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2,797 results
  • Therapeutic Approaches Targeting Nucleolus in Cancer. [Review]
    Cells 2019; 8(9)Carotenuto P, Pecoraro A, … Russo A
  • The nucleolus is a distinct sub-cellular compartment structure in the nucleus. First observed more than 200 years ago, the nucleolus is detectable by microscopy in eukaryotic cells and visible during the interphase as a sub-nuclear structure immersed in the nucleoplasm, from which it is not separated from any membrane. A huge number of studies, spanning over a century, have identified ribosome bi…
  • Spatio-temporal expression of ANK2 promotes cytokinesis in oocytes. [Journal Article]
    Sci Rep 2019; 9(1):13121Tetkova A, Jansova D, Susor A
  • In the absence of transcription, the regulation of gene expression in oocytes is controlled almost exclusively at the level of transcriptome and proteome stabilization, and translation. A subset of maternal transcripts is stored in a translationally dormant state in the oocyte, and temporally driven translation of specific mRNAs propel meiotic progression, oocyte-to-embryo transition and early em…
  • Dilution of contact frequency between superenhancers by loop extrusion at interfaces. [Journal Article]
    Soft Matter 2019Yamamoto T, Schiessel H
  • The loop extrusion theory predicts that cohesin acts as a molecular motor that extrudes chromatin fibers to produce loops. Hi-C experiments have detected relatively high contact frequencies between superenhancers. These probably result from the fact that superenhancers are localized at condensates of transcriptional activators and coactivators. The contact frequency between superenhancers is enha…
  • The NAE Pathway: Autobahn to the Nucleus for Cell Surface Receptors. [Review]
    Cells 2019; 8(8)Shah P, Chaumet A, … Bard FA
  • Various growth factors and full-length cell surface receptors such as EGFR are translocated from the cell surface to the nucleoplasm, baffling cell biologists to the mechanisms and functions of this process. Elevated levels of nuclear EGFR correlate with poor prognosis in various cancers. In recent years, nuclear EGFR has been implicated in regulating gene transcription, cell proliferation and DN…
  • Detection of mRNAs Anchored to the Nuclear Envelope During Export Inhibition in Living Cells. [Journal Article]
    Methods Mol Biol 2019; 2038:151-163Ben-Yishay R, Shav-Tal Y
  • Export of mRNA transcripts from the cell nucleus is a complex and multistep process, regulated by various proteins and control mechanisms. Recent studies have demonstrated the rapid passage of mRNA-protein complexes (mRNPs) through the nuclear pore complex (NPC) as well as the ability to detect mRNPs stalled at the NPC during inhibition of the mRNA export process. In this chapter, we describe way…
  • Rejuvenation of ribosomal RNA gene repeats at the nuclear pore. [Review]
    Curr Genet 2019Horigome C, Kobayashi T
  • The ribosomal RNA genes (rDNA) exist as tandem repeats in eukaryotes and are, therefore, highly unstable. Each rDNA unit includes a replication fork barrier site to avoid collisions between DNA replication forks and transcriptional machinery. However, because of this barrier, DNA double-strand breaks are induced at a relatively high frequency. If damage is repaired by the homologous recombination…
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