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87,100 results
  • An Alginate-Based Hydrogel with a High Angiogenic Capacity and a High Osteogenic Potential. [Journal Article]
    Biores Open Access. 2020; 9(1):174-182.Barre A, Naudot M, … Le Ricousse S
  • In bone tissue engineering, autologous cells are combined with osteoconductive scaffolds and implanted into bone defects. The major challenge is the lack of post-implantation vascular growth into biomaterial. The objective of the present study was to develop a new alginate-based hydrogel that enhances the regeneration of bone defects after surgery. The viability of human bone marrow-derived mesen…
  • LukS-PV Inhibits Hepatocellular Carcinoma Progression by Downregulating HDAC2 Expression. [Journal Article]
    Mol Ther Oncolytics. 2020 Jun 26; 17:547-561.Wang Z, Yu W, … Ma X
  • Hepatocellular carcinoma (HCC) is a common malignant tumor. LukS-PV is the S component of Panton-Valetine leukocidin (PVL), which is secreted by Staphylococcus aureus. This study investigated the effects of LukS-PV on the proliferation, apoptosis, and cell-cycle progression of HCC cells and the mechanisms of its activity. The HCC cells were treated with different LukS-PV concentrations in vitro. …
  • Targeted Antitumor Mechanism of C-PC/CMC-CD55sp Nanospheres in HeLa Cervical Cancer Cells. [Journal Article]
    Front Pharmacol. 2020; 11:906.Liu G, Xu X, … Li B
  • In vitro studies had shown that C-Phycocyanin (C-PC) inhibited cervical cancer HeLa cells growth. We constructed C-PC/CMC-CD55sp nanospheres using C-PC, Carboxymethyl Chitosan (CMC), and CD55 ligand peptide (CD55sp) to allow for targeted antitumor effects against HeLa cells in vitro and in vivo. The characteristics of the nanospheres were determined using FTIR, electron microscopy, and laser part…
  • miR-365a-5p suppresses gefitinib resistance in non-small-cell lung cancer through targeting PELI3. [Journal Article]
    Pharmacogenomics. 2020 Jul 08 [Online ahead of print]Li F, Li H, … He Y
  • Aim: Demonstrate the function of dysregulated miR-365a-5p-PELI3 signaling axis in the generation of gefitinib resistance during treatment for non-small-cell lung cancer (NSCLC). Patients & methods: All the NSCLC patients who participated in this research were recruited from the Second Hospital of Hebei Medical University (Shijiazhuang, China). PC9 cells and PC9GR cells were cultured for in vitro…
  • HEATR1 promotes proliferation in gastric cancer in vitro and in vivo. [Journal Article]
    Acta Biochim Biophys Sin (Shanghai). 2020 Jul 07 [Online ahead of print]Zhao J, Zhu Y, … Zhao G
  • HEAT repeat-containing protein 1 (HEATR1) is related to the progression of several cancers. However, the role of HEATR1 in gastric cancer (GC) remains unknown. In the present study, we aimed to detect the expression of HEATR1 in GC and identify its role. The expressions of HEATR1 in GC tissues were analyzed using The Cancer Genome Atlas database and by western blot analysis and immunohistochemist…
  • Long-term in vivo integrity and safety of 3D-bioprinted cartilaginous constructs. [Journal Article]
    J Biomed Mater Res B Appl Biomater. 2020 Jul 06 [Online ahead of print]Apelgren P, Amoroso M, … Kölby L
  • Long-term stability and biological safety are crucial for translation of 3D-bioprinting technology into clinical applications. Here, we addressed the long-term safety and stability issues associated with 3D-bioprinted constructs comprising a cellulose scaffold and human cells (chondrocytes and stem cells) over a period of 10 months in nude mice. Our findings showed that increasing unconfined comp…
  • Potent dual EGFR/Her4 tyrosine kinase inhibitors containing novel (1,2-dithiolan-4-yl)acetamides. [Journal Article]
    Bioorg Med Chem Lett. 2020 Aug 15; 30(16):127288.Mansour TS, Pallepati RR, Basetti V
  • Modifications at C6 and C7 positions of 3-cyanoquinolines 6 and 7 led to potent inhibitors of the ErbB family of kinases particularly against EGFRWT and Her4 enzymes in the radioisotope filter binding assay. The lead (4, SAB402) displayed potent dual biochemical activities with EGFRWT/Her4 IC50 ratio of 80 due to its potent inhibition of Her4 activity (IC50 0.03 nM), however, the selectivity towa…
  • A Comparative Study of Engineered Dermal Templates for Skin Wound Repair in a Mouse Model. [Journal Article]
    Int J Mol Sci. 2020 Jun 25; 21(12)Banakh I, Cheshire P, … Akbarzadeh S
  • Engineered dermal templates have revolutionised the repair and reconstruction of skin defects. Their interaction with the wound microenvironment and linked molecular mediators of wound repair is still not clear. This study investigated the wound bed and acellular "off the shelf" dermal template interaction in a mouse model. Full-thickness wounds in nude mice were grafted with allogenic skin, and …
  • Epigenetic Regulation of Gfi1 in Endocrine-Related Cancers: a Role Regulating Tumor Growth. [Journal Article]
    Int J Mol Sci. 2020 Jun 30; 21(13)Ashour N, Angulo JC, … Ropero S
  • Prostate and breast cancer constitute the most common cancers among men and women worldwide. The aging population is one of the main risk factors for prostate and breast cancer development and accumulating studies link aging with epigenetic changes. Growth factor independence-1 (Gfi1) is a transcriptional repressor with an important role in human malignancies, including leukemia, colorectal carci…
  • Cadmium chloride enhances cisplatin sensitivity in osteosarcoma cells by reducing FOXM1 expression. [Journal Article]
    Oncol Rep. 2020 Aug; 44(2):650-660.Hu K, Xie W, … Duan Y
  • Osteosarcoma is a highly malignant disease and is associated with a poor patient prognosis and a high mortality rate. Disease prognosis significantly correlates with chemotherapeutic responses. Cadmium is a heavy metal with specific effects on bone, but its benefits for osteosarcoma treatment have not been characterized. In the present study, cadmium chloride was used to treat MG63 osteosarcoma c…
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