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24,772 results
  • The effects of caffeine on alcohol oral self-administration behavior in rats. [Journal Article]
    Physiol Behav. 2020 May 19 [Online ahead of print]Fernandes PR, Almeida FB, … Barros HMT
  • Caffeine and alcohol are some of the most commonly used psychoactive substances in the world, and are often used concomitantly. However, little is known about the effect of caffeine on alcohol consumption. Here, our aim was to investigate the co-exposure of alcohol mixed with caffeine in self-administration. Thirty-two male and thirty-two female Wistar rats were randomly divided into the followin…
  • Interpersonal and Group Contingencies. [Journal Article]
    Perspect Behav Sci. 2020 Mar; 43(1):115-135.Cariveau T, Muething CS, Trapp W
  • Responding by individuals in groups has been a prominent interest of the field of psychology. Experimental analyses of human behavior have provided some unique findings of the role that the environment, including both social and nonsocial stimuli, may have on individual responding. Cooperative and competitive contingencies, previously evaluated in animal and human operant research, provide unique…
  • Translations in Stimulus-Stimulus Pairing: Autoshaping of Learner Vocalizations. [Journal Article]
    Perspect Behav Sci. 2020 Mar; 43(1):57-103.da Silva SP, Williams AM
  • Stimulus-stimulus pairing (SSP) is a procedure used by behavior analysis practitioners that capitalizes on respondent conditioning processes to elicit vocalizations. These procedures usually are implemented only after other, more customary methods (e.g., standard echoic training via modeling) have been exhausted. Unfortunately, SSP itself has mixed research support, probably because certain as-ye…
  • Developing Improved Translational Models of Pain: A Role for the Behavioral Scientist. [Journal Article]
    Perspect Behav Sci. 2020 Mar; 43(1):39-55.Withey SL, Maguire DR, Kangas BD
  • The effective management of pain is a longstanding public health concern. Although opioids have been frontline analgesics for decades, they also have well-known undesirable effects that limit their clinical utility, such as abuse liability and respiratory depression. The failure to develop better analgesics has, in some ways, contributed to the escalating opioid epidemic that has claimed tens of …
  • Comparison of acute treatment with delayed-onset versus rapid-acting antidepressants on effort-related choice behaviour. [Journal Article]
    Psychopharmacology (Berl). 2020 May 20 [Online ahead of print]Griesius S, Mellor JR, Robinson ES
  • CONCLUSIONS: Motivational changes induced by dopaminergic manipulations and pre-feeding differentially affect effort choice behaviour. However, both conventional delayed-onset ADs and ketamine and scopolamine appear to have detrimental effects on motivation in this task at the higher doses tested without any evidence of specificity for effort-related choice behaviour, in contrast to their specificity in tasks which look at more cognitive aspects of reward processing.
  • Reduced Frequency of Knowledge of Results Enhances Acquisition of Skills in Rats as in Humans. [Journal Article]
    Front Psychol. 2020; 11:846.Reid AK, Swafford PGB
  • Macphail's (1985) null hypothesis challenged researchers to demonstrate any differences in intelligence between vertebrate species. Rather than focus on differences, we asked whether rats would show the same unexpected, counterintuitive features of skill learning observed in humans: Factors that degrade performance during acquisition often enhance performance in a subsequent retention/autonomy ph…
  • Signal detection: applying analysis methods from psychology to animal behaviour. [Journal Article]
    Philos Trans R Soc Lond B Biol Sci. 2020 Jul 06; 375(1802):20190480.Sumner CJ, Sumner S
  • Conspecific acceptance thresholds (Reeve 1989 Am. Nat.133, 407-435), which have been widely applied to explain ecological behaviour in animals, proposed how sensory information, prior information and the costs of decisions determine actions. Signal detection theory (Green & Swets 1966 Signal detection theory and psychophysics; SDT), which forms the basis of CAT models, has been widely used in psy…
  • Berberine Facilitates Extinction of Drug-Associated Behavior and Inhibits Reinstatement of Drug Seeking. [Journal Article]
    Front Pharmacol. 2020; 11:476.Shen X, Hui R, … Wen D
  • A high rate of relapse is a major clinical problem among drug-addicted individuals. Persistent traces of drug-associated reward memories contribute to intense craving and often trigger relapse. A number of interventions on drug-associated memories have shown significant benefits in relapse prevention. Among them are pre- or post-extinction pharmacological manipulations that facilitate the extinct…
  • Functional analysis and operant treatment of food guarding in a pet dog. [Journal Article]
    J Appl Behav Anal. 2020 May 10 [Online ahead of print]Mehrkam LR, Perez BC, … Dorey NR
  • The present study extended functional analysis (FA) methodology to human-directed resource guarding in a dog in an in-home setting. The subject underwent four conditions including control, attention, escape, and tangible, arranged in a modified FA. The results indicated multiply controlled resource guarding (i.e., escape, attention, and tangible functions). The experimenter then conducted a treat…
