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3,162 results
  • [Impact of mydriatic eyedrops on distance visual acuity in patients with exudative age-related macular degeneration]. [Journal Article]
  • JFJ Fr Ophtalmol 2019 Jun 13
  • Haution D, Lala E, … Pisella PJ
  • CONCLUSIONS: The absence of a clinically significant loss in post-dilation distance VA for exudative AMD could be explained by negligible glare coming from the ETDRS chart, milder photophobia, low pre-dilation VA's and a balance between higher order optical aberrations and diffraction. The opposite result for near VA could essentially be explained by greater glare induced by the light illuminating the Parinaud chart.Our primary goal was not achieved. A study presuming the absence of a clinically significant decrease in post-dilation distance VA would be necessary to consider directly measuring post-dilation VA in eyes with exudative AMD in our daily practice.
  • Clinical and Molecular Characterization of PROM1-Related Retinal Degeneration. [Journal Article]
  • JNJAMA Netw Open 2019 Jun 05; 2(6):e195752
  • Cehajic-Kapetanovic J, Birtel J, … MacLaren RE
  • CONCLUSIONS: In this case-series study, PROM1 recessive variants were associated with early-onset, severe panretinal degeneration. The similar phenotypes observed in patients with homozygous missense variants and splice site variants compared with similarly aged patients with truncating variants suggests that all recessive variants have a null (or loss of function close to null) outcome on PROM1 function. In contrast, the dominant missense cases were associated with a milder, cone-driven phenotype, suggesting that the dominant disease is preferentially associated with cones. This has implications for the development of treatments for this severely blinding disease, and adeno-associated viral vector-based gene therapy and optogenetics could become successful treatment options.
  • GeneReviews®: Alström Syndrome [BOOK]
  • BOOKUniversity of Washington, Seattle: Seattle (WA)
  • Adam MP, Ardinger HH, … Amemiya APaisey RB, Steeds R, … Gunay-Aygun M
  • Alström syndrome is characterized by cone-rod dystrophy, obesity, progressive bilateral sensorineural hearing impairment, acute infantile-onset cardiomyopathy and/or adolescent- or adult-onset restri…
  • Aflibercept-Related Sterile Intraocular Inflammation Outcomes. [Journal Article]
  • OROphthalmol Retina 2019 Apr 11
  • Greenberg JP, Belin P, … Aflibercept Sterile Inflammation Research Group
  • CONCLUSIONS: This is the largest study of aflibercept-related sterile intraocular inflammation, and is the only large report to exclude eyes injected with intraocular antibiotics. Most patients presented early with decreased VA and intraocular inflammation, but without injection, hypopyon, fibrin, or severe pain. Final VA remained decreased in a significant minority of patients.
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