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109,676 results
  • Effects of gold nanostructures on differentiation of mesenchymal stem cells. [Journal Article]
    Colloids Surf B Biointerfaces 2019; 184:110494Yuan L, Qi X, … Deng J
  • Nanoparticles are nanocrystals with complex facets and defective structures that do not adopt an idealised shape. Various physicochemical parameters of nanoparticles, such as surface composition, size, and stiffness, can regulate differentiation in mesenchymal stem cells (MSCs), but the influence of shapes with many edges and corner regions has not been investigated. Herein, we investigated the e…
  • Anticancer effect of deuterium depleted water - redox disbalance leads to oxidative stress. [Journal Article]
    Mol Cell Proteomics 2019Zhang X, Gaetani M, … Zubarev RA
  • Despite the convincing empirical evidence that deuterium depleted water (DDW, 25-125 ppm deuterium) has anticancer effect, the molecular mechanism remains unclear. Here, redox proteomics investigation of the DDW action in A549 cells revealed an increased level of oxidative stress, while expression proteomics in combination with thermal profiling uncovered crucial role of mitochondrial proteins. I…
  • Impaired function of aorta and perivascular adipose tissue in IL-18-deficient mice. [Journal Article]
    Am J Physiol Heart Circ Physiol 2019Li W, Jin D, … Okamura H
  • Interleukin-18 (IL-18) is ubiquitously produced by both hematopoietic and non-hematopoietic cells, but the central biological role of IL-18 in non-hematopoietic cells has not been sufficiently elucidated. In the present study, we examined the thoracic aorta, including perivascular adipose tissue (PVAT) of the IL-18 knockout (KO) mice in terms of functional and histological aspects. IL-18KO mice e…
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