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27,864 results
  • Implication of in vivo circulating fibrocytes ablation in experimental pulmonary hypertension murine model. [Journal Article]
    Br J Pharmacol 2020Nikam VS, Nikam S, … Voswinckel R
  • CONCLUSIONS: Our data demonstrate that circulating fibrocytes ablation has a potential impact on right ventricular hypertrophy and vascular remodelling in the setting of experimental PH induced by hypoxia. The beneficial effects may be related to the direct contribution of fibrocytes or its paracrine effect on other resident cell types. Thus, clinical manipulation of circulating fibrocytes may represent a novel therapeutic approach to ameliorate disease state in PH.
  • Discrete Hedgehog Factor Expression and Action in the Developing Phallus. [Journal Article]
    Int J Mol Sci 2020; 21(4)Tarulli GA, Pask AJ, Renfree MB
  • Hypospadias is a failure of urethral closure within the penis occurring in 1 in 125 boys at birth and is increasing in frequency. While paracrine hedgehog signalling is implicated in the process of urethral closure, how these factors act on a tissue level to execute closure itself is unknown. This study aimed to understand the role of different hedgehog signalling members in urethral closure. The…
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