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(opioid analgesics)
120,868 results
  • Fatalities in poisoned patients managed by medical toxicologists. [Journal Article]
    Clin Toxicol (Phila) 2019; :1-4Friedman N, Shoshani-Levy M, … Toxicology Investigators Consortium
  • CONCLUSIONS: Most ToxIC registry exposures resulting in death involve intentional exposure, without sex predominance. One in 10 fatalities involved a child. Analgesics, non-opioids, and opioids are the most commonly implicated agents in both fatal and non-fatal intoxications, which highlights the centrality of these agents as major sources of both morbidity and mortality.
  • A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor. [Journal Article]
    Proc Natl Acad Sci U S A 2019Dekan Z, Sianati S, … Christie MJ
  • An Australian estuarine isolate of Penicillium sp. MST-MF667 yielded 3 tetrapeptides named the bilaids with an unusual alternating LDLD chirality. Given their resemblance to known short peptide opioid agonists, we elucidated that they were weak (K i low micromolar) μ-opioid agonists, which led to the design of bilorphin, a potent and selective μ-opioid receptor (MOPr) agonist (K i 1.1 nM). In sha…
  • Association between buprenorphine/naloxone and high-dose opioid analgesic prescribing in Kentucky, 2012-2017. [Journal Article]
    Drug Alcohol Depend 2019; 205:107606Luu H, Slavova S, … Bush H
  • CONCLUSIONS: Our results indicate a significant reciprocal relationship between HDOAP and buprenorphine/naloxone prescribing and a clinically meaningful effect of buprenorphine/naloxone prescribing on reducing HDOAP. Future studies on buprenorphine/naloxone treatment expansion should take into account this bi-directional association in the context of longitudinal data and evaluate for public health benefits beyond the reduction of HDOAP.
  • Inpatient pain management in sickle cell disease. [Journal Article]
    Am J Health Syst Pharm 2019Zassman SM, Zamora FJ, Roberts JD
  • CONCLUSIONS: SCD is an inherited blood disorder characterized by episodic acute pain known as vaso-occlusive crisis (VOC), which is the most common reason for emergency department visits and hospital admissions in patients with SCD; these patients are often treated with parenteral opioids on admission and then transitioned to oral opioids prior to discharge. In this report, experience with use of the oral tier approach in 3 patients with SCD hospitalized for management of VOC is reported. As per usual practice, acute pain was initially managed with parenteral opioids via patient-controlled analgesia (PCA). Once pain control was established, an oral tier was added. The oral tier consisted of 3 orders. The first order was for an oral opioid, to be administered every 3 hours on a scheduled basis; however, the patient could refuse 1 or more of these scheduled doses. Two additional orders specified that the patients could receive additional oral opioids in incremental doses for moderate (grade 4-7) or severe (grade 8-10) pain if appropriate. To facilitate transition to an oral regimen with which the patients might be discharged, they were encouraged to use oral opioids in preference to parenteral opioids. Opioid usage and average daily pain scores for the 3 patients are reported.Healthcare providers can use the oral tier approach to facilitate rapid inpatient conversion from i.v. PCA to oral opioids while providing adequate pain control in patients with SCD who develop VOC.
  • Use and Efficacy of Analgesic Agents in Sheep (Ovis aries) Used in Biomedical Research. [Journal Article]
    J Am Assoc Lab Anim Sci 2019Stillman MW, Whittaker AL
  • Sheep (Ovis aries) are widely used as large animal models in biomedical research. However, current literature on the use ofanalgesics in sheep generally focuses on an industry or farm level of use. This structured review evaluates use and efficacy of analgesics administered to sheep in a biomedical research setting. Electronic databases were searched with terms related to analgesia in research sh…
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