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807,068 results
  • StatPearls: Fenofibrate [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Sidhu Gursharan G Avalon University School of Medicine Tripp Jayson J CUSOM/Cape Fear Valley Health Center BOOK
  • Fenofibrate is FDA approved for the management and treatment of hypertriglyceridemia, primary hypercholesterolemia or mixed dyslipidemia. It reduces low-density lipoprotein, triglycerides, and total cholesterol while increasing high-density lipoprotein cholesterol in adults. Fenofibrate should be used in conjunction with a restriction of cholesterol intake and exercise if lifestyle modifications …
  • StatPearls: Pediatric Preoperative Management [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Ahmed Zulfiqar Z Wayne St. University School of Medicine Rufo Paul A. PA Harvard University/Boston Children's Hospital BOOK
  • The preoperative management of anesthesia in children differs from that employed in adults, including employing age-group appropriate language, understanding the dynamics of the child's family, and assessing the patient's developmental stage. Children are not small adults. Hence, we must have an understanding of the variability of each child's age and family-specific needs in an effort to develop…
  • StatPearls: Radial Neck Fracture Repair In A Child [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Khajuria Apoorva A University Hospitals Coventry & Warwickshire M Das Joe J National Hospital for Neurology and Neurosurgery, Queen Square, London BOOK
  • Radial neck fractures commonly occur in children and tend to be more prevalent at ages 9 to 10 years; they represent up to 10% of all pediatric elbow fractures. The mechanism of injury is usually a fall on an outstretched hand with a valgus compressive force across the elbow joint. The initial assessment should include an examination of the elbow joint, followed by plain radiographs of the elbow.…
  • StatPearls: Avulsion Fractures [BOOK]
    . StatPearls Publishing: Treasure Island (FL) McCoy Jordan S. JS Michigan State University- Ascension Genesys Hospital Nelson Ryan R Michigan State University, Ascension Genesys BOOK
  • An avulsion fracture is a failure of bone in which a bone fragment is pulled away from its main body by soft tissue that is attached to it.[1][2] Avulsion fractures can occur in any area where soft tissue is attached to bone. The failure of bone most commonly results from an acute event with the application of usually sudden, tensile force to the bone through the soft tissue, or when chronic repe…
  • StatPearls: Posttraumatic Stress Disorder In Children [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Fariba Kamron K University Hospital Gupta Vikas V South Carolina Department of Mental Health BOOK
  • Posttraumatic stress disorder (PTSD) is a mental disorder that may develop in some children and adolescents after exposure to a traumatic event. Traumatic events may include incidents that involve serious harm to self or others and include accidents, natural disasters, sexual or physical trauma, natural disasters, and violence.[1] Since time immemorial, scientists have pursued the ever-elusive ca…
  • StatPearls: Valproic Acid (Divalproex Sodium) [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Rahman Masum M Mayo Clinic Nguyen Hoang H NOVA Southeastern University BOOK
  • Valproic acid is a branched, and short-chain fatty acid is a derivative of naturally occurring valeric acid. Valproic acid's primary use is as an anti-seizure medication, as well as in migraine, bipolar, mood, and anxiety disorders. Recent work has also demonstrated its efficacy as adjuvant therapy in HIV, cancer, and neurodegenerative diseases as its histone deacetylase (HDAC) inhibition propert…
  • StatPearls: Past Present and Future of Simulation in Pediatrics [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Davila Ulysses U Medical University of South Carolina Price Amanda A Medical University South Carolina BOOK
  • The development of simulation has been evolving in technology and utilization over the last several centuries, with the increased application over the past 2 to 3 decades in the field of pediatrics. Today, simulation-based medical education (SBME) is widely used by a majority of pediatric training programs and is marked by a large variety of technologies and continued interest and availability of…
  • StatPearls: Beckwith Wiedemann Syndrome [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Borjas Mendoza Paulo A. PA Lincoln Medical and Mental Health Center Mendez Magda D. MD Lincoln Medical Center/Weil Cornell BOOK
  • Beckwith-Wiedemann Syndrome (BWS) is the most common overgrowth syndrome. The condition was named after American pediatric pathologist John Bruce Beckwith in 1963, and German pediatrician Hans-Rudolf Wiedemann in 1964, reported the syndrome independently.[1] Etiologically, BWS is a human imprinting disorder caused by genetic and epigenetic changes affecting the regulation of genes on chromosome 1…
  • StatPearls: Ethacrynic Acid [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Aribo Chade C UC Riverside Ng Daniel K. DK University of California Riverside BOOK
  • Ethacrynic acid is a loop diuretic that gained FDA approval for widespread use in 1967. Unlike other loop diuretics, ethacrynic acid is a novel drug due to the absence of a sulfonamide group in its structure, allowing its use in critically ill patients with life-threatening sulfa-allergies.[1] In adults, ethacrynic acid is a choice for the relief of edema in patients with renal failure, congestiv…
  • StatPearls: Post Intensive Care Syndrome (PICS) [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Smith Sarah S Westchester Medical Center Rahman Omar O Indiana Univeristy Health BOOK
