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(pathogen associated molecular patterns)
4,195 results
  • CD14: Biology and role in the pathogenesis of disease. [Review]
  • CGCytokine Growth Factor Rev 2019 Jul 03
  • Wu Z, Zhang Z, … Lei P
  • Human monocyte differentiation antigen CD14 is a pattern recognition receptor (PRR) that enhances innate immune responses. CD14 was first identified as a marker of monocytes to signal intracellular r…
  • Broad-spectrum capture of clinical pathogens using engineered Fc-mannose-binding lectin enhanced by antibiotic treatment. [Journal Article]
  • FF1000Res 2019; 8:108
  • Seiler BT, Cartwright M, … Ingber DE
  • CONCLUSIONS: The efficiency of pathogen detection and variation between binding of different strains of the same species could be improved by treating the bacteria with antibiotics, or mechanical disruption using a bead mill, prior to FcMBL capture to reveal previously concealed binding sites within the bacterial cell wall. As FcMBL can bind to pathogens and PAMPs in urine as well as blood, its broad-binding capability could be leveraged to develop a variety of clinically relevant technologies, including infectious disease diagnostics, therapeutics, and vaccines.
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