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Unbound Medicine.
(optokinetic)
3,607 results
  • Speed and accuracy of saccades in patients with glaucoma evaluated using an eye tracking perimeter. [Journal Article]
    BMC Ophthalmol. 2020 Jun 30; 20(1):259.Tatham AJ, Murray IC, … Minns RA
  • CONCLUSIONS: Patients with glaucoma had significant differences in eye movements compared to healthy subjects, with a relationship between slower and less accurate eye movements and worse glaucoma severity. However, in a multivariable model, eye movement parameters were not of additional benefit in differentiating eyes with glaucoma from healthy controls.
  • Vertical Optokinetic Stimulation Induces Diagonal Eye Movements in Patients with Idiopathic Infantile Nystagmus. [Journal Article]
    Invest Ophthalmol Vis Sci. 2020 Jun 03; 61(6):14.Economides JR, Suh YW, … Horton JC
  • CONCLUSIONS: In patients with congenital motor nystagmus, a vertical noise pattern drives a diagonal nystagmus. This appears to arise because of crosstalk between the vertical and horizontal components of the optokinetic system. This abnormal response to vertical stimulation is not caused by strabismus because it occurs in patients with infantile nystagmus without strabismus. Moreover, it is absent in patients with strabismus and no spontaneous nystagmus.
  • Perception of postural verticality in roll and pitch while sitting and standing in healthy subjects. [Journal Article]
    Neurosci Lett. 2020 Jun 21; 730:135055.Bergmann J, Bardins S, … Jahn K
  • Assessment of verticality perception is increasingly used in patients with disorders of upright body orientation, e.g. in pusher behavior after hemispheric stroke or in retropulsion in neurovascular or degenerative diseases. The subjective postural vertical (SPV) assesses the individual's perceived upright body orientation in space and can be determined in a sitting or a standing position. As som…
  • Corneal stromal stem cells restore transparency after N2 injury in mice. [Journal Article]
    Stem Cells Transl Med. 2020 May 07 [Online ahead of print]Ghoubay D, Borderie M, … Borderie VM
  • Corneal scarring associated with various corneal conditions is a leading cause of blindness worldwide. The present study aimed to test the hypothesis that corneal stromal stem cells have a therapeutic effect and are able to restore the extracellular matrix organization and corneal transparency in vivo. We first developed a mouse model of corneal stromal scar induced by liquid nitrogen (N2) applic…
  • Mal de débarquement syndrome – “sickness of disembarkment” [Journal Article]
    Orv Hetil. 2020 05 01; 161(20):846-851.Varga Z, Horváth B, … Horváth T
  • Mal de débarquement syndrome is an uncommon vestibular disorder characterized by a constant sensation of swaying or motion after one disembarks from a vehicle such as a ship or plane, however, spontaneous onset also appears. These symptoms temporarily subside when the patient is subjected again to passive motion like driving a car. Chronic fatigue, anxiety, and depression are frequently associate…
  • Vestibular Test Results of a Patient with Cerebral Microangiopathy and Idiopathic Thrombocytopenia. [Journal Article]
    J Am Acad Audiol. 2020 Apr 27 [Online ahead of print]Myers B, Creegan D, Hoyos E
  • CONCLUSIONS: These findings emphasize the importance of comprehensive vestibular evaluations of patients with CM, ITP, and complaints of instability. Identification and quantification of residual peripheral vestibular function as well as central system involvement can provide significant information pertinent to falls risk reduction and vestibular rehabilitation strategies, outcomes, and goals.
