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12,371 results
  • Pancreatic cancer organoids recapitulate disease and allow personalized drug screening. [Journal Article]
    Proc Natl Acad Sci U S A 2019Driehuis E, van Hoeck A, … Clevers H
  • We report the derivation of 30 patient-derived organoid lines (PDOs) from tumors arising in the pancreas and distal bile duct. PDOs recapitulate tumor histology and contain genetic alterations typical of pancreatic cancer. In vitro testing of a panel of 76 therapeutic agents revealed sensitivities currently not exploited in the clinic, and underscores the importance of personalized approaches for…
  • Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture. [Journal Article]
    J Vis Exp 2019; (153)Crowell PD, Giafaglione JM, … Goldstein AS
  • The prostate epithelium is comprised predominantly of basal and luminal cells. In vivo lineage tracing has been utilized to define the differentiation capacity of mouse prostate basal and luminal cells during development, tissue-regeneration and transformation. However, evaluating cell-intrinsic and extrinsic regulators of prostate epithelial differentiation capacity using a lineage tracing appro…
  • Precision Health Resource of Control iPSC Lines for Versatile Multilineage Differentiation. [Journal Article]
    Stem Cell Reports 2019Hildebrandt MR, Reuter MS, … Ellis J
  • Induced pluripotent stem cells (iPSC) derived from healthy individuals are important controls for disease-modeling studies. Here we apply precision health to create a high-quality resource of control iPSCs. Footprint-free lines were reprogrammed from four volunteers of the Personal Genome Project Canada (PGPC). Multilineage-directed differentiation efficiently produced functional cortical neurons…
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