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4,920 results
  • [Opioid therapy in patients with liver cirrhosis]. [Journal Article]
    Ther Umsch. 2020; 77(1):14-19.Krähenbühl S
  • Opioid therapy in patients with liver cirrhosis Abstract. There are currently no endogenous markers representing the metabolic activity and the extent of portacaval shunts in patients with liver cirrhosis. The pharmacokinetic properties of the applied drugs must therefore be taken into account when adjusting the dose in patients with liver cirrhosis. For drugs with a high degradation during the f…
  • Hyperprogressive Disease in an Advanced Stage Colon Cancer Patient on Pembrolizumab: A Case Report. [Case Reports]
    Cureus. 2020 Apr 21; 12(4):e7764.Chan KH, Lakkasani S, … Shaaban HS
  • The emergence of immune checkpoint inhibitors (ICIs) in recent years has transformed the landscape of the management of solid tumors. The advancement of immunotherapy has resulted in a brand new set of adverse outcomes not previously seen in classical chemotherapy. One such adverse effect has been termed as hyperprogressive disease (HPD), a phenomenon characterized by rapid tumor progression, whi…
  • Primary hepatic follicular dendritic cell sarcoma: A case report. [Case Reports]
    World J Clin Cases. 2019 Mar 26; 7(6):785-791.Chen HM, Shen YL, Liu M
  • CONCLUSIONS: This case highlights the importance of making suitable chemotherapy regimens for the rare tumor. The combination of gemcitabine, docetaxel, and consolidated radiotherapy may offer a new promising option for the treatment of metastatic hepatic FDCS in the future.
  • Pediatric Budd-Chiari Syndrome: A Case Series. [Journal Article]
    Indian Pediatr. 2018 Oct 15; 55(10):871-873.Redkar R, Bangar A, … Swathi C
  • CONCLUSIONS: The balloon angioplasty has satisfactory outcome in the treatment of acute Budd-Chiari syndrome. In failed cases, the surgical therapy may be attempted, but the outcomes do not appear rewarding.
  • Pathogenesis of Hepatic Encephalopathy in Chronic Liver Disease. [Review]
    J Clin Exp Hepatol. 2018 Sep; 8(3):262-271.Ochoa-Sanchez R, Rose CF
  • Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome that occurs during chronic liver disease (CLD). While ammonia and other precipitating factors in liver disease including inflammation, bile acids, oxidative stress, and lactate play a role in the pathogenesis of HE, the exact mechanism that leads to HE is not fully understood. Notably, accumulating evidence points toward a synergi…
  • Allograft Portacaval Shunt in Small-for-Size Liver in Deceased Donor Liver Transplant. [Case Reports]
    Transplant Proc. 2018 Apr; 50(3):930-932.Nguyen JH, Harnois DM
  • Portal hyperperfusion is detrimental to small-for-size livers (SFSLs) in liver transplantation. Surgical techniques modulating portal inflow provide the most effective approach to protect the SFSL. In this report, we describe a technique creating an allograft portacaval shunt that effectively attenuates portal inflow without a requirement of extensive surgical dissection in the recipient during t…
  • Mesocaval Shunt Creation for Jejunal Variceal Bleeding with Chronic Portal Vein Thrombosis. [Case Reports]
    Yonsei Med J. 2018 Jan; 59(1):162-166.Yoon JK, Kim MD, … Han SJ
  • The creation of transjugular intrahepatic portosystemic shunt (TIPS) is a widely performed technique to relieve portal hypertension, and to manage recurrent variceal bleeding and refractory ascites in patients where medical and/or endoscopic treatments have failed. However, portosystemic shunt creation can be challenging in the presence of chronic portal vein occlusion. In this case report, we de…
  • Portacaval shunting causes differential mitochondrial superoxide production in brain regions. [Journal Article]
    Free Radic Biol Med. 2017 12; 113:109-118.Kosenko EA, Tikhonova LA, … Kaminsky YG
  • The portacaval shunting (PCS) prevents portal hypertension and recurrent bleeding of esophageal varices. On the other hand, it can induce chronic hyperammonemia and is considered to be the best model of mild hepatic encephalopathy (HE). Pathogenic mechanisms of HE and dysfunction of the brain in hyperammonemia are not fully elucidated, but it was originally suggested that the pathogenetic defect …
  • Novel H-shunt Venovenous Bypass for Liver Transplantation in Cynomolgus Macaques. [Journal Article]
    Comp Med. 2017 Oct 01; 67(5):436-441.Kato Y, Griesemer AD, … Kato T
  • Cynomolgus monkeys are often used in preclinical transplantation research. Performing liver transplantation in cynomolgus monkeys is challenging because they poorly tolerate portal vein clamping during the anhepatic phase. Finding an alternative to portal vein clamping is necessary before preclinical liver transplant models can be performed with reliable outcomes. We used 3 different techniques t…
  • Left renal vein ligation for large splenorenal shunt during liver transplantation. [Review]
    ANZ J Surg. 2017 Oct; 87(10):767-772.Tang R, Han D, … Dong J
  • Adequate hepatopetal portal vein blood flow is obligatory to ensure proper liver function after liver transplantation. Large collateral veins as shunts impair portal vein flow and even cause hepatofugal blood flow and portal steal syndrome. In particular, splenorenal shunts in liver transplant recipients can lead to allograft dysfunction and possible allograft loss or hepatic encephalopathy. Rest…
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