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12,961 results
  • Pest risk assessment of Diaporthe vaccinii for the EU territory. [Journal Article]
    EFSA J. 2017 Sep; 15(9):e04924.EFSA Panel on Plant Health (PLH), Jeger M, … Van Bruggen A
  • As requested by the European Commission, the EFSA Panel on Plant Health (PLH) Panel assessed the risk of Diaporthe vaccinii in the EU, focusing on entry, establishment, spread and impacts on cultivated and wild Vaccinium species, the principal hosts being American and European cranberry and blueberry. Several outbreaks occurred in the EU since 1956, but most were eradicated except in Latvia. The …
  • Spatiotemporally tracking of nano-biofilaments inside the nuclear pore complex core. [Journal Article]
    Biomaterials. 2020 Jun 23; 256:120198.Mohamed MS, Hazawa M, … Wong RW
  • Nuclear pore complex (NPC) is a gating nanomachine with a central selective barrier composed mainly of Nups, which contain intrinsically disordered (non-structured) regions (IDRs) with phenylalanine-glycine (FG) motifs (FG-NUPs). The NPC central FG network dynamics is poorly understood, as FG-NUPs liquid-liquid phase separation (LLPS) have evaded structural characterization. Moreover, the working…
  • Tripal and Galaxy: supporting reproducible scientific workflows for community biological databases. [Journal Article]
    Database (Oxford). 2020 Jan 01; 2020Spoor S, Wytko C, … Ficklin SP
  • Online biological databases housing genomics, genetic and breeding data can be constructed using the Tripal toolkit. Tripal is an open-source, internationally developed framework that implements FAIR data principles and is meant to ease the burden of constructing such websites for research communities. Use of a common, open framework improves the sustainability and manageability of such as site. …
  • miR-1184 regulates the proliferation and apoptosis of colon cancer cells via targeting CSNK2A1. [Journal Article]
    Mol Cell Probes. 2020 Jun 30 [Online ahead of print]Chen S, Wang Y, … Zhang X
  • MicroRNA (miRNA) exerts an important part in colon cancer cell proliferation and apoptosis. Meanwhile, the dysregulation of some miRNAs is detected in colon cancer cells. However, it remains unclear about the underlying mechanism of their effects on tumor pathogenesis. The current work aimed to examine the miR-1184 effect on colon cancer cells. The differentially expressed miRNAs (DEMs), includin…
  • Allelopathic and intraspecific growth competition effects establishment of direct sown Miscanthus. [Journal Article]
    Glob Change Biol Bioenergy. 2020 Jun; 12(6):396-409.Awty-Carroll D, Hauck B, … Robson P
  • High yielding perennial crops are being developed as a sustainable feedstock for renewable energy and bioproducts. Miscanthus is a leading biomass crop, but most plantations comprise a sterile hybrid Miscanthus × giganteus that is clonally propagated. To develop new varieties across large areas, rhizome cloning is inefficient, time consuming and expensive. Alternative approaches use seed, and in …
  • A novel missense variant in the RASGRP2 gene in patients with moderate to severe bleeding disorder. [Journal Article]
    Platelets. 2020 Jul 03; 31(5):646-651.Alharby E, Bakhsh MA, … Basit S
  • Inherited platelet function disorder-18 (IPD-18) is a relatively new non-syndromic autosomal recessive bleeding disorder. It is characterized by deficient or dysfunctional CalDAG-GEFI protein. The distinctive feature of the disease is impaired platelet aggregation in response to multiple physiologic agonists. We here report a family with a platelet-type bleeding disorder and a novel mutation in t…
  • Coibamide A targets Sec61 to prevent biogenesis of secretory and membrane proteins. [Journal Article]
    ACS Chem Biol. 2020 Jul 01 [Online ahead of print]Tranter D, Paatero AO, … Paavilainen VO
  • Coibamide A (CbA) is a marine natural product with potent antiproliferative activity against human cancer cells and a unique selectivity profile. Despite promising antitumor activity, the mechanism of cytotoxicity and specific cellular target of CbA remain unknown. Here, we develop an optimized synthetic CbA photoaffinity probe (photo-CbA) and use it to demonstrate that CbA directly targets the S…
  • Design of Split Proximity Circuit as a Plug-and-Play Translator for Point Mutation Discrimination. [Journal Article]
    Anal Chem. 2020 Jul 01 [Online ahead of print]Ang YS, Lai PS, Yung LL
  • Point mutations are the a common form of genetic variation and have been identified as important disease biomarkers. Conventional methods for analyzing point mutations, e.g. PCR, are based on differences in thermal stability of the DNA duplex, which require extensive optimization of the reaction condition and non-trivial design of sequence-selective primers. This motivated the design of molecular…
  • Automated Nerve Fibres Identification and Morphometry Analysis with Neural Network Based Tool in MATLAB. [Journal Article]
    Stud Health Technol Inform. 2020 Jun 26; 272:203-204.Kopka M, Paskal W, … Wlodarski PK
  • Analyses of nerve histology are core assays in basic and applied research and even in clinical setting. Detailed report on nerve morphology may unbiased indicate the current state of a peripheral nerve. Manual method requires trained technician and is a time-consuming procedure. Available plug-ins to well known image processors are limited in use and data outcomes. Thus, the aim of the study was …
  • Calcific Plug Obstructing the Thoracic Aorta. [Journal Article]
    Aorta (Stamford). 2020 Feb; 8(1):23-24.Del Re F, De Martino A, … Bortolotti U
  • We describe a case of a 57-year-old woman with occlusion of the thoracic aorta due to a calcific plug as an unusual cause of refractory hypertension. Middle aortic syndrome, also known as "coral reef aorta," defined as a clinical condition caused by thoracic and/or abdominal aortic stenosis, requires peculiar treatment strategies representing a complex surgical challenge.
  • Cytosolic delivery of proteins by cholesterol tagging. [Journal Article]
    Sci Adv. 2020 Jun; 6(25):eabb0310.Tai W, Zhao P, Gao X
  • Protein-based imaging agents and therapeutics are superior in structural and functional diversity compared to small molecules and are much easier to design or screen. Antibodies or antibody fragments can be easily raised against virtually any target. Despite these fundamental advantages, the power and impact of protein-based agents are substantially undermined, only acting on a limited number of …
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