dependent kinases to remain active preventing further cell cycle progression until replication and repair are complete. In bacteria, cell division is coordinated with chr…
  • Spatial organization of RNA polymerase and its relationship with transcription in Escherichia coli. [Journal Article]
    Proc Natl Acad Sci U S A 2019; 116(40):20115-20123Weng X, Bohrer CH, … Xiao J
  • Recent studies have shown that RNA polymerase (RNAP) is organized into distinct clusters in Escherichia coli and Bacillus subtilis cells. Spatially organized molecular components in prokaryotic systems imply compartmentalization without the use of membranes, which may offer insights into unique functions and regulations. It has been proposed that the formation of RNAP clusters is driven by active…
  • Gene expression in E. coli influences the position and motion of the lac operon and vicinal loci. [Journal Article]
    Biochem Biophys Res Commun 2019; 519(2):438-443Lu YC, Chang YR
  • Transcription and translation of active genes play an important role in determining the global organization of the chromosome. To further elucidate this phenomenon, we examined how the expression of either the lacY or the cfp gene in the native lac operon influences adjacent chromosomal segments by fluorescently labeling loci upstream and downstream of the expressed gene. Based on the positions a…
  • CRISPR-Cas, DNA Supercoiling, and Nucleoid-Associated Proteins. [Review]
    Trends Microbiol 2019Dorman CJ, Ní Bhriain N
  • In this opinion article we highlight links between the H-NS nucleoid-associated protein, variable DNA topology, the regulation of CRISPR-cas locus expression, CRISPR-Cas activity, and the recruitment of novel genetic information by the CRISPR array. We propose that the requirement that the invading mobile genetic element be negatively supercoiled limits effective CRISPR action to a window in the …
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