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28 results
  • Oligonephronia and Wolf-Hirschhorn syndrome: A further observation. [Case Reports]
    Am J Med Genet A. 2018 02; 176(2):409-414.Gatto A, Ferrara P, … Zampino G
  • Wolf-Hirschhorn syndrome (WHS) is a rare chromosomal disorder caused by a partial deletion of chromosome 4 (4p16.3p16.2). We describe a case of a male 9 years old children with WHS proteinuria and hypertension. Laboratory data showed creatinine 1.05 mg/dl, GFR 65.9 ml/min/1.73 m2 , cholesterol 280 mg/dl, triglyceride 125 mg/dl with electrolytes in the normal range. Urine collection showed protein…
  • [Obesity-related glomerulopathy: Mechanisms of development, clinical course]. [Review]
    Ter Arkh. 2017; 89(6):97-101.Kutyrina IM
  • Obesity and overweight are recognized as epidemics of non-communicable diseases in the 21st century. The kidneys are a target organ for obesity, damage to which is considered to be an independent risk factor for the development of renal failure. Obesity-related glomerulopathy (OGP) is one of the types of renal injury in obesity, which is characterized by the development of proteinuria in patients…
  • Each niche has an actor: multiple stem cell niches in the preterm kidney. [Review]
    Ital J Pediatr. 2015 Oct 15; 41:78.Fanni D, Sanna A, … Fanos V
  • The preterm kidney cannot be simply considered as a kidney small in size: as compared to the adult kidney, the developing organ of the preterm infant is characterized by marked differences regarding the architecture and cell components. At macroscopy, fine linear demarcations indenting the renal surface characterize the fetal and preterm kidney. At microscopy, multiple major architectural changes…
  • [Premature kidneys and oligonephronia: long term repercussion]. [Journal Article]
    Rev Med Suisse. 2014 Feb 19; 10(418):435-6, 438-41.Wilhelm-Bals A, Chehade H, … Parvex P
  • The premature has a reduced number of nephrons. This condition, added to an immature renal function at birth, increases the vulnerability to hemodynamic changes, drug toxicity, and nephrocalcinosis. The oligonephronia worsens the risk to present in adulthood, hypertension and renal insufficiency. Nephrocalcinosis appears in the postnatal period, secondary to renal calcifications. This condition i…
  • Maturational regression of glomeruli determines the nephron population in normal mice. [Journal Article]
    Pediatr Res. 2012 Sep; 72(3):241-8.Zhong J, Perrien DS, … Ma J
  • CONCLUSIONS: Our study reveals that the tissue- and time-saving Weibel-Gomez method commonly used to assess glomerular number is valid only after P18. The data indicate that regulation of glomerular number by regression occurs in normally maturing mouse kidneys. These findings suggest that the process of glomerular regression could be therapeutically targeted to prevent oligonephronia, which otherwise predisposes to chronic kidney disease.
  • Alpha-tocopherol prevents intrauterine undernutrition-induced oligonephronia in rats. [Journal Article]
    Pediatr Nephrol. 2011 Nov; 26(11):2019-29.Vieira-Filho LD, Cabral EV, … Paixão AD
  • The role of α-tocopherol during nephrogenesis was investigated in rats subjected to maternal undernutrition, which reduces the number of nephrons. α-tocopherol (350 mg/kg, p.o.) was administered daily to well-nourished or malnourished Wistar dams during pregnancy, or to prenatal undernourished rats during lactation. The kidneys of 1- and 25-day-old offspring were removed to evaluate expression of…
  • Marked interindividual variability in renal maturation of preterm infants: lessons from autopsy. [Journal Article]
    J Matern Fetal Neonatal Med. 2010 Oct; 23 Suppl 3:129-33.Faa G, Gerosa C, … Fanos V
  • The kidney of low birthweight preterm infants is characterized by a reduced number of mature nephrons at birth. The aim of the present study was to determine whether, in preterms, active glomerulogenesis occurs in the postnatal period and whether it may compensate the reduced number of nephrons developed during the intrauterine life. Kidney samples were obtained at autopsy from 8 human fetuses, 1…
  • Developmental programming and hypertension. [Review]
    Curr Opin Nephrol Hypertens. 2009 Mar; 18(2):144-52.Nuyt AM, Alexander BT
  • CONCLUSIONS: While the complexity of the interactions between antenatal and postnatal influences on adult blood pressure is increasingly recognized, the importance of postnatal life in (positively) modulating developmental programming offers the hope of a critical window of opportunity to reverse programming and prevent or reduce related adult-onset diseases.
