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637 results
  • Pancreatic lipase inhibitory activity of selected pharmaceutical agents. [Journal Article]
    Acta Pharm 2019; 69(1):1-16Hamdan II, Kasabri VN, … Zalloum H
  • Twenty-five structurally diverse compounds have been tested in vitro for their pancreatic lipase (PL) inhibitory activity. Despite the diversity of tested compounds, the relationship comprising structural attributes of the compounds could be established to correlate with the observed inhibitory activity. Compounds that exerted inhibitory action through surface activity were of different profile f…
  • Chiral Lithium Amido Aryl Zincates: Simple and Efficient Chemo- and Enantio-Selective Aryl Transfer Reagents. [Journal Article]
    Angew Chem Int Ed Engl 2019; 58(10):3193-3197Chaumont-Olive P, Rouen M, … Harrison-Marchand A
  • An enantioselective aryl transfer is promoted using chiral tricoordinated lithium amido aryl zincates that are easily accessible reagents and whose chiral appendage is simply recovered for reuse. The arylation reaction is run in good yields (60 % average on twenty substrates) and high enantiomeric excesses (95 % ee average). This occurs whatever the ortho, meta, or para substituent borne by the s…
  • Inhibition of In Vitro Metabolism of Opioids by Skeletal Muscle Relaxants. [Journal Article]
    Basic Clin Pharmacol Toxicol 2018; 123(3):327-334Moody DE, Fu Y, Fang WB
  • The purpose of this study was to test the hypothesis that skeletal muscle relaxants could inhibit the in vitro metabolism of common comedications opioids buprenorphine, methadone and oxycodone. The compounds [solubility-limited concentration (μM) studied] were as follows: baclofen (1000), carisoprodol (200), its metabolite meprobamate (1000), chlorzoxazone (200), cyclobenzaprine (1000), metaxalon…
  • StatPearls: Antihistamine Toxicity [BOOK]
    StatPearls Publishing: Treasure Island (FL) Borowy Christopher S. CS Midwestern University Mukherji Pinaki P Long Island Jewish Medical Center BOOK
  • In 1943, as the planet was engulfed in WWII and the United States was officially announcing the end of The Great Depression, the most common modern antihistamine, diphenhydramine, was first synthesized. Shortly after in 1947, orphenadrine was synthesized and used for the treatment of Parkinson. With the turn of the decade, antihistamine use became more prevalent, and pediatric deaths increased. A…
  • Anticholinergic medication for antipsychotic-induced tardive dyskinesia. [Review]
    Cochrane Database Syst Rev 2018; 1:CD000204Bergman H, Soares-Weiser K
  • CONCLUSIONS: Based on currently available evidence, no confident statement can be made about the effectiveness of anticholinergics to treat people with antipsychotic-induced tardive dyskinesia. The same applies for the withdrawal of such medications. Whether the withdrawal of anticholinergics may benefit people with antipsychotic-induced TD should be evaluated in a parallel-group, placebo-controlled randomised trial, with adequate sample size and at least 6 weeks of follow-up.
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