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80,082 results
  • Dispersal and Inhibition of Biofilms Associated with Infections. [Review]
    J Appl Microbiol 2019Yan Z, Huang M, … Kjellerup BV
  • As bacteria aggregate and form biofilms on surfaces in the human body such as tissues, indwelling medical devices, dressings, and implants, they can cause a significant health risk. Bacterial biofilms possess altered phenotypes: physical features that facilitate antibiotic resistance and evasion of the host immune response. Since metabolic and physical factors contribute to biofilm maturation and…
  • The future of microbiome-based therapeutics in clinical applications. [Review]
    Clin Pharmacol Ther 2019Sharma A, Das P, … Gilbert JA
  • The microbiome, a collection of microorganisms, their genomes, and the surrounding environmental conditions, is akin to a human organ, and knowledge is emerging on its role in human health and diseases. The influence of the microbiome in drug response has only been investigated in detail for the last 10 years. The human microbiome is a complex and highly dynamic system, which varies dramatically …
  • Cooperative DNA binding by proteins through DNA shape complementarity. [Journal Article]
    Nucleic Acids Res 2019; 47(16):8874-8887Hancock SP, Cascio D, Johnson RC
  • Localized arrays of proteins cooperatively assemble onto chromosomes to control DNA activity in many contexts. Binding cooperativity is often mediated by specific protein-protein interactions, but cooperativity through DNA structure is becoming increasingly recognized as an additional mechanism. During the site-specific DNA recombination reaction that excises phage λ from the chromosome, the bact…
  • Bioprospecting solid binding polypeptides for lithium ion battery cathode materials. [Journal Article]
    Biointerphases 2019; 14(5):051007Barannikova EA, Riley SJ, Allen MA
  • Biotemplating presents a promising approach to improve the performance of inorganic materials via specific control over morphology, crystal structure, and the size of particles during synthesis and assembly. Among other biotemplates, solid binding polypeptides (SBPs) isolated for the material of interest provide high binding affinity and selectivity due to distinct combinations of functional grou…
  • Research Progress of M13 Bacteriophage-Based Biosensors. [Review]
    Nanomaterials (Basel) 2019; 9(10)Moon JS, Choi EJ, … Oh JW
  • Recently, new virus-based sensor systems that operate on M13 bacteriophage infrastructure have attracted considerable attention. These systems can detect a range of chemicals with excellent sensitivity and selectivity. Filaments consistent with M13 bacteriophages can be ordered by highly established forms of self-assembly. This allows M13 bacteriophages to build a homogeneous distribution and inf…
  • Quorum sensing for population-level control of bacteria and potential therapeutic applications. [Review]
    Cell Mol Life Sci 2019Wu S, Liu J, … Qiao J
  • Quorum sensing (QS), a microbial cell-to-cell communication process, dynamically regulates a variety of metabolism and physiological activities. In this review, we provide an update on QS applications based on autoinducer molecules including acyl-homoserine lactones (AHLs), auto-inducing peptides (AIPs), autoinducer 2 (AI-2) and indole in population-level control of bacteria, and highlight the po…
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