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21,514 results
  • Phosphatidylserine is critical for vesicle fission during clathrin-mediated endocytosis. [Journal Article]
    J Neurochem 2019Varga K, Jiang Z, Gong LW
  • Phosphatidylserine (PS), a negatively charged phospholipid present predominantly at the inner leaflet of the plasma membrane, has been widely implicated in many cellular processes including membrane trafficking. Along this line, PS has been demonstrated to be important for endocytosis, however, the involved mechanisms remain uncertain. By monitoring clathrin-mediated endocytosis (CME) of single v…
  • Composite Pheochromocytoma Presenting as Severe Lactic Acidosis and Back Pain: A Case Report. [Case Reports]
    Indian J Nephrol 2019 Sep-Oct; 29(5):353-356Manoj Kumar RM, Narayanan NK, … Rajagopalan S
  • Pheochromocytoma is a rare, catecholamine secreting tumor arising from chromaffin cells. Presentation of this tumor is highly variable, the most common being hypertension, tachycardia, sweating, and headache. Lactic acidosis and back pain are rare complications of this tumor. We report a 51-year-old gentleman with composite pheochromocytoma, which is rarer than pheochromocytoma, presenting as sev…
  • Therapies targeting the signal pathways of pheochromocytoma and paraganglioma. [Journal Article]
    Onco Targets Ther 2019; 12:7227-7241Liu Y, Liu L, Zhu F
  • Pheochromocytoma and paraganglioma (PCC/PGL) are rare tumors that originate from adrenal or extra-adrenal chromaffin cells. A significant clinical manifestation of PCC/PGL is that the tumors release a large number of catecholamines continuously or intermittently, causing persistent or paroxysmal hypertension and multiple organ functions and metabolic disorders. Though majority of the tumors are n…
  • In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties. [Journal Article]
    Nat Commun 2019; 10(1):3904Kreutzberger AJB, Kiessling V, … Tamm LK
  • Regulated exocytosis of synaptic vesicles is substantially faster than of endocrine dense core vesicles despite similar molecular machineries. The reasons for this difference are unknown and could be due to different regulatory proteins, different spatial arrangements, different vesicle sizes, or other factors. To address these questions, we take a reconstitution approach and compare regulated SN…
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