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749,031 results
  • TNF-α blockers for the treatment of Kawasaki disease in children. [Review]
    Cochrane Database Syst Rev 2019; 8:CD012448Yamaji N, da Silva Lopes K, … Mori R
  • CONCLUSIONS: We found a limited number of RCTs examining the effect of TNF-α blockers for KD. In summary, low-certainty evidence indicates that TNF-α blockers have beneficial effects on treatment resistance and the adverse effect 'infusion reaction' after treatment initiation for KD when compared with no treatment or additional treatment with IVIG. Further research will add to the evidence base. Due to the small number of underpowered trials contributing to the analyses, the results presented should be treated with caution. Further large high quality trials with timing and type of TNF-α blockers used are needed to determine the effects of TNF-α blockers for KD.
  • Advanced sperm selection techniques for assisted reproduction. [Review]
    Cochrane Database Syst Rev 2019; 7:CD010461Lepine S, McDowell S, … Yazdani A
  • CONCLUSIONS: The evidence suggests that sperm selected by hyaluronic acid binding may have little or no effect on live birth or clinical pregnancy but may reduce miscarriage. We are uncertain of the effect of Zeta sperm selection on live birth, clinical pregnancy, and miscarriage due principally to the very low quality of the evidence for this intervention. We are uncertain of the effect of the other selection techniques on live birth, miscarriage, or pregnancy.Further high-quality studies, including the awaited data from the identified ongoing studies, are required to evaluate whether any of these advanced sperm selection techniques can be recommended for use in routine practice.
  • Routine monitoring of gastric residual for prevention of necrotising enterocolitis in preterm infants. [Review]
    Cochrane Database Syst Rev 2019; 7:CD012937Abiramalatha T, Thanigainathan S, Ninan B
  • CONCLUSIONS: Review authors found insufficient evidence as to whether routine monitoring of gastric residual reduces the incidence of necrotising enterocolitis because trial results are imprecise. Low-quality evidence suggests that routine monitoring of gastric residual increases the risk of feed interruption episodes, increases the time taken to reach full enteral feeds and to regain birth weight, and increases the number of total parenteral nutrition (TPN) days.Available data are insufficient to comment on other major outcomes such as incidence of invasive infection, parenteral nutrition-associated liver disease, mortality before discharge, extrauterine growth restriction at discharge, number of CVL days, and duration of hospital stay. Further randomised controlled trials are warranted to provide more precise estimates of the effects of routine monitoring of gastric residual on important outcomes, especially necrotising enterocolitis, in preterm infants.
  • Chronic Systemic Symptoms in Head and Neck Cancer Patients. [Journal Article]
    J Natl Cancer Inst Monogr 2019; 2019(53)Murphy BA, Wulff-Burchfield E, … Deng J
  • The systemic effects and manifestations of disease and treatment have been of interest for millennium. Until recently, basic and clinical research is just now reaching a watershed. Systemic symptoms usually do not occur in isolation but rather in clusters; however, much of the cutting-edge research pertaining to the etiology, mechanism, manifestations, and moderators of systemic symptoms in human…
  • Oral Pain in the Cancer Patient. [Journal Article]
    J Natl Cancer Inst Monogr 2019; 2019(53)Epstein JB, Miaskowski C
  • Oral pain due to cancer and associated treatments is common. The prevalence and severity of oral cancer is high. Painful oral mucositis develops in head and neck cancer patients following surgery and associated radiation therapy and/or chemotherapy. In addition, oral pain, including pain from mucositis, occurs in patients receiving chemotherapy for cancers of the hematopoietic system and cancers …
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