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(penicilloyl polylysine)
92 results
  • Evaluating Penicillin Allergies Without Skin Testing. [Review]
    Curr Allergy Asthma Rep 2019; 19(5):27Banks TA, Tucker M, Macy E
  • An unconfirmed penicillin allergy is known to confer significant risk to patients. Only a small minority of patients labeled with penicillin allergy will be confirmed to be hypersensitive with the current reference standard test, an oral amoxicillin therapeutic dose challenge. Skin testing has been recommended prior to oral challenges to reduce the risk of severe acute challenge reactions. The ra…
  • Penicillin minor determinants: History and relevance for current diagnosis. [Review]
    Ann Allergy Asthma Immunol 2018; 121(5):537-544Adkinson NF, Mendelson LM, … Keogh JC
  • CONCLUSIONS: IgE skin testing, using both the major and appropriate minor determinants of penicillin, can identify, with a high degree of reliability (NPV ∼97%), penicillin allergy history-positive patients who can receive beta-lactam antibiotics without concern for serious acute allergy, including anaphylaxis. The few false-negative skin tests reported globally are largely confined to minor, self-limited cutaneous reactions.
  • A Proactive Approach to Penicillin Allergy Testing in Hospitalized Patients. [Journal Article]
    J Allergy Clin Immunol Pract 2017 May - Jun; 5(3):686-693Chen JR, Tarver SA, … Khan DA
  • CONCLUSIONS: Penicillin allergy testing using a physician-pharmacist team model effectively removes reported allergies in hospitalized patients. The electronic medical record is a valuable asset for locating and stratifying individuals who benefit most from intervention. Proactive testing substantially reduces unnecessary inpatient and outpatient use of beta-lactam alternatives that may otherwise go unaddressed.
  • Skin testing with β-lactam antibiotics for diagnosis of β-lactam hypersensitivity in children. [Clinical Trial]
    Asian Pac J Allergy Immunol 2016; 34(3):242-247Manuyakorn W, Singvijarn P, … Jotikasthira W
  • CONCLUSIONS: Among those children with a history of β-lactam hypersensitivity, skin testing with penicillin G, ampicillin, amoxicillin-clavulanic acid, and the suspect β-lactam was safe and provided a good NPV when PPL and MDM were unavailable. However, a skin test with β-lactam antibiotics alone did not provide a high sensitivity, thus a DPT procedure was necessary in order to confirm the diagnosis of β-lactam hypersensitivity.
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