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26 results
  • Oligonephronia and Wolf-Hirschhorn syndrome: A further observation. [Case Reports]
    Am J Med Genet A 2018; 176(2):409-414Gatto A, Ferrara P, … Zampino G
  • Wolf-Hirschhorn syndrome (WHS) is a rare chromosomal disorder caused by a partial deletion of chromosome 4 (4p16.3p16.2). We describe a case of a male 9 years old children with WHS proteinuria and hypertension. Laboratory data showed creatinine 1.05 mg/dl, GFR 65.9 ml/min/1.73 m2 , cholesterol 280 mg/dl, triglyceride 125 mg/dl with electrolytes in the normal range. Urine collection showed protein…
  • [Obesity-related glomerulopathy: Mechanisms of development, clinical course]. [Review]
    Ter Arkh 2017; 89(6):97-101Kutyrina IM
  • Obesity and overweight are recognized as epidemics of non-communicable diseases in the 21st century. The kidneys are a target organ for obesity, damage to which is considered to be an independent risk factor for the development of renal failure. Obesity-related glomerulopathy (OGP) is one of the types of renal injury in obesity, which is characterized by the development of proteinuria in patients…
  • Each niche has an actor: multiple stem cell niches in the preterm kidney. [Review]
    Ital J Pediatr 2015; 41:78Fanni D, Sanna A, … Fanos V
  • The preterm kidney cannot be simply considered as a kidney small in size: as compared to the adult kidney, the developing organ of the preterm infant is characterized by marked differences regarding the architecture and cell components. At macroscopy, fine linear demarcations indenting the renal surface characterize the fetal and preterm kidney. At microscopy, multiple major architectural changes…
  • [Premature kidneys and oligonephronia: long term repercussion]. [Journal Article]
    Rev Med Suisse 2014; 10(418):435-6, 438-41Wilhelm-Bals A, Chehade H, … Parvex P
  • The premature has a reduced number of nephrons. This condition, added to an immature renal function at birth, increases the vulnerability to hemodynamic changes, drug toxicity, and nephrocalcinosis. The oligonephronia worsens the risk to present in adulthood, hypertension and renal insufficiency. Nephrocalcinosis appears in the postnatal period, secondary to renal calcifications. This condition i…
  • Maturational regression of glomeruli determines the nephron population in normal mice. [Journal Article]
    Pediatr Res 2012; 72(3):241-8Zhong J, Perrien DS, … Ma J
  • CONCLUSIONS: Our study reveals that the tissue- and time-saving Weibel-Gomez method commonly used to assess glomerular number is valid only after P18. The data indicate that regulation of glomerular number by regression occurs in normally maturing mouse kidneys. These findings suggest that the process of glomerular regression could be therapeutically targeted to prevent oligonephronia, which otherwise predisposes to chronic kidney disease.
  • Alpha-tocopherol prevents intrauterine undernutrition-induced oligonephronia in rats. [Journal Article]
    Pediatr Nephrol 2011; 26(11):2019-29Vieira-Filho LD, Cabral EV, … Paixão AD
  • The role of α-tocopherol during nephrogenesis was investigated in rats subjected to maternal undernutrition, which reduces the number of nephrons. α-tocopherol (350 mg/kg, p.o.) was administered daily to well-nourished or malnourished Wistar dams during pregnancy, or to prenatal undernourished rats during lactation. The kidneys of 1- and 25-day-old offspring were removed to evaluate expression of…
  • Marked interindividual variability in renal maturation of preterm infants: lessons from autopsy. [Journal Article]
    J Matern Fetal Neonatal Med 2010; 23 Suppl 3:129-33Faa G, Gerosa C, … Fanos V
  • The kidney of low birthweight preterm infants is characterized by a reduced number of mature nephrons at birth. The aim of the present study was to determine whether, in preterms, active glomerulogenesis occurs in the postnatal period and whether it may compensate the reduced number of nephrons developed during the intrauterine life. Kidney samples were obtained at autopsy from 8 human fetuses, 1…
  • Developmental programming and hypertension. [Review]
    Curr Opin Nephrol Hypertens 2009; 18(2):144-52Nuyt AM, Alexander BT
  • CONCLUSIONS: While the complexity of the interactions between antenatal and postnatal influences on adult blood pressure is increasingly recognized, the importance of postnatal life in (positively) modulating developmental programming offers the hope of a critical window of opportunity to reverse programming and prevent or reduce related adult-onset diseases.
  • Duplication of chromosome 4q: renal pathology of two siblings. [Case Reports]
    Am J Med Genet A 2005; 134(3):330-3Otsuka T, Fujinaka H, … Tomizawa S
  • We report on two sibs with partial 4q trisomy: dup (4)(q35.2-q31.22) and their renal biopsy findings. Both of them show renal hypoplasia, although their chromosomal aberration lacks the minimal duplicated region 4q22-q23 and/or 4q25-q31.3, which had been shown to be associated with urogenital abnormalities and thumb malformations in previous reports. From the renal biopsy findings, the two sibs w…
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