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110,395 results
  • Concurrent sodium channelopathies and amyotrophic lateral sclerosis supports shared pathogenesis. [Journal Article]
    Amyotroph Lateral Scler Frontotemporal Degener. 2020 Jul 03 [Online ahead of print]Franklin JP, Cooper-Knock J, … Hanna MG
  • Amyotrophic lateral sclerosis (ALS) is an invariably fatal adult-onset neurodegenerative disorder; approximately 10% of ALS is monogenic but all ALS exhibits significant heritability. The skeletal muscle sodium channelopathies are a group of inherited, non-dystrophic ion channel disorders caused by heterozygous point mutations in the SCN4A gene, leading to clinical manifestations of congenital my…
  • Sustained Immunoparalysis in Endotoxin-Tolerized Monocytic Cells. [Journal Article]
    Mediators Inflamm. 2020; 2020:8294342.Weisheit CK, Klüners A, … Ehrentraut H
  • Sepsis is associated with a strong inflammatory reaction triggering a complex and prolonged immune response. Septic patients have been shown to develop sustained immunosuppression due to a reduced responsiveness of leukocytes to pathogens. Changes in cellular metabolism of leukocytes have been linked to this phenomenon and contribute to the ongoing immunological derangement. However, the underlyi…
  • Intraoperative Neuromonitoring in Thyroid and Parathyroid Surgery. [Journal Article]
    J Laparoendosc Adv Surg Tech A. 2020 Jul 01 [Online ahead of print]Zhu Y, Gao DS, … Yu L
  • Background: It has been reported that the incidence of recurrent laryngeal nerve (RLN) injury is higher in an operational procedure in the thyroid and parathyroid region. Elevating voice pitch is achieved by the cricothyroid contraction, which in turn is innervated by the external branch of the superior laryngeal nerve (EBSLN). Due to the subtle nature…
  • Computational Identification of Kinases That Control Axon Growth in Mouse. [Journal Article]
    SLAS Discov. 2020 Jul 02 [Online ahead of print]Devkota P, Danzi MC, … Wuchty S
  • The determination of signaling pathways and transcriptional networks that control various biological processes is a major challenge from both basic science and translational medicine perspectives. Because such analysis can point to critical disease driver nodes to target for therapeutic purposes, we combined data from phenotypic screening experiments and gene expression studies of mouse neurons t…
  • Pneumococcal Meningitis Complicated by Spinal Cord Dysfunction and Acute Polyradiculopathy. [Case Reports]
    Ochsner J. 2020 Summer; 20(2):219-221.Abdallah MA, Ahmed KM, … Khalid M
  • Background: Meningitis caused by Streptococcus pneumoniae is associated with devastating clinical outcomes. A considerable number of patients will develop long-term neurologic complications. Hearing loss, diffuse brain edema, and hydrocephalus are frequently encountered. Acute spinal cord dysfunction and polyradiculopathy can develop in some patients. Case Report: A 63-year-old female was admitt…
  • Estimation of Subglottal Pressure From Neck Surface Vibration in Patients With Voice Disorders. [Journal Article]
    J Speech Lang Hear Res. 2020 Jul 01 [Online ahead of print]Marks KL, Lin JZ, … Mehta DD
  • Purpose Given the established linear relationship between neck surface vibration magnitude and mean subglottal pressure (Ps) in vocally healthy speakers, the purpose of this study was to better understand the impact of the presence of a voice disorder on this baseline relationship. Method Data were obtained from participants with voice disorders representing a variety of glottal conditions, inclu…
  • Binding of a viral IRES to the 40S subunit occurs in two successive steps mediated by eS25. [Journal Article]
    Nucleic Acids Res. 2020 Jul 01 [Online ahead of print]Walters B, Axhemi A, … Thompson SR
  • The mechanism for how internal ribosome entry sites (IRESs) recruit ribosomes to initiate translation of an mRNA is not completely understood. We investigated how a 40S subunit was recruited by the cricket paralysis virus intergenic region (CrPV IGR) IRES to form a stable 40S-IRES complex. Kinetic binding studies revealed that formation of the complex between the CrPV IGR and the 40S subunit cons…
