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106,645 results
  • Engineering Surface Patterning of Colloidal Rings through Plateau-Rayleigh Instability. [Journal Article]
    Angew Chem Int Ed Engl 2019Liu B, Luo Z, Zhou J
  • We report Plateau-Rayleigh (P-R) instability occurring on Brownian colloidal particles and demonstrate that this instability can be used for the surface patterning of Brownian colloidal rings. This idea was realized by employing polystyrene(PS)/SiO2 core/shell rings, for which PS layer was selectively grown onto the interior surface of SiO2 rings. The P-R instability was initiated in the ring's d…
  • Dynamic postnatal development of the cellular and circuit properties of striatal D1 and D2 spiny projection neurons. [Journal Article]
    J Physiol 2019Krajeski RN, Macey-Dare A, … Ellender TJ
  • CONCLUSIONS: Imbalances in the activity of the D1-expressing direct-pathway and D2-expressing indirect-pathway striatal projection neurons (SPNs) are thought to contribute to many basal ganglia disorders, including early-onset neurodevelopmental disorders such as OCD, ADHD and Tourette's syndrome. This study provides the first detailed quantitative investigation of D1 and D2 SPN development, including their cellular properties and connectivity within neural circuits, during the first postnatal weeks. This period is highly dynamic with many properties changing, but it is possible to make three main observations. Firstly, that many aspects of D1 and D2 SPNs progressively mature in parallel. Secondly, that there are notable exceptions when they diverge. Thirdly, that many of the defining properties of mature striatal SPNs and circuits are already established by the first and second postnatal weeks, suggesting guidance through intrinsic developmental programs. These findings provide an experimental framework for future studies of striatal development in both health and disease.
  • A ten-year retrospective study of post-dural puncture headache in 32,655 obstetric patients. [Journal Article]
    Can J Anaesth 2019Costa AC, Satalich JR, … Bennett-Guerrero E
  • CONCLUSIONS: We showed a relatively low incidence (< 1%) of post-dural puncture headache following neuraxial anesthesia in parturients at an academic tertiary-care medical centre. Patients that rated their post-dural puncture headache as very severe were more likely to undergo at least one epidural blood patch procedure. Post-dural puncture headache is a well-known complication of neuraxial anesthesia, and may lead to a delay in hospital discharge.
  • Structural Basis for the Selective Inhibition of Cdc2-Like Kinases by CX-4945. [Journal Article]
    Biomed Res Int 2019; 2019:6125068Lee JY, Yun JS, … Chang JH
  • Cdc2-like kinases (CLKs) play a crucial role in the alternative splicing of eukaryotic pre-mRNAs through the phosphorylation of serine/arginine-rich proteins (SR proteins). Dysregulation of this processes is linked with various diseases including cancers, neurodegenerative diseases, and many genetic diseases. Thus, CLKs have been regarded to have a potential as a therapeutic target and significan…
  • Safe Discharge of Patients From an Ambulatory Care Center After Incidental Durotomy During Minimally Invasive Spine Surgery. [Journal Article]
    Int J Spine Surg 2019; 13(4):386-391Francavilla TL, Weiss MC, Davis R
  • CONCLUSIONS: Incidental durotomy occurring during minimally invasive spinal decompressive surgery is an occasional event. Suture repair of the laceration is feasible in most instances. Lumbar spine patients may be safely discharged to home from the ASC. Patients can be stratified into those with, or without, a watertight suture dural closure. Those with such a closure, who are without symptoms of intracranial hypotension, do not require modification of their activities. A short period of bedrest with head of bed modification successfully treated the remainder. Hospitalization or routine prolonged bed rest is not necessary. Protocols must be put in place to identify and timely manage potentially serious sequelae.
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