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7,584 results
  • Gli1+ Periodontium Stem Cells Are Regulated by Osteocytes and Occlusal Force. [Journal Article]
    Dev Cell. 2020 Jul 08 [Online ahead of print]Men Y, Wang Y, … Zhao H
  • Teeth are attached to alveolar bone by the periodontal ligament (PDL), which contains stem cells supporting tissue turnover. Here, we identified Gli1+ cells in adult mouse molar PDL as multi-potential stem cells (PDLSCs) giving rise to PDL, alveolar bone, and cementum. They support periodontium tissue turnover and injury repair. Gli1+ PDLSCs are surrounding the neurovascular bundle and more enric…
  • StatPearls: Histology, Osteoprogenitor Cells [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Nahian Ahmed A California Baptist University - Lake Erie College of Osteopathic Medicine Davis Donald D. DD Wellstar Atlanta Medical Center BOOK
  • Osteoprogenitor cells, also known as osteogenic cells, are stem cells located in the bone that play a prodigal role in bone repair and growth. These cells are the precursors to the more specialized bone cells (osteocytes and osteoblasts) and reside in the bone marrow. Developed from infant mesenchymal cells, osteoprogenitor cells turn into spindle cells at the surface of matured bones. In develop…
  • StatPearls: Histology, Osteocytes [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Nahian Ahmed A California Baptist University - Lake Erie College of Osteopathic Medicine AlEssa Ahmed M. AM College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia BOOK
  • Osteocytes are one of the four kinds of bone cells. Due to derivation from osteoblasts, these cells are highly specialized in nature and are responsible for the maintenance of the bony matrix. Specially built with innate proteins that help them to survive in hypoxic conditions, osteocytes maintain biomineralization. Not only do osteocytes contribute to bone mass via controlling osteoblast and ost…
  • Bone, a Secondary Growth Site of Breast and Prostate Carcinomas: Role of Osteocytes. [Review]
    Cancers (Basel). 2020 Jul 06; 12(7)Maroni P, Bendinelli P
  • Bone is the primarily preferred site for breast and prostate cancer to metastasize. Bone metastases are responsible for most deaths related to breast and prostate cancer. The bone's particular microenvironment makes it conducive for the growth of cancer cells. Studies on bone metastasis have focused on the interaction between cancer cells and the bone microenvironment. Osteocytes, the most common…
  • CCN1/Cyr61 is required in osteoblasts for responsiveness to the anabolic activity of PTH. [Journal Article]
    J Bone Miner Res. 2020 Jul 07 [Online ahead of print]Zhao G, Kim EW, … Lyons KM
  • CCN1/Cyr61 is a dynamically expressed matricellular protein that serves regulatory functions in multiple tissues. Previous studies from our laboratory demonstrated that CCN1 regulates bone maintenance. Using an osteoblast and osteocyte conditional knockout mouse model (Ccn1OCN ), we found a significant decrease in trabecular and cortical bone mass in vivo, in part through suppression of Wnt signa…
  • Alternative splicing in mesenchymal stem cell differentiation. [Review]
    Stem Cells. 2020 Jul 06 [Online ahead of print]Park JW, Fu S, … Xu RH
  • The differentiation and maturation of mesenchymal stem cells (MSCs) to mesodermal and other lineages are known to be controlled by various extrinsic and intrinsic signals. The dysregulation of the MSC differentiation balance has been linked to several pathophysiological conditions, including obesity and osteoporosis. Previous research of the molecular mechanisms governing MSC differentiation has …
  • A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction. [Journal Article]
    Nat Commun. 2020 Jul 01; 11(1):3282.Sato T, Verma S, … Wein MN
  • Osteocytes, cells ensconced within mineralized bone matrix, are the primary skeletal mechanosensors. Osteocytes sense mechanical cues by changes in fluid flow shear stress (FFSS) across their dendritic projections. Loading-induced reductions of osteocytic Sclerostin (encoded by Sost) expression stimulates new bone formation. However, the molecular steps linking mechanotransduction and Sost suppre…
  • Bioprinting of an osteocyte network for biomimetic mineralization. [Journal Article]
    Biofabrication. 2020 Jul 01 [Online ahead of print]Yang Y, Wang M, … Tang T
  • Osteocytes, essential regulators of bone homeostasis, are embedded in the mineralized bone matrix. Given the spatial arrangement of osteocytes, bioprinting represents an ideal method to biofabricate a 3D osteocyte network with a suitable surrounding matrix similar to native bone tissue. Here, we reported a 3D bioprinted osteocyte-laden hydrogel for biomimetic mineralization in vitro with exceptio…
  • Loss of Sirtuin 6 in osteoblast lineage cells activates osteoclasts, resulting in osteopenia. [Journal Article]
    Bone. 2020 Jun 27; 138:115497.Kim SJ, Piao Y, … Moon SJ
  • Adult bone homeostasis requires a fine-tuned balance between the activity of osteoblasts and osteoclasts. This osteoblast-osteoclast coupling is therapeutically important because it limits the efficacy of most anabolic or anti-resorptive treatments for osteoporosis. Sirtuin6 (SIRT6), a histone deacetylase, was implicated recently as an important regulator in bone homeostasis, but its in vivo func…
  • Local stimulation of osteocytes using a magnetically actuated oscillating beam. [Journal Article]
    PLoS One. 2020; 15(6):e0235366.Onaizah O, Xu L, … Diller E
