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941 results
  • [Black knee-ochronotic alterations in alkaptonuria]. [Journal Article]
    Unfallchirurg 2019Maurer E, Maurer M, … Kraus TM
  • This article presents the case of a 53-year-old male patient born in Sri Lanka, who presented to the outpatient unit with the suspicion of empyema of the knee joint. Within the framework of knee arthroscopy, the diagnosis of ochronosis was made and later confirmed by histopathological biopsy. The alkaptonuria is caused by a homogentisate 1,2-dioxygenase deficiency and leads to an accumulation of …
  • Corneal and Scleral Problems Caused by Skin-Lightening Creams. [Journal Article]
    Cornea 2019Hollick EJ, Igwe C, … Jones SM
  • CONCLUSIONS: We present previously unreported eye changes associated with the use of skin-lightening creams containing hydroquinone, with a triad of signs: posterior corneal striae radiating from 3 o'clock to 9 o'clock, thinning and plaques in the sclera, and a normal endothelial cell count. Similar pathological changes are seen in exogenous ochronosis, a recognized skin complication of hydroquinone, are seen in the sclera.
  • Exogenous ochronosis: the failure of depigmenting creams. [Journal Article]
    Dermatol Online J 2019; 25(4)Sánchez-Martínez EM, García-Briz MI, … Mateu-Puchades A
  • Exogenous ochronosis (EO) is an entity that manifests as black-bluish or grayish-brown cutaneous hyperpigmentation, which is a consequence of the deposition of ochronotic pigment with characteristic banana-like morphology between the collagen fibers of the dermis. Both the clinical presentation and histopathology appearance are superimposable with endogenous ochronosis or alcaptonuria, a heredita…
  • Endogenous ochronosis: when clinical suspicion prevails over histopathology. [Journal Article]
    Dermatol Online J 2019; 25(4)Sánchez-Martínez EM, García-Briz MI, … Mateu-Puchades A
  • Endogenous ochronosis (EO) or alkaptonuria is an inherited autosomal recessive disease caused by the insufficiency of the enzyme homogentisic acid dioxygenase. This disturbance causes an accumulation and increased renal excretion of homogentisic acid (AHG), which manifests as dark urine when it oxidizes on contact with air. Other clinical manifestations of OE are the result of the deposit of AHG …
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