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183,047 results
  • Tuberculosis control in crisis-causes and solutions. [Review]
    Prog Biophys Mol Biol 2019Kaplan G
  • Tuberculosis incidence is projected to decline at too slow a rate to meet the targets set at the UN high level meeting on ending tuberculosis, convened in New York in 2018. To understand the causes of the slow progress in tuberculosis control, the Bill and Melinda Gates Foundation supported a patient-pathway analysis that identified significant gaps with patients being "lost" at all points along …
  • Filament-like Assemblies of Intracellular Nucleic Acid Sensors: Commonalities and Differences. [Review]
    Mol Cell 2019; 76(2):243-254Cadena C, Hur S
  • Self versus non-self discrimination by innate immune sensors is critical for mounting effective immune responses against pathogens while avoiding harmful auto-inflammatory reactions against the host. Foreign DNA and RNA sensors must discriminate between self versus non-self nucleic acids, despite their shared building blocks and similar physicochemical properties. Recent structural and biochemica…
  • Norovirus Activity and Genotypes in Sporadic Acute Diarrhea in Children in Shanghai During 2014-2018. [Journal Article]
    Pediatr Infect Dis J 2019; 38(11):1085-1089Wang X, Wei Z, … Zeng M
  • CONCLUSIONS: Norovirus is a major pathogen causing diarrhea in Shanghainese children. GII.Pe/GII.4-Sydney/2012 strains remained the predominant genotype. The emergence of GII.P17/GII.17 and GII.P16/GII.2 strains in sporadic diarrhea was consistent with norovirus-associated outbreaks attributable to these 2 novel variants in China. Continuous monitoring norovirus genotypes circulating in pediatric population is needed for current vaccine development.
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