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4,722 results
  • A simple, ex vivo phagocytosis assay of Plasmodium vivax merozoites by flow cytometry. [Journal Article]
    Mem Inst Oswaldo Cruz 2019; 114:e190158Farias E, Bezerra F, … Nogueira PA
  • As phagocytosis is the first line of defense against malaria, we developed a phagocytosis assay with Plasmodium vivax (P. vivax) merozoites that can be applied to evaluate vaccine candidates. Briefly, after leukocyte removal with loosely packed cellulose powder in a syringe, P. vivax trophozoites matured to the merozoite-rich schizont stages in the presence of the E64 protease inhibitor. The Perc…
  • Myeloid SOCS3 Deficiency Regulates Angiogenesis via Enhanced Apoptotic Endothelial Cell Engulfment. [Journal Article]
    J Innate Immun 2019; :1-9Korovina I, Neuwirth A, … Klotzsche-von Ameln A
  • Mononuclear phagocytes, such as macrophages and microglia, are key regulators of organ homeostasis including vascularization processes. Here, we investigated the role of the suppressor of cytokine signaling 3 (SOCS3) in myeloid cells as a regulator of mononuclear phagocyte function and their interaction with endothelial cells in the context of sprouting angiogenesis. As compared to SOCS3-sufficie…
  • The diversity of pattern recognition receptors (PRRs) involved with insect defense against pathogens. [Review]
    Curr Opin Insect Sci 2019; 33:105-110Wang X, Zhang Y, … Zhang J
  • Through evolution, selection pressures cause both insects and the pathogens attacking them to adapt so that they will both survive and this has been called the co-evolutionary 'arms race'. Insects expand their repertoire of pattern recognition receptors (PRRs), a fundamental and core component of their immune systems, to adapt to the constantly changing and unpredictable diversity of pathogens. I…
  • Chemistry Routes for Copolymer Synthesis Containing PEG for Targeting, Imaging, and Drug Delivery Purposes. [Review]
    Pharmaceutics 2019; 11(7)Rahme K, Dagher N
  • Polyethylene glycol (PEG) is one of the most frequently used polymers for coating nanocarriers to enhance their biocompatibility, hydrophilicity, stability, and biodegradability. PEG is now considered to be among the best biocompatible polymers. It offers sterical hindrance against other nanoparticles and blood components such as opsonin, preventing their macrophage phagocytosis and resulting in …
  • Biomaterial Surface Hydrophobicity-Mediated Serum Protein Adsorption and Immune Responses. [Journal Article]
    ACS Appl Mater Interfaces 2019; 11(31):27615-27623Visalakshan RM, MacGregor MN, … Vasilev K
  • The nature of the protein corona forming on biomaterial surfaces can affect the performance of implanted devices. This study investigated the role of surface chemistry and wettability on human serum-derived protein corona formation on biomaterial surfaces and the subsequent effects on the cellular innate immune response. Plasma polymerization, a substrate-independent technique, was employed to cr…
  • Broad-spectrum capture of clinical pathogens using engineered Fc-mannose-binding lectin enhanced by antibiotic treatment. [Journal Article]
    F1000Res 2019; 8:108Seiler BT, Cartwright M, … Ingber DE
  • CONCLUSIONS: The efficiency of pathogen detection and variation between binding of different strains of the same species could be improved by treating the bacteria with antibiotics, or mechanical disruption using a bead mill, prior to FcMBL capture to reveal previously concealed binding sites within the bacterial cell wall. As FcMBL can bind to pathogens and PAMPs in urine as well as blood, its broad-binding capability could be leveraged to develop a variety of clinically relevant technologies, including infectious disease diagnostics, therapeutics, and vaccines.
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