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11,950,068 results
  • Novel insights into the role of urotensin II in cardiovascular disease. [Review]
    Drug Discov Today 2019Pereira-Castro J, Brás-Silva C, Fontes-Sousa AP
  • Urotensin II (UII) is a vasoactive peptide that interacts with a specific receptor called the UT receptor. UII has been implicated in cardiovascular regulation, with promising therapeutic applications based on UT receptor antagonism. The endogenous ligands of the UT receptor: UII and urotensin-related peptide (URP), differentially bind and activate this receptor. Also, the receptor localization i…
  • Proteomic analysis of synovial fluid identifies periostin as a biomarker for anterior cruciate ligament injury. [Journal Article]
    Osteoarthritis Cartilage 2019Brophy RH, Cai L, … Rai MF
  • CONCLUSIONS: Elevated POSTN may provide a synovial fluid biomarker of subacute ACL injury setting separate from OA. Increased expression of POSTN in ACL suggests that the injured ACL may play a pivotal role in POSTN production, which is sensitive to time-from-injury. Previous studies have shown potential catabolic effects of POSTN, raising the possibility that POSTN contributes to the initiation of joint degeneration and may offer a window-of-opportunity to intervene in the early stages of post-traumatic OA.
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