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4,628 results
  • Inflammation throughout pregnancy and fetal growth restriction in rural Nepal. [Journal Article]
    Epidemiol Infect 2019; 147:e258Sauder MW, Lee SE, … West KP
  • Maternal systemic inflammation during pregnancy may restrict embryo-fetal growth, but the extent of this effect remains poorly established in undernourished populations. In a cohort of 653 maternal-newborn dyads participating in a multi-armed, micronutrient supplementation trial in southern Nepal, we investigated associations between maternal inflammation, assessed by serum α1-acid glycoprotein a…
  • Urinary orosomucoid: a new marker of cardiovascular risk in psoriatic patients? [Journal Article]
    Ther Clin Risk Manag 2019; 15:831-837Németh B, Péter I, … Ajtay Z
  • CONCLUSIONS: There seems to be a connection between urinary ORM and cardiovascular risk. U-ORM and u-ORM/u-CREAT ratio could be used as an indicator of low-grade inflammation in mild and moderate psoriasis. However, it is the 10-year follow-up of cardiovascular events that will determine the usefulness of this biomarker panel.
  • The bovine acute phase protein α1-acid glycoprotein (AGP) can disrupt Staphylococcus aureus biofilm. [Journal Article]
    Vet Microbiol 2019; 235:93-100Meroni G, Zamarian V, … Ceciliani F
  • Staphylococcus aureus biofilm-related infections are of clinical concern due to the capability of bacterial colonies to adapt to a hostile environment. The present study investigated the capability of the acute phase protein alpha 1-acid glycoprotein (AGP) to a) disrupt already established S. aureus biofilm and b) interfere with the biofilm de novo production by using Microtiter Plate assay (MtP)…
  • The role of ORMDL3/ATF6 in compensated beta cell proliferation during early diabetes. [Journal Article]
    Aging (Albany NY) 2019; 11(9):2787-2796Yang W, Sheng F, … Xiao X
  • Endoplasmic reticulum (ER) stress in beta cells induces a signaling network called the unfolded protein response (UPR), which plays a dual role in diabetes. A key regulator of ER-stress and UPR, the orosomucoid 1-like protein 3 (ORMDL3), has been shown to regulate airway remodeling through a major UPR protein, activating transcription factor 6 (ATF6), but the contribution of this regulatory axis …
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