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780 results
  • Physiologically based pharmacokinetic modelling of oxycodone drug-drug interactions. [Journal Article]
    Biopharm Drug Dispos 2020Rytkönen J, Ranta VP, … Heikkinen AT
  • Oxycodone is an opioid analgesic with several pharmacologically active metabolites and relatively narrow therapeutic index. Cytochrome P450 (CYP) 3A4 and CYP2D6 play major roles in the metabolism of oxycodone and its metabolites. Thus, inhibition and induction of these enzymes may result in substantial changes in the exposure of both oxycodone and its metabolites. In this study, a physiologically…
  • Comparative Analysis of ELISA Immunoassay and LC-QTOF For Opiate Screening. [Journal Article]
    J Anal Toxicol 2020Kennedy D, Dani M
  • A comparative analysis of enzyme-linked immunosorbent assay (ELISA) and quadropole time-of-flight mass spectrometry (LC-QTOF) for the detection of opioids in blood samples is presented. The Orange County Crime Lab (OCCL) was concerned that the opioid drug class was not accurately detected at low concentrations due to the use of LC-QTOF as a non-targeted screening method for multiple classes of dr…
  • Dynamic changes in prescription opioids from 2006 to 2017 in Texas. [Journal Article]
    PeerJ 2019; 7:e8108Ighodaro EO, McCall KL, … Piper BJ
  • CONCLUSIONS: Collectively, these findings indicate that continued vigilance is needed in Texas to appropriately treat pain and an OUD while minimizing the potential for prescription opioid diversion and misuse. Texas may lead the US in a return to pre-opioid epidemic prescription levels.
  • N-Oxygenation of Oxycodone and Retro-reduction of Oxycodone N-Oxide. [Journal Article]
    Drug Metab Dispos 2020; 48(2):106-115Cashman JR, Gohdes M, … Schoenhard G
  • Oxycodone is used as a potent analgesic medication. Oxycodone is extensively metabolized. To fully describe its metabolism, the oxygenation of oxycodone to oxycodone N-oxide was investigated in hepatic preparations. The hypothesis tested was that oxycodone N-oxygenation was enzymatic and the amount of N-oxide detected was a consequence of both oxygenation and retro-reduction. Methods for testing …
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Hydromorphone [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • Hydromorphone and oxymorphone are semisynthetic derivatives of morphine and potent opiate agonists which are used predominantly to treat moderate-to-severe pain. Neither hydromorphone nor oxymorphone have been linked to serum enzyme elevations during therapy or to clinically apparent liver injury.
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Opioids [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • The opioids are a large class of medications related in structure to the natural plant alkaloids found in opium that are derived from the resin of the opium poppy, Papaver somniferum. The natural alkaloids are also referred to as opiates and include morphine and codeine. Synthetic derivatives include heroin, fentanyl, hydromorphone, methadone, buprenorphine and others. The opioids are highly pote…
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