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136 results
  • DNA damage in cells exhibiting radiation-induced genomic instability. [Journal Article]
    Mutagenesis 2015; 30(3):451-8Keszenman DJ, Kolodiuk L, Baulch JE
  • Cells exhibiting radiation-induced genomic instability exhibit varied spectra of genetic and chromosomal aberrations. Even so, oxidative stress remains a common theme in the initiation and/or perpetuation of this phenomenon. Isolated oxidatively modified bases, abasic sites, DNA single strand breaks and clustered DNA damage are induced in normal mammalian cultured cells and tissues due to endogen…
  • Uridine--an indicator of post-exercise uric acid concentration and blood pressure. [Journal Article]
    Physiol Res 2015; 64(4):467-77Dudzinska W, Lubkowska A, … Janiak M
  • Studies have shown that uridine concentration in plasma may be an indicator of uric acid production in patients with gout. It has been also postulated that uridine takes part in blood pressure regulation. Since physical exercise is an effective tool in treatment and prevention of cardio-vascular diseases that are often accompanied by hyperuricemia and hypertension, it seemed advisable to attempt …
  • GeneReviews®: Lesch-Nyhan Syndrome [BOOK]
    University of Washington, Seattle: Seattle (WA)Adam MP, Ardinger HH, … Amemiya ANyhan WL, O'Neill JP, … Harris JCBOOK
  • Lesch-Nyhan syndrome is characterized by motor dysfunction that resembles cerebral palsy, cognitive and behavioral disturbances, and uric acid overproduction (hyperuricemia). The most common presenting features, hypotonia and developmental delay, are evident by age three to six months. Affected children are delayed in sitting and most never walk. Within the first few years, extrapyramidal involve…
  • Enzymatic properties and physiological roles of cytosolic 5'-nucleotidase II. [Review]
    Curr Med Chem 2013; 20(34):4260-84Itoh R
  • Cytosolic 5'-nucleotidase II (cN-II) is an intracellular 5'-nucleotidase characterized by substrate specificity. It preferentially hydrolyzes 6-hydroxypurine nucleotides such as IMP and GMP over AMP or UMP. cN-II is allosterically activated by ATP and inhibited by inorganic phosphate. It also has phosphotransferase activity and transfers phosphate moieties from IMP or GMP to nonphysiological nucl…
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