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1,931 results
  • Novel Viruses in Mosquitoes from Brazilian Pantanal. [Journal Article]
    Viruses 2019; 11(10)Maia LMS, Pinto AZL, … Slhessarenko RD
  • Viruses are ubiquitous and diverse microorganisms arising as a result of interactions within their vertebrate and invertebrate hosts. Here we report the presence of different viruses in the salivary glands of 1657 mosquitoes classified over 28 culicinae species from the North region of the Brazilian Pantanal wetland through metagenomics, viral isolation, and RT-PCR. In total, 12 viruses were foun…
  • Structure and function of the Toscana virus cap-snatching endonuclease. [Journal Article]
    Nucleic Acids Res 2019Jones R, Lessoued S, … Reguera J
  • Toscana virus (TOSV) is an arthropod-borne human pathogen responsible for seasonal outbreaks of fever and meningoencephalitis in the Mediterranean basin. TOSV is a segmented negative-strand RNA virus (sNSV) that belongs to the genus phlebovirus (family Phenuiviridae, order Bunyavirales), encompassing other important human pathogens such as Rift Valley fever virus (RVFV). Here, we carried out a st…
  • NSs Filament Formation Is Important but Not Sufficient for RVFV Virulence In Vivo. [Journal Article]
    Viruses 2019; 11(9)Li S, Zhu X, … Peng K
  • Rift Valley fever virus (RVFV) is a mosquito-borne phlebovirus that represents as a serious health threat to both domestic animals and humans. The viral protein NSs is the key virulence factor of RVFV, and has been proposed that NSs nuclear filament formation is critical for its virulence. However, the detailed mechanisms are currently unclear. Here, we generated a T7 RNA polymerase-driven RVFV r…
  • Circulation of Toscana Virus in a Sample Population of Corsica, France. [Journal Article]
    Viruses 2019; 11(9)Masse S, Ayhan N, … Falchi A
  • Sandfly-borne phleboviruses pathogenic to humans, such as Toscana virus (TOSV) and Sandfly Fever Sicilian virus (SFSV), are endemic in the Mediterranean region. In France, several autochthonous cases of TOSV infection have been described, causing either meningitis or encephalitis. The aim of the present study was to investigate the seroprevalence of TOSV and SFSV antibodies in a healthy populatio…
  • Candidate vaccines for human Rift Valley fever. [Journal Article]
    Expert Opin Biol Ther 2019Ikegami T
  • Introduction. Rift Valley fever (RVF) outbreaks can cause devastating economic loss and public health concerns. RVF virus (RVFV: genus Phlebovirus family Phenuiviridae) is transmitted by mosquitoes, causes abortion in sheep, cattle, and goats, and severe diseases in humans including hemorrhagic fever, encephalitis, or retinitis. RVFV has spread from sub-Saharan Africa into Madagascar, Egypt, Sau…
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