  • Duplication of chromosome 4q: renal pathology of two siblings. [Case Reports]
    Am J Med Genet A. 2005 Apr 30; 134(3):330-3.Otsuka T, Fujinaka H, … Tomizawa S
  • We report on two sibs with partial 4q trisomy: dup (4)(q35.2-q31.22) and their renal biopsy findings. Both of them show renal hypoplasia, although their chromosomal aberration lacks the minimal duplicated region 4q22-q23 and/or 4q25-q31.3, which had been shown to be associated with urogenital abnormalities and thumb malformations in previous reports. From the renal biopsy findings, the two sibs w…
  • Renal phenotype is exacerbated in Os and lpr double mutant mice. [Journal Article]
    Kidney Int. 2004 Sep; 66(3):1029-35.Jarad G, Lakhe-Reddy S, … Schelling JR
  • CONCLUSIONS: Os/+ mice with a superimposed lpr mutation displayed a more severe renal phenotype, rather than phenotype rescue, suggesting that Fas pathway activation is necessary to delete cells resulting from Os-dependent injury. We further propose that an Os-lpr gene interaction and/or mixed ROP-C3H genetic background regulated the renal phenotype, consistent with the concept that chronic renal disease pathogenesis reflects effects of multiple nephropathy susceptibility alleles.
  • Bilateral noncystic renal dysplasia in a Wistar-rat. [Journal Article]
    Exp Toxicol Pathol. 2003 Mar; 54(4):293-9.Ruehl-Fehlert CI, Deschl U, … Hartmann E
  • In a young Wistar rat a bilateral renal malformation was observed microscopically. Clinical chemistry gave no evidence of impaired kidney function. The kidney weight was slightly elevated and the kidneys showed no gross pathological changes. The lesion was located in the inner cortex of both kidneys and consisted of multiple foci of abnormal renal parenchyma similar to fetal kidney. Three compone…
  • In utero and in vitro exposure to beta-lactams impair kidney development in the rat. [Journal Article]
    J Am Soc Nephrol. 2000 May; 11(5):874-84.Nathanson S, Moreau E, … Gilbert T
  • beta-Lactam antibiotics are widely used because of their lack of toxicity in humans. However, during pregnancy, exposure of the fetus is likely to occur because beta-lactam antibiotics cross the placenta. The potential adverse effects of two penicillins (ampicillin, amoxicillin) and of one cephalosporin (ceftriaxone) were examined in rat kidney development. Two experimental approaches were used: …
  • Early defect in branching morphogenesis of the ureteric bud in induced nephron deficit. [Journal Article]
    Kidney Int. 1996 Sep; 50(3):783-95.Gilbert T, Cibert C, … Merlet-Bénichou C
  • Development of the metanephric kidney during embryogenesis can be altered both in vivo and in vitro by exposure to gentamicin, which may lead to oligonephronia. To study the role of the ureteric bud in nephron deficit genesis, we used metanephros organ cultures exposed to gentamicin as a model of impaired nephrogenesis. Ultrastructural localization of the antibiotic showed that by eight hours it …
  • Renal dysplasia associated with in utero exposure to gentamicin and corticosteroids. [Case Reports]
    Am J Med Genet. 1995 Jul 31; 58(1):91-3.Hulton SA, Kaplan BS
  • We report on a patient with renal cystic dysplasia, whose mother was given gentamicin and corticosteroids early in pregnancy. We speculate that these drugs may be implicated in abnormal nephrogenesis in humans. This speculation is based on gentamicin-induced small kidneys (oligonephronia) in the rat. Renal cystic disease has been demonstrated following glucocorticoid administration early in gesta…
  • Long-term effects of mild oligonephronia induced in utero by gentamicin in the rat. [Journal Article]
    Pediatr Res. 1991 Nov; 30(5):450-6.Gilbert T, Lelievre-Pegorier M, Merlet-Benichou C
  • Renal clearance studies and morphologic observations were performed in rats aged 14, 21, and 28 d and 3, 6, 9, and 12 mo born with a 20% reduction in nephron number after administration of 75 mg/kg/d of gentamicin to their mothers during the second half of gestation. Gentamicin was still present in urine 3 mo after birth. Morphologic damage characteristic of gentamicin accumulation was observed i…
  • Immediate and long-term renal effects of fetal exposure to gentamicin. [Review]
    Pediatr Nephrol. 1990 Jul; 4(4):445-50.Gilbert T, Lelievre-Pegorier M, Merlet-Benichou C
  • Aminoglycoside antibiotics, like gentamicin, given to pregnant females cross the placenta and accumulate in the fetal kidney, which, like the adult kidney, was found to be the major site of deposition. In young guinea-pigs whose mothers were given gentamicin during the week following nephrogenesis in the fetus, nephron growth was found to be retarded temporarily. In rats whose mothers were given …
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