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408 results
  • Peramivir for Influenza A and B Viral Infections: A Pharmacokinetic Case Series. [Journal Article]
    Pharmacotherapy 2019Cies JJ, Moore WS, … Chopra A
  • CONCLUSIONS: The pharmacokinetics of PRV demonstrated in this PICU cohort differs in comparison to healthy pediatric and adult patients, and alterations to dosing regimens may be needed in PICU patients to achieve pharmacodynamic exposures. Additional investigations in the PICU population are needed to confirm these findings.
  • Novel amides modified rupestonic acid derivatives as anti-influenza virus reagents. [Journal Article]
    Bioorg Med Chem Lett 2019; 29(19):126605Li G, Obul M, … Aisa HA
  • In spired by the important role of amide groups of anti-influenza drugs oseltamivir, zanamivir and peramivir in bioactivity, a series of novel amides modified rupestonic acid derivatives were designed and synthesized. The absolute configuration of critical intermediate bearing chloride with newly formed stereocenter was confirmed by X-ray crystallographic analysis. And all new compounds were eval…
  • Potential Role of Endonuclease Inhibition and Other Targets in the Treatment of Influenza. [Journal Article]
    Curr Drug Targets 2019Szollosi DE, Bill A
  • CONCLUSIONS: Due to the possibility of viral mutations and resistance, it is important to have antivirals with different mechanisms available, especially in the case of a new pandemic strain. Several novel antivirals are within various stages of development and may represent new classes of treatments that can reduce symptoms and complications in those patients who may be at higher risk.
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