  • A systematic review of impairment focussed technology in neurology. [Journal Article]
    Disabil Rehabil Assist Technol. 2020 Jul 01 [Online ahead of print]Waerling RD, Kjaer TW
  • Objective: We provide an overview of some biomedical technologies able to relieve everyday impairments in neurological patients.Methods: Two literature searches from 2009 to 2020 were conducted using PubMed, Embase, Cinahl and Scopus. The studies meeting the criteria for eligibility constituted 224 of the 6257 identified studies.Results: The first literature search resulted in the identificati…
  • Assessment of diaphragmatic function by ultrasonography: Current approach and perspectives. [Review]
    World J Clin Cases. 2020 Jun 26; 8(12):2408-2424.Boussuges A, Rives S, … Brégeon F
  • This article reports the various methods used to assess diaphragmatic function by ultrasonography. The excursions of the two hemidiaphragms can be measured using two-dimensional or M-mode ultrasonography, during respiratory maneuvers such as quiet breathing, voluntary sniffing and deep inspiration. On the zone of apposition to the rib cage for both hemidiaphragms, it is possible to measure the th…
  • Bilateral acute anterior uveitis and iris atrophy caused by moxifloxacin. [Journal Article]
    BMJ Case Rep. 2020 Jun 30; 13(6)Hui BTK, Capewell N, … Liu X
  • A 56-year-old paramedic was admitted to hospital and treated for severe pneumonia. Shortly after initiating antibiotic treatment (including moxifloxacin), he developed bilaterally painful eyes and was diagnosed with bilateral acute anterior uveitis (AAU). Three years later, he was referred to the ophthalmology clinic with bilateral iris transillumination suggesting iris atrophy and limited pupill…
  • Two trajectories of functional recovery in thyroid surgery-related unilateral vocal fold paralysis. [Journal Article]
    Surgery. 2020 Jun 27 [Online ahead of print]Pei YC, Lu YA, … Fang TJ
  • CONCLUSIONS: Among patients with thyroid surgery-related unilateral vocal fold paralysis, superior laryngeal nerve injury induces a distinctively different recovery trajectory compared with those without superior laryngeal nerve injury characterized by less reinnervation of vocal fold adductors and worse presentation in terms of the glottal gap and maximum phonation time. This study emphasizes the importance of superior laryngeal nerve function and its preservation in thyroid surgery.
  • A Review of Methods for the Preservation of Laryngeal Nerves During Thyroidectomy. [Review]
    Sisli Etfal Hastan Tip Bul. 2018; 52(2):79-91.Uludağ M, Tanal M, İşgör A
  • The recurrent laryngeal nerve (RLN) provides motor innervation to the abductor and adductor muscles of the vocal cord, whereas the external branch of the superior laryngeal nerve (EBSLN) provides motor innervation to the cricothyroid muscle, which is the tensor muscle of the vocal cord. Both the RLN and the EBSLN are anatomically close to the thyroid and are therefore at risk of injury during thy…
  • Complication Risk in Secondary Thyroid Surgery. [Journal Article]
    Sisli Etfal Hastan Tip Bul. 2018; 52(1):19-25.Aygün N, Besler E, … Uludağ M
  • CONCLUSIONS: When performed with a meticulous and attentive technique, secondary surgical intervention can be applied without increasing the incidence of permanent complications. Though there is substantial risk associated with all of these procedures, the rate of vocal cord paralysis was similar to that seen after primary intervention, and was thought to be related to surgical experience and technique, as well as the use of IONM.
  • ACOD1 in immunometabolism and disease. [Review]
    Cell Mol Immunol. 2020 Jun 29 [Online ahead of print]Wu R, Chen F, … Kang R
  • Immunometabolism plays a fundamental role in health and diseases and involves multiple genes and signals. Aconitate decarboxylase 1 (ACOD1; also known as IRG1) is emerging as a regulator of immunometabolism in inflammation and infection. Upregulation of ACOD1 expression occurs in activated immune cells (e.g., macrophages and monocytes) in response to pathogen infection (e.g., bacteria and viruses…
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