- Treatment of iron overload syndrome: a general review. [Journal Article]Rev Assoc Med Bras (1992) 2019; 65(9):1216-1222RA
- CONCLUSIONS: Different pharmacological and non-pharmacological strategies are available for the treatment of iron overload and must be used according to etiology and patient compliance. Therapeutic phlebotomy is the basis for the treatment of hereditary hemochromatosis. Transfusional overload patients and those who cannot tolerate phlebotomy need iron chelators.Advances in the understanding of iron overload have lead to great advances in therapies and new pharmacological targets. Research has lead to better compliance with the use of oral chelators and less toxic drugs.
- Factors associated with perioperative mortality in children and adolescents operated for tetralogy of Fallot: A sub-Saharan experience. [Journal Article]J Card Surg 2019JC
- CONCLUSIONS: In this series of consecutive patients operated by a variety of humanitarian surgical teams, cardiopulmonary bypass time/aortic cross-clamp time, and pulmonary valve annulus diameter less than three SD were independently associated with perioperative mortality risk. As some of these factors are modifiable, we suggest that they should be considered during patient selection and at the time of surgical intervention.
- Iatrogenic blood loss in extreme preterm infants due to frequent laboratory tests and procedures. [Journal Article]J Matern Fetal Neonatal Med 2019; :1-6JM
- CONCLUSIONS: Extreme preterm infants lose almost one-third of their total blood volume in the first month of life as a result of blood loss due to multiple blood draws for laboratory investigations, and procedures.
- Patterns of phlebotomy blood loss and transfusions in extremely low birth weight infants. [Journal Article]J Perinatol 2019JP
- CONCLUSIONS: This cohort experienced a high number and volume of blood draws. Draw frequency and transfusions decreased over the first 10 weeks of life.
- Reduction in sample rejections at the preanalytical phase - Impact of training in a tertiary care oncology center. [Journal Article]J Lab Physicians 2019 Jul-Sep; 11(3):229-233JL
- CONCLUSIONS: Intervention in the form of targeted training helps reduce errors and improves the quality of results generated and contributes to better clinical outcomes.
- [CME: Polycythemia vera]. [Journal Article]Praxis (Bern 1994) 2019; 108(13):835-842P
- CME: Polycythemia vera Abstract. Polycythemia vera is a myeloprolifere disease which is characterized by proliferation of all three (erythroid, megakaryocytic and granulocytic) cell lines. The causative mutation is in the JAK2-tyrosine kinase gene. The symptoms are related to the increased red blood cells. Common signs are itching (pruritus) and pain in the hands or feet. The most common complica…
CME: Polycythemia vera Abstract. Polycythemia vera is a myeloprolifere disease which is characterized by proliferation of all three (erythroid, megakaryocytic and granulocytic) cell lines. The causative mutation is in the JAK2-tyrosine kinase gene. The symptoms are related to the increased red blood cells. Common signs are itching (pruritus) and pain in the hands or feet. The most common complications are thrombotic events. Risk factors are age over 60 years and a thrombotic event in the patient's history. The treatment consists of phlebotomy combined with acetylsalicylic acid 100 mg a day. The goal of the therapy is the prevention of the common thrombotic events. During the course of the disease, cytoreductive treatment is indicated in most of the patients.
- Clinical Spectrum and Complications of Polycythemia, in Patients presenting at Tertiary Care Centre at Goa. [Journal Article]J Assoc Physicians India 2019; 67(10):20-24JA
- CONCLUSIONS: Our study revealed that patients with polycythemia Vera are more symptomatic and have a higher requirement of phlebotomy and a higher thrombotic tendency (arterial being more common than venous) as compared to the secondary polycythemia owing to a higher hyperviscocity in the former. Leukocytosis and JAK 2 617F positivity were found to be important predictors of thrombotic risk. Hypertension was found to be frequently associated with Vera as well as in secondary causes due to OSA.
- Modification of the CO-rebreathing method to determine hemoglobin mass and blood volume in patients suffering from chronic mountain sickness. [Journal Article]Exp Physiol 2019EP
- What is the central question of this study? Is it necessary to modify the CO-rebreathing method to acquire reliable measurements of hemoglobin mass (Hbmass) in patients with chronic mountain sickness (CMS)? What is the main finding and its importance? The CO-rebreathing method must be modified because of the prolonged CO-mixing time in CMS patients. After adapting the blood sampling method, relia…
What is the central question of this study? Is it necessary to modify the CO-rebreathing method to acquire reliable measurements of hemoglobin mass (Hbmass) in patients with chronic mountain sickness (CMS)? What is the main finding and its importance? The CO-rebreathing method must be modified because of the prolonged CO-mixing time in CMS patients. After adapting the blood sampling method, reliable and valid results were attained. With this modification, it is possible to quantify the extent of polycythemia and to distinguish between a hemoconcentration and an exclusive enhancement of erythrocyte volume.
- Types and Frequencies of Pre-Analytical Errors in the Clinical Laboratory at the University Hospital of Korea. [Journal Article]Clin Lab 2019; 65(9)CL
- CONCLUSIONS: Clinical laboratory should make efforts to reduce pre-analytical errors in order to report accurate and expeditious results. Reduction of these errors can be achieved through analyzing and correcting the reasons for them and education and training on the phlebotomy teams and, as a result, the credibility of the laboratory may also be enhanced.
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- Reducing Pain and Fear in Children During Venipuncture: A Randomized Controlled Study. [Journal Article]Pain Manag Nurs 2019PM
- CONCLUSIONS: Balloon inflation, ball squeezing, and coughing were all effective in reducing pain and fear associated with venipuncture in children aged 7-12 years. These are simple, rapid, and cost-effective methods that nurses can implement during venipuncture with minimal equipment and preparation.