  • Mechanical loading on bone tissue is an important physiological stimulus that plays a key role in bone growth, fracture repair, and treatment of bone diseases. Osteocytes (bone cells embedded in bone matrix) are well accepted as the sensor cells to mechanical loading and play a critical role in regulating the bone structure in response to mechanical loading. To understand the response of osteocyt…
  • [Research progress on the biological regulatory function of lysophosphatidic acid in bone tissue cells]. [Review]
    Hua Xi Kou Qiang Yi Xue Za Zhi. 2020 Jun 01; 38(3):324-329.Wu XN, Ma YY, … Wang H
  • Lysophosphatidic acid (LPA) is a small phospholipid that is present in all eukaryotic tissues and blood plasma. As an extracellular signaling molecule, LPA mediates many cellular functions by binding to six known G protein-coupled receptors and activating their downstream signaling pathways. These functions indicate that LPA may play important roles in many biological processes that include organ…
  • The Central Role of Osteocytes in the Four Adaptive Pathways of Bone's Mechanostat. [Journal Article]
    Exerc Sport Sci Rev. 2020 Jul; 48(3):140-148.Hughes JM, Castellani CM, … Bouxsein ML
  • We review evidence supporting an updated mechanostat model in bone that highlights the central role of osteocytes within bone's four mechanoadaptive pathways: 1) formation modeling and 2) targeted remodeling, which occur with heightened mechanical loading, 3) resorption modeling, and 4) disuse-mediated remodeling, which occur with disuse. These four pathways regulate whole-bone stiffness in respo…
  • Obtaining Primary Osteocytes through Murine Calvarial Fractionation of GFP-Expressing Osteocytes. [Journal Article]
    J Vis Exp. 2020 Jun 02Marahleh A, Kitaura H, … Mizoguchi I
  • The osteocyte, once thought to be a passive resident of the bone given the backstage function of sensing mechanical loading, is now brought to the spotlight and has been shown to have multiple major functions like actively modifying the extracellular matrix and forming an endocrine organ with the lacunocanalicular system that encloses it sending messages to distant sites. Owing to the methods tha…
  • Mineralized DNA-collagen complex-based biomaterials for bone tissue engineering. [Journal Article]
    Int J Biol Macromol. 2020 Jun 16; 161:1127-1139.James BD, Guerin P, … Allen JB
  • DNA is a highly polyanionic biomolecule that complexes with both collagen and hydroxyapatite. By combining these complexes, we synthesized nucleic-acid collagen complexes (NACC) mineralized with hydroxyapatite. The composite complexes were made using a short, monodisperse single-stranded DNA, type I collagen, and mineralizing medium. They rapidly self-assembled into both mineralized NACC microfib…
  • Experimental Acute Sepsis Reduced Number of Osteocalcin Immunolabeled Cells in Periodontal Ligament. [Journal Article]
    Braz Dent J. 2020 Mar-Apr; 31(2):143-151.Pinheiro GVVDS, Sabino-Silva R, … Claudino M
  • The aim of this study was to evaluate the effect of acute sepsis in the periodontal ligament, alveolar and furcation bone in absence of periodontitis induction through histological and immunohistochemical analyses. A septic rat model was established by cecal ligation and puncture (CLP). Twelve rats were randomly divided into CLP (n=6) and Sham (n=6) groups. The animals were euthanized at 24 h and…
  • Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2. [Journal Article]
    Gene X. 2020 Dec; 5:100027.Galea GL, Paradise CR, … Dudakovic A
  • Mechanical loading-related strains trigger bone formation by osteoblasts while suppressing resorption by osteoclasts, uncoupling the processes of formation and resorption. Osteocytes may orchestrate this process in part by secreting sclerostin (SOST), which inhibits osteoblasts, and expressing receptor activator of nuclear factor-κB ligand (RANKL/TNFSF11) which recruits osteoclasts. Both SOST and…
  • Molecular mechanosensors in osteocytes. [Review]
    Bone Res. 2020; 8:23.Qin L, Liu W, … Xiao G
  • Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of bone remodeling. In addition to their functions in endocrine regulation and calcium and phosphate metabolism, osteocytes are the major responsive cells in force adaptation due to mechanical stimulation. Mechanically induced bone formation and adaptation, disuse-induced bone loss and skeletal fragility are med…
  • Mitochondrial Transcription Factor A added to Osteocytes in a Stressed Environment has a Cytoprotective Effect. [Journal Article]
    Int J Med Sci. 2020; 17(9):1293-1299.Ueda S, Shimasaki M, … Ueda Y
  • The main precipitant of glucocorticoid-associated femoral head osteonecrosis is widely accepted to be an ischemic-hypoxic event, with oxidative stress also as an underlying factor. Mitochondrial DNA is more vulnerable to oxidative injury than the nucleus, and mitochondrial transcription factor A (TFAM), which plays roles in its function, preservation, and regulation is being increasingly investig…
  • The Bone Extracellular Matrix in Bone Formation and Regeneration. [Review]
    Front Pharmacol. 2020; 11:757.Lin X, Patil S, … Qian A
  • Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio-environment with precisely regulated mechanical and biochemical properties. In bone, ECMs are involved in regulating cell adhesion, proliferation, and responses to growth factors, differentiation, and ultimately, the fun…
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