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508,122 results
  • Cell organelles and yeast longevity: an intertwined regulation. [Review]
    Curr Genet 2019Banerjee R, Joshi N, Nagotu S
  • Organelles are dynamic structures of a eukaryotic cell that compartmentalize various essential functions and regulate optimum functioning. On the other hand, ageing is an inevitable phenomenon that leads to irreversible cellular damage and affects optimum functioning of cells. Recent research shows compelling evidence that connects organelle dysfunction to ageing-related diseases/disorders. Studi…
  • Modelling transport and mean age of dense core vesicles in large axonal arbours. [Journal Article]
    Proc Math Phys Eng Sci 2019; 475(2228):20190284Kuznetsov IA, Kuznetsov AV
  • A model simulating the transport of dense core vesicles (DCVs) in type II axonal terminals of Drosophila motoneurons has been developed. The morphology of type II terminals is characterized by the large number of en passant boutons. The lack of both scaled-up DCV transport and scaled-down DCV capture in boutons results in a less efficient supply of DCVs to distal boutons. Furthermore, the large n…
  • MGSE regulates crosstalk from the mucin pathway to the TFE3 pathway of the Golgi stress response. [Journal Article]
    Cell Struct Funct 2019Jamaludin MI, Wakabayashi S, … Yoshida H
  • The Golgi apparatus is an organelle where membrane or secretory proteins receive post-translational modifications such as glycosylation and sulfation, after which the proteins are selectively transported to their final destinations through vesicular transport. When the synthesis of secretory or membrane proteins is increased and overwhelms the capacity of the Golgi (Golgi stress), eukaryotic cell…
  • Mitochondria orchestrate proteostatic and metabolic stress responses. [Review]
    EMBO Rep 2019; :e47865Andréasson C, Ott M, Büttner S
  • The eukaryotic cell is morphologically and functionally organized as an interconnected network of organelles that responds to stress and aging. Organelles communicate via dedicated signal transduction pathways and the transfer of information in form of metabolites and energy levels. Recent data suggest that the communication between organellar proteostasis systems is a cornerstone of cellular str…
  • Ultrastructural characterization of damage in the basement membrane of facial melasma. [Journal Article]
    Arch Dermatol Res 2019Espósito ACC, Brianezi G, … Miot HA
  • The pathogenesis of melasma is not fully understood, and the role of skin basement membrane zone (BMZ) alterations in disease development and the maintenance of hypermelanogenesis are also poorly known. We performed a comparative study to characterize the ultrastructural alterations that occur in BMZ in melasma and adjacent normal skin, as well as we discuss the implications of these changes in t…
  • NDUFAB1 protects against obesity and insulin resistance by enhancing mitochondrial metabolism. [Journal Article]
    FASEB J 2019; :fj201901117RRZhang R, Hou T, … Wang X
  • Mitochondria are fundamental organelles for cellular and systemic metabolism, and their dysfunction has been implicated in the development of diverse metabolic diseases. Boosted mitochondrial metabolism might be able to protect against metabolic stress and prevent metabolic disorders. Here we show that NADH:ubiquinone oxidoreductase (NDU)-FAB1, also known as mitochondrial acyl carrier protein, ac…
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