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17,245 results
  • The Nucleolus and PARP1 in Cancer Biology. [Review]
    Cancers (Basel). 2020 Jul 06; 12(7)Engbrecht M, Mangerich A
  • The nucleolus has been known for a long time to fulfill crucial functions in ribosome biogenesis, of which cancer cells can become addicted to in order to produce sufficient amounts of proteins for cell proliferation. Recently, the nucleolus has emerged as a central regulatory hub in many other cancer-relevant processes, including stress sensing, DNA damage response, cell cycle control, and prote…
  • Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells. [Journal Article]
    EMBO J. 2020 Jul 06 [Online ahead of print]Esgleas M, Falk S, … Götz M
  • TMF1-regulated nuclear protein 1 (Trnp1) has been shown to exert potent roles in neural development affecting neural stem cell self-renewal and brain folding, but its molecular function in the nucleus is still unknown. Here, we show that Trnp1 is a low complexity protein with the capacity to phase separate. Trnp1 interacts with factors located in several nuclear membrane-less organelles, the nucl…
  • NPM1-mutated acute myeloid leukemia: from bench to bedside. [Journal Article]
    Blood. 2020 Jul 01 [Online ahead of print]Falini B, Brunetti L, … Martelli MP
  • The nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent nucleolar localization that shuttles between nucleus and cytoplasm. NPM1 mutations represent the most common genetic lesion in adult AML (about one-third of cases) and act deterministically to cause the aberrant cytoplasmic delocalization of NPM1 mutants. Because of its unique features, NPM1-mutated AML is recogniz…
  • Assessing the effect of interspecies oocyte nucleolar material dosage on embryonic development. [Journal Article]
    Theriogenology. 2020 Jun 09; 155:17-24.Benc M, Martinkova S, … Laurincik J
  • Sequence differences are considered to be the basic cause of developmental failure in interspecies embryos when more distant species are combined. However, other phenomena, such as insufficient or excessive quantity of specific cellular factors, might also influence the outcome. These effects are usually not considered. One of the organelles shown to contain different amount of proteins is the oo…
  • Leukocyte Nucleolus and Anisakis pegreffii-When Falling Apart Means Falling in Place. [Journal Article]
    Genes (Basel). 2020 Jun 23; 11(6)Mladineo I, Hrabar J
  • The view of the nucleolus as a mere ribosomal factory has been recently expanded, highlighting its essential role in immune and stress-related signalling and orchestrating. It has been shown that the nucleolus structure, formed around nucleolus organiser regions (NORs) and attributed Cajal bodies, is prone to disassembly and reassembly correlated to various physiological and pathological stimuli.…
  • Heterochromatin Morphodynamics in Late Oogenesis and Early Embryogenesis of Mammals. [Review]
    Cells. 2020 Jun 19; 9(6)Bogolyubova I, Bogolyubov D
  • During the period of oocyte growth, chromatin undergoes global rearrangements at both morphological and molecular levels. An intriguing feature of oogenesis in some mammalian species is the formation of a heterochromatin ring-shaped structure, called the karyosphere or surrounded "nucleolus", which is associated with the periphery of the nucleolus-like bodies (NLBs). Morphologically similar heter…
  • Tiding-up the plant nuclear space: domains, function and dynamics. [Journal Article]
    J Exp Bot. 2020 Jun 18 [Online ahead of print]Santos AP, Gaudin V, … Farrona S
  • Understanding how the packaging of chromatin in the nucleus is regulated and organized to guide cellular programs, complex developmental programs and responses to environmental cues is a major question in biology. Technological advances have allowed a remarkable progress within this field over the last years. However, we still know very little how the 3D genome organization within the cell nucleu…
  • Nucleolus-Targeted Photodynamic Anticancer Therapy Using Renal-Clearable Carbon Dots. [Journal Article]
    Adv Healthc Mater. 2020 Jun 16 [Online ahead of print]Pang W, Jiang P, … Wei X
  • Photodynamic therapy (PDT), which utilizes light excited photosensitizers (PSs) to generate reactive oxygen species (ROS) and consequently ablate cancer cells or diseased tissue, has attracted a great deal of attention in the last decades due to its unique advantages. In order to further enhance PDT effect, PSs are functionalized to target specific sub-cellular organelles, but most PSs cannot tar…
  • [Cell morphological analysis of hepatosplenic T-cell lymphoma gamma-delta type]. [Journal Article]
    Zhonghua Yi Xue Za Zhi. 2020 Jun 16; 100(23):1805-1811.Wu P, Sun HP, … Wang H
  • CONCLUSIONS: Malignant cells of HSTCL γδ type have very distinct morphological features of mature lymphocytic neoplasm. The quality of Wright's stain, being short of complete cytochemical stains, lacking of awareness of this disease, and acute leukemia or MDS like appearance in some cases, result in the possibility of diagnostic error as malignant blast, and probably are main causes of misdiagnosis of HSTCL γδ type.
