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4,703 results
  • Magnesium Fluoride Forms Unique Protein Corona for Efficient Delivery of Doxorubicin into Breast Cancer Cells. [Journal Article]
  • TToxics 2019 Feb 22; 7(1)
  • Al-Busaidi H, Karim ME, … Chowdhury EH
  • CONCLUSIONS: Particle size on average was estimated to be <200 nm. The crystals were cubic in shape. The particles were pH-sensitive and capable of releasing doxorubicin in increasing acidic conditions. MgF₂ nanocrystals were safe in lower concentrations, and when bound to doxorubicin, enhanced its uptake. The protein corona formed around MgF₂ nanoparticles lacks typical opsonins but contains some dysopsonins.A drug delivery vector in the form of MgF₂ nanocrystals has been developed to transport doxorubicin into breast cancer cells. It is pH-sensitive (allowing for controlled release), size-modifiable, simple and cheap to produce.
  • Association of serum levels of C-reactive protein with CRP-717 T/C polymorphism and viremia in HCV and HBV carriers. [Journal Article]
  • RSRev Soc Bras Med Trop 2019 Feb 21; 52:e20180455
  • Moura TCF, Amoras EDSG, … Vallinoto ACR
  • CONCLUSIONS: The present results demonstrated a close relationship between the ability of the virus to replicate and cause liver damage and low serum concentrations of C-reactive protein. Future research may determine if these results can be interpreted as a possible form of escape for the virus by decreasing its action as an opsonin and decreasing phagocytosis, which are functions of C-reactive protein in the immune response.
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