  • Translational cognitive neuroscience of dementia with touchscreen operant chambers. [Review]
    Genes Brain Behav. 2020 May 06 [Online ahead of print]Lee JH, Cho SY, Kim E
  • Translational cognitive neuroscience of dementia involves mainly two areas: the validation of newly-developed dementia animal models and the preclinical assessment of novel drug candidates in such model animals. To validate new animal models, a multi-domain panel (battery) approach is essential in that dementia is, by definition, not merely a memory disorder but rather a multi-domain cognitive/be…
  • Anti-instinctive Learning Behavior Revealed by Locomotion-Triggered Mild Heat Stress in Drosophila. [Journal Article]
    Front Behav Neurosci. 2020; 14:41.Sun R, Delly J, … Greenspan RJ
  • Anti-instinctive learning, an ability to modify an animal's innate behaviors in ways that go against one's innate tendency, can confer great evolutionary advantages to animals and enable them to better adapt to the changing environment. Yet, our understanding of anti-instinctive learning and its underlying mechanisms is still limited. In this work, we describe a new anti-instinctive learning beha…
  • Representation of Auditory Task Components and of Their Relationships in Primate Auditory Cortex. [Journal Article]
    Front Neurosci. 2020; 14:306.Knyazeva S, Selezneva E, … Brosch M
  • The current study aimed to resolve some of the inconsistencies in the literature on which mental processes affect auditory cortical activity. To this end, we studied auditory cortical firing in four monkeys with different experience while they were involved in six conditions with different arrangements of the task components sound, motor action, and water reward. Firing rates changed most strongl…
  • Cognitive disturbances in the cuprizone model of multiple sclerosis. [Journal Article]
    Genes Brain Behav. 2020 May 06 [Online ahead of print]Kopanitsa MV, Lehtimäki KK, … Nurmi A
  • Cognitive problems frequently accompany neurological manifestations of multiple sclerosis (MS). However, during screening of preclinical candidates, assessments of behaviour in mouse models of MS typically focus on locomotor activity. In the present study, we analysed cognitive behaviour of 9 to 10-week-old female C57Bl/6J mice orally administered with the toxin cuprizone that induces demyelinati…
  • 7,8-Dihydroxyflavone Enhances Cue-Conditioned Alcohol Reinstatement in Rats. [Journal Article]
    Brain Sci. 2020 May 01; 10(5)Hogarth SJ, Djouma E, van den Buuse M
  • Alcohol use disorder (AUD) is a detrimental disease that develops through chronic ethanol exposure. Reduced brain-derived neurotrophic factor (BDNF) expression has been associated with AUD and alcohol addiction, however the effects of activation of BDNF signalling in the brain on voluntary alcohol intake reinstatement and relapse are unknown. We therefore trained male and female Sprague Dawley ra…
  • Age-related shifts in gut microbiota contribute to cognitive decline in aged rats. [Journal Article]
    Aging (Albany NY). 2020 May 01; 12(9):7801-7817.Li Y, Ning L, … Zhang C
  • Cognitive function declines during the aging process, meanwhile, gut microbiota of the elderly changed significantly. Although previous studies have reported the effect of gut microbiota on learning and memory, all the reports were based on various artificial interventions to change the gut microbiota without involvement of aging biological characteristics. Here, we investigated the effect of age…
  • Revealing a compulsive phenotype in cholinergic M4-/- mice depends on the inter-trial interval initiation settings in a five choice serial reaction time task. [Journal Article]
    Behav Brain Res. 2020 Apr 25; 389:112649.Justinussen J, Dall C, … Thomsen M
  • CONCLUSIONS: We did not observe differences in premature or perseverative responses in M4-/- mice in either condition, but found evidence of reward-related compulsive behavior in M4-/- mice. In the head-in condition, M4-/- mice were slower to acquire the 5CSRTT, had more omissions, and had longer correct response latencies than wildtype mice. In the head-out condition, genotypes did not differ in training, but M4-/- mice showed small decreases in accuracy. Our findings demonstrate that ITI initiation settings contribute to different training durations and tested behaviors in M4-/- mice, suggesting ITI initiation settings are an important consideration for the general use of the 5CSRTT.
  • Optimal spectral templates for triggered feedback experiments. [Journal Article]
    PLoS One. 2020; 15(4):e0228512.Kulkarni AS, Troyer TW
  • In the field of songbird neuroscience, researchers have used playback of aversive noise bursts to drive changes in song behavior for specific syllables within a bird's song. Typically, a short (~5-10 msec) slice of the syllable is selected for targeting and the average spectrum of the slice is used as a template. Sounds that are sufficiently close to the template are considered a match. If other …
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