  • The circuitry between ribosome biogenesis and translation in stem cell function and ageing. [Journal Article]
    Mech Ageing Dev. 2020 Jun 09 [Online ahead of print]Sharifi S, Costa HFRD, Bierhoff H
  • Ribosome biogenesis takes place mainly in the nucleolus, a nuclear, non-membrane bound organelle forming around the gene arrays encoding ribosomal RNA (rRNA). Nucleolar activity comprises synthesis, processing and maturation of rRNAs, followed by their assembly with ribosomal proteins into pre-ribosomal particles. The final formation of translation-competent ribosomes in the cytoplasm is the prer…
  • Multiplexed imaging of nucleome architectures in single cells of mammalian tissue. [Journal Article]
    Nat Commun. 2020 Jun 09; 11(1):2907.Liu M, Lu Y, … Wang S
  • The three-dimensional architecture of the genome affects genomic functions. Multiple genome architectures at different length scales, including chromatin loops, domains, compartments, and lamina- and nucleolus-associated regions, have been discovered. However, how these structures are arranged in the same cell and how they are mutually correlated in different cell types in mammalian tissue are la…
  • Genetic and functional insights into CDA-I prevalence and pathogenesis. [Journal Article]
    J Med Genet. 2020 Jun 09 [Online ahead of print]Olijnik AA, Roy NBA, … Babbs C
  • CONCLUSIONS: Stability and interaction data suggest that C15orf41 may be the key determinant of CDA-I and offer insight into the mechanism underlying this disease. Both proteins share a common pathway likely to be present in a wide variety of cell types; however, nucleolar enrichment may provide a clue as to the erythroid specific nature of CDA-I. The surprisingly high predicted incidence of CDA-I suggests that better ascertainment would lead to improved patient care.
  • Linker histone variant H1T functions as a chromatin de-condenser on genic regions. [Journal Article]
    Biochem Biophys Res Commun. 2020 Jun 05 [Online ahead of print]Hayakawa K, Tani R, … Tanaka S
  • Linker histone H1 is mainly localized in the linker DNA region, between two nucleosome cores, and regulates chromatin structures linking gene expression. There are 11 variants in histone H1, and each variant has unique functions. Our previous study demonstrates that one of the H1 variants, H1T is mainly localized in the nucleolus and targets the rDNA repeat region. Moreover, H1T condenses the chr…
  • Mechano growth factor interacts with nucleolin to protect against cisplatin-induced neurotoxicity. [Journal Article]
    Exp Neurol. 2020 Jun 05 [Online ahead of print]Podratz JL, Tang JJ, … Madigan NN
  • Mechano growth factor (MGF) is an alternatively spliced form of insulin-like growth factor-1 (IGF-1) that has shown to be neuroprotective against 6-hydroxydopamine toxicity and ischemic injury in the brain. MGF also induces neural stem cell proliferation in the hippocampus and preserves olfactory function in aging mice. Cisplatin is a chemotherapy drug that induces peripheral neuropathy in 30-40%…
  • RNA-GPS Predicts SARS-CoV-2 RNA Localization to Host Mitochondria and Nucleolus. [Preprint]
    bioRxiv. 2020 Apr 28Wu K, Zou J, Chang HY
  • The SARS-CoV-2 coronavirus is driving a global pandemic, but its biological mechanisms are less well understood. SARS-CoV-2 is an RNA virus whose multiple genomic and subgenomic RNA (sgRNA) transcripts hijack the host cell's machinery, located across distinct cytotopic locations. Subcellular localization of its viral RNA could play important roles in viral replication and host antiviral immune re…