  • While the short-term outcomes of ICU patients have dramatically improved over the last half-century, it is increasingly recognized that many ICU survivors experience declines in physical and cognitive functioning that persist well beyond their acute hospitalization. Psychiatric sequelae, including anxiety, depression, and post-traumatic stress disorder (PTSD) are also prevalent among both ICU sur…
  • StatPearls: Fontan Completion [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Lee Madonna M Seattle Children’s Shahjehan Rai Dilawar RD Conemaugh Memorial Medical Center BOOK
  • The Fontan procedure provides a palliative treatment option for pediatric patients with functionally single ventricle congenital heart disease, with an estimated incidence of 0.08 to 0.4 per 1,000 live births.[1] Total right heart bypass was described in 1971[2] for tricuspid atresia with the Fontan procedure, or the total cavopulmonary connection (TCPC) procedure. There is a relatively recent hi…
  • StatPearls: Pediatric Facial Trauma [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Rogan Daniel T. DT Stanford University Healthcare Fang Andrea A BOOK
  • Trauma is the leading cause of injury and death in the pediatric population.[1] Head trauma is the most common form of pediatric trauma, though reassuringly maxillofacial trauma is less common.[2] Facial trauma ranges from soft tissue, bony, and neurovascular injuries that can be due to any trauma, affecting the face, including the eyes, nose, mouth, bones, and skin. In infants and younger pediat…
  • StatPearls: Sandifer Syndrome [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Patil Sowmya S University Of Arkansas for Medical Sciences, Arkansas Childrens Hospital Tas Vildan V University of Arkansas for Medical Sciences BOOK
  • Sandifer syndrome (SS) is a type of movement disorder that constitutes paroxysmal spasms of head, neck, and back arching but spares the limbs. SS is often associated with gastroesophageal reflux (GERD) in children. Due to the abnormal posturing, parents may describe the dystonic episodes of SS as possible seizures. Therefore this causes great concern among parents and poses a diagnostic dilemma t…
  • Maternal Outcomes of Ongoing Pregnancies Complicated by Fetal Life-Limiting Conditions. [Journal Article]
    Am J Perinatol. 2020 Jul 09 [Online ahead of print]Coney T, Russell R, … Palatnik A
  • CONCLUSIONS:  After controlling for confounding factors, except a longer first stage of labor, women diagnosed with fetal life-limiting conditions who continued the pregnancy did not have a higher rate of adverse maternal outcomes.· The rates of ongoing pregnancies with fetal life-limiting conditions are increasing.. · Women with ongoing pregnancies with fetal life-limiting conditions had longer first stage of labor.. · The rest of the adverse maternal outcomes were not increased in this obstetric population..
  • Circular RNA circMBOAT2 promotes prostate cancer progression via a miR-1271-5p/mTOR axis. [Journal Article]
    Aging (Albany NY). 2020 Jul 09; 12Shi J, Liu C, … Xu K
  • Patients with advanced prostate cancer (PCa) have poor prognosis. Circular RNAs (circRNAs) regulate biological processes in a variety of cancers, but the precise roles of circRNAs in PCa are poorly understood. Herein, we identified a novel circRNA, termed circMBOAT2 (has_circ_0007334), which was significantly overexpressed in PCa tissues and cell lines. Overexpression of circMBOAT2 was associated…
  • Is the presence of lung injury in COVID-19 an independent risk factor for secondary lung cancer? [Journal Article]
    Med Hypotheses. 2020 Jul 03; 143:110074.Tao SL, Wang XM, … Deng B
  • The morbidity and mortality of lung cancer are increasing. The Corona Virus Disease 2019 (COVID-19) is caused by novel coronavirus 2019-nCoV-2, leading to subsequent pulmonary interstitial fibrosis with chronic inflammatory changes, e.g., inflammatory factors repeatedly continuously stimulating and attacking the alveolar epithelial cells. Meanwhile, 2019-nCoV-2 can activate PI3K/Akt and ERK signa…
  • Bridging the healthcare gap: Building the case for epilepsy virtual clinics in the current healthcare environment. [Review]
    Epilepsy Behav. 2020 Jul 06; 111:107262.Lavin B, Dormond C, … Brodie MJ
  • Access to quality healthcare remains a challenge that is complicated by mounting pressures to control costs, and now, as we witness, the unprecedented strain placed on our healthcare delivery systems due to the COVID-19 pandemic. Challenges in healthcare access have driven a need for innovative approaches ensuring connectivity to health providers. Telehealth services and virtual clinics offer acc…
  • Identification of novel loss of function variants in MBOAT7 resulting in intellectual disability. [Journal Article]
    Genomics. 2020 Jul 06 [Online ahead of print]Heidari E, Caddeo A, … Garshasbi M
  • The membrane bound O-acyltransferase domain-containing 7 (MBOAT7) gene codes for an enzyme involved in regulating arachidonic acid incorporation in lysophosphatidylinositol. Patients with homozygous nonsense mutations in MBOAT7 have intellectual disability (ID) accompanied with seizure and autism. Accumulating evidences obtained from human genetic studies have shown that MBOAT7 is also involved i…
  • Identifying early abdominal obesity risk in adolescents by telemedicine: a cross-sectional study in Greece. [Journal Article]
    Food Chem Toxicol. 2020 Jul 06 [Online ahead of print]Bacopoulou F, Landis GN, … Efthymiou V
  • Obesity and thus, lipotoxicity, is a major health risk factor. Modern exposure to environmental chemicals has contributed significantly to the obesity epidemic. The purpose of this study was to assess, via telemedicine and using bioelectrical impedance analysis (BIA) in schools, the levels of adiposity and other body composition parameters of Greek adolescents in relation with their metabolic syn…
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