  • Velocity storage mechanism drives a cerebellar clock for predictive eye velocity control. [Journal Article]
    Sci Rep. 2020 Apr 24; 10(1):6944.Miki S, Urase K, … Hirata Y
  • Predictive motor control is ubiquitously employed in animal kingdom to achieve rapid and precise motor action. In most vertebrates large, moving visual scenes induce an optokinetic response (OKR) control of eye movements to stabilize vision. In goldfish, the OKR was found to be predictive after a prolonged exposure to temporally periodic visual motion. A recent study showed the cerebellum necessa…
  • Simulation of a Human-Scale Cerebellar Network Model on the K Computer. [Journal Article]
    Front Neuroinform. 2020; 14:16.Yamaura H, Igarashi J, Yamazaki T
  • Computer simulation of the human brain at an individual neuron resolution is an ultimate goal of computational neuroscience. The Japanese flagship supercomputer, K, provides unprecedented computational capability toward this goal. The cerebellum contains 80% of the neurons in the whole brain. Therefore, computer simulation of the human-scale cerebellum will be a challenge for modern supercomputer…
  • A Neuroanatomically Grounded Optimal Control Model of the Compensatory Eye Movement System in Mice. [Journal Article]
    Front Syst Neurosci. 2020; 14:13.Holland PJ, Sibindi TM, … Donchin O
  • We present a working model of the compensatory eye movement system in mice. We challenge the model with a data set of eye movements in mice (n =34) recorded in 4 different sinusoidal stimulus conditions with 36 different combinations of frequency (0.1-3.2 Hz) and amplitude (0.5-8°) in each condition. The conditions included vestibular stimulation in the dark (vestibular-ocular reflex, VOR), optok…
  • Humans use Optokinetic Eye Movements to Track Waypoints for Steering. [Journal Article]
    Sci Rep. 2020 Mar 06; 10(1):4175.Lappi O, Pekkanen J, … Virtanen JP
  • It is well-established how visual stimuli and self-motion in laboratory conditions reliably elicit retinal-image-stabilizing compensatory eye movements (CEM). Their organization and roles in natural-task gaze strategies is much less understood: are CEM applied in active sampling of visual information in human locomotion in the wild? If so, how? And what are the implications for guidance? Here, we…
  • Pupil response is modulated by attention shift in optokinetic nystagmus. [Journal Article]
    J Opt Soc Am A Opt Image Sci Vis. 2020 Mar 01; 37(3):361-367.Kanari K
  • Pupil size is modulated not only by the luminance at the eye position but also by that at the attended location. This study aims to examine whether pupil changes also correspond to the luminance at the spatial location to which the attention is shifted in optokinetic nystagmus. The test stimulus consisted of randomly positioned dots that moved to the left or to the right on a display screen that …
  • Mutation in Bmpr1b Leads to Optic Disc Coloboma and Ventral Retinal Gliosis in Mice. [Journal Article]
    Invest Ophthalmol Vis Sci. 2020 02 07; 61(2):44.Yan X, Atorf J, … German Mouse Clinic Consortium
  • CONCLUSIONS: Our study demonstrates that BMPR1B is necessary for the development of the optic nerve and ventral retina. This study could also indicate a new mechanism in the formation of retinal gliosis; it opens new routes for its treatment eventually preventing scar formation in the retina.
  • Can auditory cues improve visuo-spatial neglect? Results of two pilot studies. [Journal Article]
    Neuropsychol Rehabil. 2020 Feb 27 [Online ahead of print]Schenke N, Franke R, … Hildebrandt H
  • Although neglect is known to be a multimodal deficit, current interventions often address the visual modality only. Experimental studies, however, found that neglect patients can partially overcome their spatial inattention temporarily when being exposed to auditory cues that move towards the neglected side of space. Two pilot studies investigated the impact of dynamic auditory cueing on egocentr…
  • Exposure to Crude Oil Induces Retinal Apoptosis and Impairs Visual Function in Fish. [Journal Article]
    Environ Sci Technol. 2020 03 03; 54(5):2843-2850.Magnuson JT, Bautista NM, … Roberts AP
  • Polycyclic aromatic hydrocarbons (PAHs) present in crude oil are known to impair visual development in fish. However, the underlying mechanism of PAH-induced toxicity to the visual system of fish is not understood. Embryonic zebrafish (Danio rerio) at 4 h post fertilization were exposed to weathered crude oil and assessed for visual function using an optokinetic response, with subsequent samples …
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