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285,115 results
  • Use of GapmeRs for gene expression knockdowns in human primary resting CD4+ T cells. [Journal Article]
    J Immunol Methods 2019; :112674Abewe H, Deshmukh S, … Beliakova-Bethell N
  • Human primary resting CD4+ T cells are difficult to transfect while preserving viability. The present study evaluated gymnotic delivery and RNase H1-dependent gene expression knockdown mediated by antisense oligonucleotides, called GapmeRs. Exposure of primary resting CD4+ T cells to GapmeRs did not cause cell activation or affect cell viability. Gene expression knockdowns were stable at least up…
  • Damage removal and gap filling in nucleotide excision repair. [Journal Article]
    Enzymes 2019; 45:59-97Kemp MG
  • The nucleotide excision repair (NER) system removes a variety of types of helix-distorting lesions from DNA through a dual incision mechanism, in which the damaged nucleotide bases are excised in the form of a small, excised, damage-containing single-stranded DNA oligonucleotide (sedDNA). Damage removal leaves a gap in the DNA template that must then be filled in by the action of a DNA polymerase…
  • Modulating Immune Response with Nucleic Acid Nanoparticles. [Review]
    Molecules 2019; 24(20)Durbin JK, Miller DK, … Khisamutdinov EF
  • Nano-objects made of nucleic acids are becoming promising materials in the biomedical field. This is, in part, due to DNA and RNA self-assembly properties that can be accurately computed to fabricate various complex nanoarchitectures of 2D and 3D shapes. The nanoparticles can be assembled from DNA, RNA, and chemically modified oligonucleotide mixtures which, in turn, influence their chemical and …
  • Against expectations: Unassisted RNA adsorption onto negatively charged lipid bilayers. [Journal Article]
    Langmuir 2019Pannwitt S, Slama K, … Schneider D
  • The composition and physicochemical properties of biological membranes can be altered by diverse membrane integral and peripheral proteins as well as by small molecules, natural and synthetic. Diverse oligonucleotides have been shown to electrostatically interact with cationic and bivalent ion-loaded zwitterionic liposomes, leading to the formation of oligonucleotide-liposome aggregates. However,…
  • Practical Synthesis of Cap-4 RNA. [Journal Article]
    Chembiochem 2019Leiter J, Reichert D, … Micura R
  • Eukaryotic mRNAs possess 5' caps that are determining for their functions. A structural characteristic of 5' caps is methylation, with this feature already present in early eukaryotes such as trypanosoma. While the common cap-0 (m7GpppN) shows a rather simple methylation pattern, the trypanosomacap-4 displays seven distinguished additional methylations within the first four nucleosides. The study…
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