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274,061 results
  • Genomics of gynaecological carcinosarcomas and future treatment options. [Review]
    Semin Cancer Biol 2019Barker HE, Scott CL
  • Gynaecological carcinosarcomas are the most lethal gynaecological malignancies that are often highly resistant to standard chemotherapy. They are composed of both carcinomatous and sarcomatous components and are associated with high rates of metastatic disease. Due to their rarity, molecular studies have been carried out on relatively few tumours, revealing a broad spectrum of heterogeneity. In t…
  • Temporal dynamics of binocular integration in primary visual cortex. [Journal Article]
    J Vis 2019; 19(12):13Cox MA, Dougherty K, … Maier A
  • Whenever we open our eyes, our brain quickly integrates the two eyes' perspectives into a combined view. This process of binocular integration happens so rapidly that even incompatible stimuli are briefly fused before one eye's view is suppressed in favor of the other (binocular rivalry). The neuronal basis for this brief period of fusion during incompatible binocular stimulation is unclear. Neur…
  • Architecture of population-differentiated polymorphisms in the human genome. [Journal Article]
    PLoS One 2019; 14(10):e0224089Bachtiar M, Jin Y, … Lee CGL
  • Population variation in disease and other phenotype are partly attributed to single nucleotide polymorphisms (SNPs) in the human genome. Due to selection pressure, two individuals from the same ancestral population have more genetic similarity compared to individuals from further geographic regions. Here, we elucidated the genomic population differentiation pattern, by interrogating >22,000,000 S…
  • Effect of d-cycloserine on fear extinction training in adults with social anxiety disorder. [Journal Article]
    PLoS One 2019; 14(10):e0223729Hofmann SG, Papini S, … Smits JAJ
  • Preclinical and clinical data have shown that D-cycloserine (DCS), a partial agonist at the N-methyl-d-aspartate receptor complex, augments the retention of fear extinction in animals and the therapeutic learning from exposure therapy in humans. However, studies with non-clinical human samples in de novo fear conditioning paradigms have demonstrated minimal to no benefit of DCS. The aim of this s…
  • Elderly HIV-positive women: A gender-based analysis from the Multicenter Italian "GEPPO" Cohort. [Journal Article]
    PLoS One 2019; 14(10):e0222225Focà E, Magro P, … GEPPO (GEriatric Patients living with HIV/AIDS: a Prospective Multidimensional cOhort) Study Group
  • CONCLUSIONS: Elderly HIV-positive women display a worse virologic response despite a better immune reconstitution compared to males. The burden of comorbidities as well as the medications received (including cART) may slightly differ according to gender. Our data suggest that more efforts and focused interventions are needed in this population.
  • Immune-Inflammation in Atherosclerosis: A New Twist In An Old Tale. [Journal Article]
    Endocr Metab Immune Disord Drug Targets 2019Talepoor AG, Fouladseresht H, … Doroudchi M
  • CONCLUSIONS: Pathogen/oxidative stress/lipid induced primary endothelial wound cannot develop to a full blown atherosclerotic lesion in the absence of chronically induced inflammation. While the primary inflammatory response might be viewed as a lone innate response, the persistence of such a profound response over time must be (and is) associated with diverse local and systemic T cell responses. The interplay between T cells and innate cells contributes to a phenomenon called immune-inflammation and has an impact on the progression and outcome of the lesion. In recent years immune-inflammation, an old term, has had a comeback in connecting the puzzle pieces of chronic inflammatory diseases. Taking one step back and looking from afar at the players of immune-inflammation may help us provide a broader perspective of these complicated interactions. This may lead to identification of new drug targets and development of new therapies as well as preventative measures.
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