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322,135 results
  • Metabolic effects of skeletal muscle-specific deletion of beta-arrestin-1 and -2 in mice. [Journal Article]
    PLoS Genet 2019; 15(10):e1008424Meister J, Bone DBJ, … Wess J
  • Type 2 diabetes (T2D) has become a major health problem worldwide. Skeletal muscle (SKM) is the key tissue for whole-body glucose disposal and utilization. New drugs aimed at improving insulin sensitivity of SKM would greatly expand available therapeutic options. β-arrestin-1 and -2 (Barr1 and Barr2, respectively) are two intracellular proteins best known for their ability to mediate the desensit…
  • Chronic effects of high intensity interval training on postprandial lipaemia in healthy males. [Journal Article]
    J Appl Physiol (1985) 2019Wilhelmsen AJ, Mallinson J, … Tsintzas K
  • The aim of this study was to determine thechronic (≥72h post-exercise) effects of high intensity interval training (HIIT) on postprandial lipaemia and metabolic markers in healthy volunteers. Eight physically active young males (Mean ± SD: age 22 ± 3years, height 1.77 ± 0.07m, body mass 67.7 ± 6.2kg) underwent two 6h mixed-meal tolerance tests and resting vastus lateralis muscle biopsies, before …
  • Vascularized and Innervated Skeletal Muscle Tissue Engineering. [Review]
    Adv Healthc Mater 2019; :e1900626Gilbert-Honick J, Grayson W
  • Volumetric muscle loss (VML) is a devastating loss of muscle tissue that overwhelms the native regenerative properties of skeletal muscle and results in lifelong functional deficits. There are currently no treatments for VML that fully recover the lost muscle tissue and function. Tissue engineering presents a promising solution for VML treatment and significant research has been performed using t…
  • Reliability of Protein Abundance and Synthesis Measurements in Human Skeletal Muscle. [Journal Article]
    Proteomics 2019; :e1900194Srisawat K, Hesketh K, … Burniston JG
  • We investigated the repeatability of dynamic proteome profiling (DPP), which is a novel technique for measuring the relative abundance (ABD) and fractional synthesis rate (FSR) of proteins in humans. LC-MS analysis was performed on muscle samples taken from male participants (n = 4) that consumed 4 × 50 ml doses of deuterium oxide (2 H2 O) per day for 14 d. ABD was measured by label-free quantita…
  • Coenzyme Q10 supplementation acts as antioxidant on dystrophic muscle cells. [Journal Article]
    Cell Stress Chaperones 2019Mizobuti DS, Fogaça AR, … Minatel E
  • Increased oxidative stress is a frequent feature in Duchenne muscular dystrophy (DMD). High reactive oxygen species (ROS) levels, associated with altered enzyme antioxidant activity, have been reported in dystrophic patients and mdx mice, an experimental model of DMD. In this study, we investigated the effects of coenzyme Q10 (CoQ10) on oxidative stress marker levels and calcium concentration in …
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