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16,992 results
  • [Recent advances in diagnosis and treatment of idiopathic multicentric Castleman disease]. [Journal Article]
    Rinsho Ketsueki 2019; 60(9):1205-1211Okamoto S
  • Multicentric Castleman disease (MCD) is a rare polyclonal lymphoproliferative disease that causes systemic inflammation. In Western countries, human herpesvirus 8 (HHV-8) is frequently associated with MCD pathogenesis, especially in human immunodeficiency virus (HIV)-positive cases, whereas HHV-8 is seldom related to MCD cases in Japan and is referred to as idiopathic MCD (iMCD). iMCD can present…
  • Gastrointestinal Immunity and Alpha-Synuclein. [Journal Article]
    J Parkinsons Dis 2019Barbut D, Stolzenberg E, Zasloff M
  • The gastrointestinal (GI) tract is equipped with robust immune defenses which protect the organism from infection. Enteric nerves are front and center in this defensive network, even in the most primitive organisms. Neuropeptides exhibit potent antimicrobial activity in the vicinity of the nerve and attract the innate and adaptive immune systems to help confine the invading agent. Alpha-synuclein…
  • The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury. [Review]
    Antioxidants (Basel) 2019; 8(10)Kuznetsov AV, Javadov S, … Ausserlechner MJ
  • Mitochondria play a critical role in maintaining cellular function by ATP production. They are also a source of reactive oxygen species (ROS) and proapoptotic factors. The role of mitochondria has been established in many aspects of cell physiology/pathophysiology, including cell signaling. Mitochondria may deteriorate under various pathological conditions, including ischemia-reperfusion (IR) inj…
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