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499 results
  • Synthesis of a human long-term oxymetholone metabolite. [Journal Article]
    Steroids 2019; 150:108430Kratena N, Biedermann N, … Gärtner P
  • A long-term metabolite of the doping agent oxymetholone (OXM-M2, 17β-hydroxymethyl-2,17α-methyl-18-norandrost-13-en-3-one) which has been identified by GC-MS/MS was synthesized from commercially available materials. Two efficient synthetic routes to access both C-17 epimers of tentative metabolites were developed. The identity and molecular configuration of the in vivo metabolite: 17β-hydroxymeth…
  • Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia? [Review]
    Neurosci Biobehav Rev 2019; 100:180-207Kaufman MJ, Kanayama G, … Pope HG
  • Supraphysiologic-dose anabolic-androgenic steroid (AAS) use is associated with physiologic, cognitive, and brain abnormalities similar to those found in people at risk for developing Alzheimer's Disease and its related dementias (AD/ADRD), which are associated with high brain β-amyloid (Aβ) and hyperphosphorylated tau (tau-P) protein levels. Supraphysiologic-dose AAS induces androgen abnormalitie…
  • Oxymetholone-Induced Acute Renal Failure: A Case Report. [Case Reports]
    Caspian J Intern Med 2018; 9(4):410-412Tarashande Foumani A, Elyasi F
  • CONCLUSIONS: Rhabdomyolysis due to drug use and the consequent acute kidney injury are among the lethal risks associated with anabolic steroid abuse. In most cases, the symptoms are extensive and often misleading. Therefore, detailed history taking, physical scrutiny, paraclinical testing, and early diagnosis are crucial for rhabdomyolysis patients.
  • 1H NMR determination of adulteration of anabolic steroids in seized drugs. [Journal Article]
    Steroids 2018; 138:47-56Ribeiro MVM, Boralle N, … Pezza L
  • Counterfeiting and adulteration of pharmaceuticals is a prevalent problem worldwide and represents a major health risk to the population, with anabolic steroids being one of the main classes of drugs consumed and obtained from dubious sources. In this work, we propose the use of the 1H NMR technique to evaluate formulations containing anabolic steroids, with analysis of 40 samples of anabolic dru…
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