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(pathogen associated molecular patterns)
4,292 results
  • Bioassay for Endothelial Damage Mediators Retrieved by Hemoadsorption. [Journal Article]
    Sci Rep 2019; 9(1):14522Denzinger M, Staendker L, … Schneider EM
  • Hemoadsorption devices are used to treat septic shock by adsorbing inflammatory cytokines and as yet incompletely defined danger and pathogen associated molecular patterns. In an ideal case, hemoadsorption results in immediate recovery of microvascular endothelial cells' (mEC) function and rapid recovery from catecholamine-dependency and septic shock. We here tested a single device, which consist…
  • Recent Insights on Inflammasomes, Gasdermin Pores, and Pyroptosis. [Journal Article]
    Cold Spring Harb Perspect Biol 2019de Vasconcelos NM, Lamkanfi M
  • Inflammasomes assemble in the cytosol of myeloid and epithelial cells on sensing of cellular stress and pathogen-associated molecular patterns and serve as scaffolds for recruitment and activation of inflammatory caspases. Inflammasomes play beneficial roles in host and immune responses against diverse pathogens but may also promote inflammatory tissue damage if uncontrolled. Gasdermin D (GSDMD) …
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