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51,185 results
  • Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state. [Journal Article]
    PLoS Biol. 2020 Jul 09; 18(7):e3000755.Bu W, Levitskaya Z, … Gao YG
  • Kindlin-1, -2, and -3 directly bind integrin β cytoplasmic tails to regulate integrin activation and signaling. Despite their functional significance and links to several diseases, structural information on full-length kindlin proteins remains unknown. Here, we report the crystal structure of human full-length kindlin-3, which reveals a novel homotrimer state. Unlike kindlin-3 monomer, which is t…
  • Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei. [Journal Article]
    PLoS Negl Trop Dis. 2020 Jul 09; 14(7):e0008458.Quintana JF, Bueren-Calabuig J, … Field MC
  • Defining mode of action is vital for both developing new drugs and predicting potential resistance mechanisms. Sensitivity of African trypanosomes to pentamidine and melarsoprol is predominantly mediated by aquaglyceroporin 2 (TbAQP2), a channel associated with water/glycerol transport. TbAQP2 is expressed at the flagellar pocket membrane and chimerisation with TbAQP3 renders parasites resistant …
  • Potential of NO donor furoxan as SARS-CoV-2 main protease (Mpro) inhibitors: in silico analysis. [Journal Article]
    J Biomol Struct Dyn. 2020 Jul 08 [Online ahead of print]Al-Sehemi AG, Pannipara M, … Tamboli Y
  • The sharp spurt in positive cases of novel coronavirus-19 (SARS-CoV-2) worldwide has created a big threat to human. In view to expedite new drug leads for COVID-19, Main Proteases (Mpro) of novel Coronavirus (SARS-CoV-2) has emerged as a crucial target for this virus. Nitric oxide (NO) inhibits the replication cycle of SARS-CoV. Inhalation of nitric oxide is used in the treatment of severe acute …
  • Antiangiogenic effects of AG36, a triterpenoid saponin from Ardisia gigantifolia stapf. [Journal Article]
    J Nat Med. 2020 Jul 08 [Online ahead of print]Mu LH, Wang LH, … Yan C
  • AG36 is a triterpenoid saponin from Ardisia gigantifolia stapf. Our recent studies proved that AG36 displayed prominent cytotoxicity against breast cancer cells both in vitro and in vivo. However, whether AG36 has antiangiogenic properties is unknown. Therefore, in the present study, we evaluated the antiangiogenic effect of AG36 and the underlying mechanism. The results indicated that AG36 could…
  • Unintended effects of Janani Suraksha Yojana on maternal care in India. [Journal Article]
    SSM Popul Health. 2020 Aug; 11:100619.Sen S, Chatterjee S, … Mohanty SK
  • The Janani Suraksha Yojana (JSY) is the largest ever conditional cash transfer programme worldwide. It primarily aimed to reduce the maternal and child mortality by increasing the facility based delivery in India. Besides, the JSY has resulted in reduction of out-of-pocket expenditure for delivery care and increased antenatal care. Though studies have examined the direct outcome of JSY, limited s…
  • Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years. [Review]
    Acta Pharm Sin B. 2020 Jun; 10(6):961-978.Zhuang C, Pannecouque C, … Chen F
  • Human immunodeficiency virus (HIV) is the primary infectious agent of acquired immunodeficiency syndrome (AIDS), and non-nucleoside reverse transcriptase inhibitors (NNRTIs) are the cornerstone of HIV treatment. In the last 20 years, our medicinal chemistry group has made great strides in developing several distinct novel NNRTIs, including 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT),…
  • Irritant-evoked activation and calcium modulation of the TRPA1 receptor. [Journal Article]
    Nature. 2020 Jul 08 [Online ahead of print]Zhao J, Lin King JV, … Julius D
  • The transient receptor potential ion channel TRPA1 is expressed by primary afferent nerve fibres, in which it functions as a low-threshold sensor for structurally diverse electrophilic irritants, including small volatile environmental toxicants and endogenous algogenic lipids1. TRPA1 is also a 'receptor-operated' channel whose activation downstream of metabotropic receptors elicits inflammatory p…
  • Antidepressant Augmentation: A Review of the Literature and a Review of the Pharmacoeconomic Considerations. [Journal Article]
    J Clin Psychopharmacol. 2020 Jul/Aug; 40(4):396-400.Catalano G, Robeel RA, … Sanchez DL
  • CONCLUSIONS: These findings suggest that among augmentation agents, there are differences in cost that may be highly important in clinical decision making. Other issues of medication monitoring may incur additional costs, and brand name medications offer significantly greater complexity and potential out-of-pocket costs to patients. The use of lithium as a first-line agent for TRD should be considered based on low cost, lowest NNT, and data in support of its efficacy.
  • Drugging "Undruggable" Genes for Cancer Treatment: Are we Making Progress? [Review]
    Int J Cancer. 2020 Jul 07 [Online ahead of print]Duffy MJ, Crown J
  • RAS, TP53 (p53) and MYC are amongst the most frequently altered driver genes in cancer. Thus, RAS is the most frequently mutated oncogene, MYC the most frequently amplified gene and TP53 the most frequently mutated tumour suppressor gene and overall the most frequently mutated gene in cancer. Theoretically, therefore, these genes are highly attractive targets for cancer treatment. However, as the…
  • Use of Platelet-Rich Fibrin in the Treatment of Grade 2 Furcation Defects: Systematic Review and Meta-Analysis. [Review]
    J Clin Med. 2020 Jul 03; 9(7)Tarallo F, Mancini L, … Marchetti E
  • In periodontitis patients, furcation defects are crucial sites to regenerate due to their complex anatomy. Various modern surgical techniques and use of biomaterials have been suggested in the literature. Among all, platelet-rich fibrin (PRF) has potential in tissue regeneration thanks to its role in the release of growth factors. Therefore, the purpose of this study was to evaluate the beneficia…
  • Analysis of medical expenses of inpatients with diabetes: China's Eastern, Central, and Western regions (2013-2015). [Journal Article]
    Public Health. 2020 Jul 04; 185:167-173.Zhang X, Yang S, Zhang X
  • CONCLUSIONS: Inpatients with diabetes in different regions exhibited significant differences in total medical expenses, medical insurance fund payments, and OOP expenses. China should invest more in chronic disease treatment in its central and western regions, narrow the regional differences in medical expenses, and endeavor to ensure equity in the availability and cost of medical services. Moreover, patients with diabetes must be encouraged to access primary care to reduce their medical expenses.
  • The Role of Electrostatics in the Mechanism of Cardiac Thin Filament Based Sensitizers. [Journal Article]
    ACS Chem Biol. 2020 Jul 07 [Online ahead of print]Cai F, Robertson IM, … Sykes BD
  • Heart muscle contraction is regulated by Ca2+ binding to cardiac troponin C. This induces troponin I (cTnI) switch region binding to the regulatory domain of troponin C (cNTnC), pulling the cTnI inhibitory region off actin, and triggering muscle contraction. Small molecules targeting this cNTnC-cTnI interface have potential in the treatment of heart disease. Most of these have an aromatic core wh…
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