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1,923 results
  • Lack of effect of the combination of metyrapone and oxazepam on brain dopamine. [Journal Article]
    Brain Res 2019; 1724:146435Keller CM, Goeders NE
  • The combination of metyrapone and oxazepam (Met-Ox) has recently shown promise as a pharmacotherapy for cocaine use disorder. Metyrapone is available clinically and is typically used to diagnose adrenal insufficiency, while oxazepam is often prescribed to treat anxiety. The combination of low doses of metyrapone and oxazepam has been shown to significantly attenuate cocaine self-administration an…
  • Benzodiazepines for catatonia in people with schizophrenia or other serious mental illnesses. [Journal Article]
    Cochrane Database Syst Rev 2019; 8:CD006570Zaman H, Gibson RC, Walcott G
  • CONCLUSIONS: Analysis of the results from this review, which was a head-to-head comparison of two benzodiazepine monotherapies, does not show a clear difference in effect. No data were available for benzodiazepines compared to placebo or standard care. The lack of usable data and very low quality of data available makes it impossible to draw firm conclusions and further studies with a high-quality methodology and reporting are required in order to determine more definitively the outcomes associated with benzodiazepine use in the clinical management of catatonia in persons with schizophrenia and other SMI.
  • StatPearls: Oxazepam [BOOK]
    StatPearls Publishing: Treasure Island (FL) Singh Ravneet R Chicago Medical School Rosalind Franklin Abdijadid Sara S BOOK
  • Oxazepam is an FDA-approved benzodiazepine used for the treatment of alcohol withdrawal as well as management of anxiety disorders. Oxazepam has a variety of uses, including several outside of its approved indications such as confusional arousals, sleep terrors, social phobia, PTSD, insomnia, PMDD and catatonia. Currently, oxazepam is not FDA-approved for use in children under the age of six due …
  • Less anxious salmon smolt become easy prey during downstream migration. [Journal Article]
    Sci Total Environ 2019; 687:488-493Klaminder J, Jonsson M, … Hellström G
  • Hatchery-reared salmon smolt used for supplementary stocking often display poor migration behavior compared to wild smolt, which reduces the success of this management action. Oxazepam, an anxiolytic drug, has been shown to intensify salmon smolt migration in mesocosm experiments, and treatment with this drug has, therefore, been suggested as a management option to improve downstream smolt migrat…
  • Tramadol, Methadone and Benzodiazepines added to Alcoholic Beverages. [Journal Article]
    Alcohol Alcohol 2019; 54(4):435-438Ghadirzadeh MR, Nazari SSH, … Fattahi A
  • CONCLUSIONS: The wide availability of addictive pharmaceutical is leading to fortification of alcoholic beverages on some countries. The addition of such depressant additives should be better known because of the potentially fatal consequences of the combination with ethanol, as well as the potential for adverse effects on behavior.
  • A somnolent woman in her fifties with acute circulatory failure. [Journal Article]
    Tidsskr Nor Laegeforen 2019; 139(9)Viland J, Langørgen J, Wendelbo Ø
  • CONCLUSIONS: Flecainide blocks sodium channels in cardiomyocytes. Intoxication with flecainide is rare, with mortality rates of about 10 %. Sodium bicarbonate in larger doses has been reported to stabilise patients with flecainide intoxication due to modification of the binding of flecainide to sodium receptors in cardiomyocytes, and due to alkalisation which makes flecainide detach from sodium receptors. Our patient had a temporary effect with narrowing of QRS complexes after receiving sodium bicarbonate. She also showed a beneficial effect from implantation of a temporary pacemaker, although earlier case reports have described problems with high thresholds and capture failure.
  • Death following consumption of MDAI and 5-EAPB. [Case Reports]
    Forensic Sci Int 2019; 299:89-94Deville M, Dubois N, … Charlier C
  • 5-(2-ethylaminopropyl)benzofuran (5-EAPB) and 5,6-methylenedioxy-2-aminoindane (MDAI) are two new psychoactive substances (NPS) exhibiting MDMA-like properties. In this paper, we report the case of a 28-years old man, known as drug addict, found dead at home, with two unidentified powders next to him. External examination by the forensic pathologist was unremarkable but no autopsy was performed. …
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