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(orally disintegrating)
599 results
  • Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs. [Journal Article]
    Pharmaceutics 2019; 11(8)Sipos E, Kósa N, … Zelkó R
  • Aceclofenac-loaded poly(vinyl-pyrrolidone)-based nanofiber formulations were prepared by electrospinning to obtain drug-loaded orally disintegrating webs to enhance the solubility and dissolution rate of the poorly soluble anti-inflammatory active that belongs to the BCS Class-II. Triethanolamine-containing ternary composite of aceclofenac-poly(vinyl-pyrrolidone) nanofibers were formulated to exe…
  • The first-generation phosphodiesterase 5 inhibitors and their pharmacokinetic issue. [Review]
    Andrology 2019Zucchi A, Costantini E, … Nocentini G
  • CONCLUSIONS: We conclude that several ODT and ODF formulations can improve the 'discretion' issue because they are taken without water, but they have similar pharmacokinetics to corresponding film-coated tablet formulations. One ODF formulation of sildenafil was characterized by a shorter Tonset and could potentially increase patient satisfaction following treatment. However, more clinical studies are needed to confirm the findings. Surfactants and ascorbic acid appear to be crucial excipients for achieving a high absorption rate, but more studies are needed.
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