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(phenotype)
522,527 results
  • Critical Points on the Use of Biologicals in Allergic Diseases and Asthma. [Review]
    Allergy Asthma Immunol Res 2020; 12(1):24-41Agache I, Cojanu C, … Rogozea L
  • Improved understanding of the contribution of immune-inflammatory mechanisms in allergic diseases and asthma has encouraged development of biologicals and small molecules specifically targeting the innate and adaptive immune response. There are several critical points impacting the efficacy of this stratified approach, from the complexity of disease endotypes to the effectiveness in real-world se…
  • Glutamate receptors in domestication and modern human evolution. [Review]
    Neurosci Biobehav Rev 2019O'Rourke T, Boeckx C
  • There has been a recent resurgence of interest in the hypothesis that anatomically modern humans and domesticated species have followed convergent evolutionary paths. Here, we review results from domestication and modern-human evolutionary studies in order to evaluate evidence for shared changes to neurotransmission across these species. We compare genomic and, where available, brain-expression d…
  • Social status and modern-type depression: A review. [Review]
    Brain Behav 2019; :e01464Komori T, Makinodan M, Kishimoto T
  • CONCLUSIONS: On the basis of these findings, we propose that physical interventions such as voluntary exercise, diet, transcranial direct current stimulation, and psychotherapy, rather than psychotropic drugs, may be useful therapeutic approaches for modern type depression, which is a typical example of social status conflict and a phenotype of adjustment disorder to the traditional hierarchical social order.
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