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Unbound Medicine.
(orally disintegrating)
636 results
  • Advances in drug delivery systems: Work in progress still needed? [Review]
    Int J Pharm X. 2020 Dec; 2:100050.Laffleur F, Keckeis V
  • A new era of science and technology has emerged in pharmaceutical research with focus on developing novel drug delivery systems for oral administration. Conventional dosage forms like tablets and capsules are associated with a low bioavailability, frequent application, side effects and hence patient noncompliance. By developing novel strategies for drug delivery, researchers embraced an alternati…
  • Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets. [Journal Article]
    Pharmaceuticals (Basel). 2020 May 18; 13(5)Alejandro B, Guillermo T, Ángeles PM
  • This work proposes the design of novel oral disintegrating tablets (ODTs) of loperamide HCl with special emphasis on disintegration and dissolution studies. The main goal was augmenting the adherence to treatment of diseases which happen with diarrhea in soldiers who are exposed to diverse kinds of hostile environments. Optimized orally disintegrating tablets were prepared by the direct compressi…
  • A physiologically-based drug absorption modeling for orally disintegrating tablets. [Journal Article]
    Eur J Pharm Biopharm. 2020 Jul; 152:1-9.Kambayashi A, Kiyota T
  • The aim of this research was to simulate oral pharmacokinetic (PK) profiles of atorvastatin from orally disintegrating tablets (ODTs) dosed without water ingestion in fasted humans. The in vitro dissolution profiles of three different formulations of ODTs were evaluated with fasted state biorelevant media using a paddle dissolution apparatus, and the results were coupled with an in silico model t…
  • Rimegepant: First Approval. [Review]
    Drugs. 2020 May; 80(7):741-746.Scott LJ
  • The orally disintegrating tablet (ODT) formulation of rimegepant (NURTEC ODT®) is a small molecule, highly-selective, calcitonin gene-related peptide antagonist that was developed by Biohaven Pharmaceutical Holding Company Ltd as an acute treatment for migraine. A conventional tablet formulation of the drug is being investigated for the acute treatment (under FDA review in the USA) and prevention…
  • Fast Dissolving/Disintegrating Dosage Forms of Natural Active Compounds and Alternative Medicines. [Journal Article]
    Recent Pat Drug Deliv Formul. 2020 Mar 24 [Online ahead of print]Singh A, Kharb V, Saharan VA
  • Fast Dissolving/Disintegrating Dosage Forms (FDDFs) are a group of dosage forms which dissolve/disintegrate quickly leading to fast distribution of active ingredient at site of administration thereby provides ease of oral ingestion of solid unit dosage forms and have the potential to enhance transmucosal absorption. Objective of this review is to explore the application of various FDDFs to delive…
  • 3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients. [Journal Article]
    Pharmaceutics. 2020 Feb 19; 12(2)Awad A, Yao A, … Basit AW
  • Visual impairment and blindness affects 285 million people worldwide, resulting in a high public health burden. This study reports, for the first time, the use of three-dimensional (3D) printing to create orally disintegrating printlets (ODPs) suited for patients with visual impairment. Printlets were designed with Braille and Moon patterns on their surface, enabling patients to identify medicati…
  • New advances in the characterization of lyophilised orally disintegrating tablets. [Journal Article]
    Int J Pharm. 2020 Apr 15; 579:119153.Vanbillemont B, Everaert H, De Beer T
  • Orally disintegrating tablets (ODTs) produced by lyophilisation have a unique porous structure which leads to a favorable orodispersable functionality. They possess ultra-fast disintegration kinetics, have acceptable mechanical strength and give a smooth mouth texture. Only limited literature is available on the characterization of ODTs and even fewer on lyophilised tablets. The suitability of a …
  • Subdivision of modified-release tablets: state-of-the-art and future perspectives. [Editorial]
    Ther Deliv. 2020 May; 11(5):285-287.Cunha-Filho M, Gelfuso GM, Gratieri T
  • Tablet splitting is a practice disseminated among health professionals for dose adjustments, swallowing facilitation or even treatment cost reduction. Nevertheless, tablets not designed for this purpose cause imprecise dosage and stability loss with important therapeutic repercussions. Novel technologies of modified drug release tablets have come to market including new materials and innovative p…
  • Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron. [Journal Article]
    Pharmaceutics. 2020 Jan 30; 12(2)Allahham N, Fina F, … Goyanes A
  • The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug-cyclodextrin complexes and then combined with the filler mannitol. Two 3D printed formulations with different levels of mannitol were prepared and tested, and a commercial on…
  • Effect of food thickener and jelly wafer on the pharmacokinetics of levofloxacin orally disintegrating tablets. [Journal Article]
    Heliyon. 2019 Nov; 5(11):e02764.Tomita T, Yamaguchi A, … Kudo K
  • This study was designed to determine the effects of a food thickener and deglutition aid jelly for oral administration, jelly wafer, on the pharmacokinetics of levofloxacin orally disintegrating tablets. With an increase in immersion time, the disintegration time of levofloxacin orally disintegrating tablets immersed in food thickener was prolonged, whereas that of the tablets immersed in jelly w…
  • Preparation and evaluation of novel multi-channel orally disintegrating tablets. [Journal Article]
    Eur J Pharm Sci. 2020 Jan 15; 142:105108.Yu J, Shan X, … Hu L
  • In this study, novel orally disintegrating tablets (ODTs) with multi-channel structure were designed to provide a rapid disintegration and subsequently drug dissolution. The ODTs were prepared using conventional wet compression through perforating channels with a special multi-channel mold. A modified sieve method was used in disintegration test as a quick screening tool during formulation evalua…
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