  • Aptamer AS1411 utilized for super-resolution imaging of nucleolin. [Journal Article]
    Talanta. 2020 Sep 01; 217:121037.Jing Y, Cai M, … Wang H
  • Nucleolin (NCL) is a multifunctional protein that mainly localizes in the nucleolus and also distributes in the nucleoplasm, cytoplasm and cell membrane. Most studies focus on its biofunctions in cell activities and diseases, however, its detailed distribution and organization pattern in situ remains obscure. Moreover, antibodies were commonly used to investigate NCL in cells. It is worth noting …
  • Enzymology, Histological and Ultrastructural Effects of Ar-Turmerone on Culex pipiens pallens Larvae. [Journal Article]
    Insects. 2020 May 30; 11(6)Liu J, Fernandez D, … Dai G
  • Our previous article demonstrated that ar-turmerone ((6S)-2-methyl-6-(4-methylphenyl)-2-hepten-4-one) extracted from Curcuma longa L. has a significant larvicidal activity against the fourth instar larvae of Culex pipiens pallens. To reveal the effects of ar-turmerone on C. pipiens pallens larvae, light microscopy and transmission electron microscopy were used to observe the histological and ultr…
  • The Coupling of Translational Control and Stress Responses. [Journal Article]
    J Biochem. 2020 Jun 02 [Online ahead of print]Houston R, Sekine S, Sekine Y
  • The translation of messenger RNA (mRNA) into protein is a multistep process by which genetic information transcribed into an mRNA is decoded to produce a specific polypeptide chain of amino acids. Ribosomes play a central role in translation by coordinately working with various translation regulatory factors and aminoacyl-transfer RNAs (tRNAs). A variety of stresses attenuate the ribosomal synthe…
  • Flexible RuII Schiff base complexes: G-quadruplex DNA binding and photo-induced cancer cell death. [Journal Article]
    Chemistry. 2020 Jun 02 [Online ahead of print]Gillard M, Weynand J, … Elias B
  • A series of new RuII Schiff base complexes built on the salphen moiety has been prepared. This includes four flexibile monometallic RuII compounds and six rigid bimetallic analogues that contain NiII, PdII or PtII cations into the salphen complexation site. Steady state luminescence titrations illustrated the capacity of the compounds to photoprobe G-quadruplex DNA. Moreover, the vast array of th…
  • The cellular model of albumin endocytosis uncovers link between membrane and nuclear proteins. [Journal Article]
    J Cell Sci. 2020 Jun 01 [Online ahead of print]Urae S, Harita Y, … Oka A
  • Cubilin (CUBN) and amnionless (AMN), expressed in kidney and intestine, form a multiligand receptor complex called CUBAM that plays a crucial role in albumin absorption. To date, the mechanism of albumin endocytosis mediated by CUBAM remains to be elucidated. Here, we established an assay to quantitatively evaluate the albumin uptake by CUBAM using cells expressing full-length CUBN, which elucida…
  • Berberine-induced nucleolar stress response in a human breast cancer cell line. [Journal Article]
    Biochem Biophys Res Commun. 2020 Jul 12; 528(1):227-233.Sakaguchi M, Kitaguchi D, … Tanaka S
  • We investigated the novel molecular mechanisms of the antitumor effect of berberine. In this study, two different human cell lines (breast cancer MCF7 cells and non-tumorigenic epithelial MCF12A cells) were treated with various concentrations of berberine. Treatment with 1 and 10 μM berberine inhibited proliferation with G0/G1 cell cycle arrest in both cell lines, and treatment with 100 μM berber…
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